<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13476

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMMSNYGNIMDSPKSSPHGGGRSPVVARQDSSGTLKTTISLGKTPTIIHTGPFYSMKEPPAKAELTGDKDLMTEYGLHHTLTKFKEKKFKESLASFLQNIPGINDLITHPVENSTLRSVIEKPPIGGKELLPLTPVQLAGFRLHPGPLPEQYRTTYVTPARKHKNKHKKHKHKDGVTTGQESTLLDSAGLETYEKKHKKQKRHEDDKERKKRKKEKKRKKKNQSPEPGVGLLPGGAGLGGAVGVMGATNLGSLGGGPGPGMSNLGASMGPGVVGGMNSFSSSMQMQQQHQQQMPMQQQQMSSGGLLGSVLGTSGGPGSGVSGGGGGGVGSGGGGGSLLMSQF
Length341
PositionHead
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.699
Instability index58.27
Isoelectric point9.93
Molecular weight35875.53
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13476
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.01|      17|      20|     300|     317|       1
---------------------------------------------------------------------------
  245-  258 (28.30/ 9.43)	GATN.LGS.LG..GGPGP
  300-  317 (29.53/13.90)	SSGGlLGSVLGTSGGPGS
  320-  335 (31.18/11.18)	SGGG..GGGVGSGGGGGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      62.74|      12|      20|     193|     204|       2
---------------------------------------------------------------------------
  163-  173 (20.76/13.23)	KNKHKKHK.HKD
  193-  204 (22.65/15.11)	EKKHKKQKRHED
  214-  225 (19.33/11.81)	EKKRKKKNQSPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.25|      23|      23|      94|     116|       3
---------------------------------------------------------------------------
   63-   81 (25.22/14.12)	....ELT.GDKDLM.TEYGLHHTLT
   94-  116 (39.21/26.29)	SFLQNIP.GINDLI.THPVENSTLR
  117-  141 (27.81/16.37)	SVIEKPPiGGKELLpLTPVQLAGFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.54|      16|      29|     229|     244|       4
---------------------------------------------------------------------------
  229-  244 (30.57/12.65)	GLLPGGAGLG.GAVGVM
  259-  275 (26.97/10.39)	GMSNLGASMGpGVVGGM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13476 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PLPEQYRTTYVTPARKHKNKHKKHKHKDGVTTGQESTLLDSAGLETYEKKHKKQKRHEDDKERKKRKKEKKRKKKNQSPEPGVGLLPGGAGLGGAVGVMGATNLGSLGGGPGPGMSNLGASMGPGVVGGMNSFSSSMQMQQQHQQQMPMQQQQMSSGGLLGSVLGTSGGPGSGVSGGGGGGVGSGGGG
2) SNYGNIMDSPKSSPHGGGRSPVVARQDSSGTLKTTISL
146
3
333
40










Molecular Recognition Features






MoRF SequenceStartStop




1) GLLGSVLG
2) SLLMSQF
303
335
310
341