<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13475

Description mediator of RNA polymerase II transcription subunit 14 isoform X3
SequenceMAPTPLPLPLPLEQMPGVGGGGGGYLPAGQEGGPRINTMSMSVLIDFIIQRTYHELTVLAELLPRKTDMERKVEIYDYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPAEKRQTLLRLNQVIQHRLVTGKLLPQMREFRIRNGRVTFEVKHEFSVSLTVMGDNPTVPWRLLDIDVLVEDKETGDGKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNITVEEYVPGVKLTVSYWRDLKSELGYRLTVQSDPSEIGRPLAVVHVPSLGAKESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLSPCLRAEQIHITIDTHTGMFRCHVPKHLDCPITEEMQDCLNGDRGKLPALLSELRFWITHRRCDKTLQHLPATATETLPFLTPPEQELLQPGRHKIYVKLHRHPNIVLVVQLKEKSTMPNEMEYTFHLGFVAFQKDEQDVIDDSAKQLVSVVAQPHSDIPKCYSKLMRLIEFDTFVATHGPGTEVDAEVSPHKRKSNGDLLAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFMNLAQTLSKHNIPHSGLQVEANATSLVLKILALPQPGKTTFVNQQQQQQGPAAGTGENKPSGASGLPKIEPHVWDDLMRRVLSISVRSQTNKNSQVRIWVVEFVFYSTPLQSSHQKEQGSRRTVYLTYEQANHDFSKTVEDLLNDWSKIVYLYTLVYDFAEQLRNKRLSLCDMLVVKSYSYMNLLLGYGPKKEVSCNIYWSVQSHGFRLTFVGGMSAVNAHSMMRDQLAQHLNQQHSLTQIAQILHETYNPMSSIAKLPVLPFLGIPVPVLSFCMLAQSPCLMRLTYQAVYCLELRFRANRLVSIRDGASSRFERNVVEEFTPIQGLKAFLSKYVDESAAYRGRAAHEDDNPLSPMEDAFGGPSSVAGVSAGGSSPFLCTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGAAGGSGAQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHKSTGGGAGGAGGPDRAGSRVTLNRPWAGAVPTLLTHEALETLCRPSPHPNKDINVPDMSPLERFLGCVYMRRQLHRNIQSEETLTALNSTEPGVVLFKVDGLQCQVVLNQMHMQTLHLKISQLPPMPDKLPPPFQLSQDDLMVIEQYFDTRVAAPPYRPNSLHSICRLLNLPAQVLKDFVQIMRLELKPELGGDQLKWTVQMCMRMPPSAVPIVPIGNACVVLGRMKILFFLQITRIPYGAGMGVPKDWKDSPSLVLPIVYDIQTNVTQMAERTGQVTSPTMTAASTLLRRFAEFNAQQNQCTLFPAITDLLTNLQLATEMPQPPPNQSIGPPVGVGVGVGVGVGSSPNPMMPMQQLQPQQVGPQGPVGPGVYPQMGPNPGGPQ
Length1557
PositionTail
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.07
Grand average of hydropathy-0.263
Instability index54.97
Isoelectric point8.26
Molecular weight172740.80
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13475
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     138.08|      23|      23|    1101|    1123|       1
---------------------------------------------------------------------------
 1051- 1077 (31.90/ 8.61)	RD.....SGLRFPAPHTP.PSSsnPHTpasPH.P
 1078- 1106 (30.33/ 7.86)	SAgaaggSGAQGHGNFN.LTSPpaPHM...PH.P
 1107- 1129 (37.16/11.10)	SP.....SGLMPSSPLNPQP...sPHM...VHsP
 1520- 1543 (38.70/11.84)	SP.....NPMMPMQQLQPQQVG..PQG...PVgP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.65|      21|      23|    1136|    1156|       2
---------------------------------------------------------------------------
 1136- 1156 (38.39/16.95)	MQSHQDSPFTAMSPA..NNNWPG
 1160- 1178 (35.45/15.03)	MP..RPSPRPGQSPE..HKSTGG
 1179- 1201 (28.80/10.69)	GAGGAGGPDRAGSRVtlNRPWAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.75|      14|      23|     155|     168|       3
---------------------------------------------------------------------------
  155-  168 (26.14/16.94)	TYNRLPTCIRERIV
  181-  194 (23.62/14.58)	TLLRLNQVIQHRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.86|      16|      23|     786|     806|       4
---------------------------------------------------------------------------
  786-  806 (16.58/24.04)	VYLtYEQAnHDFSktvEDLLN
  812-  827 (30.27/17.22)	VYL.YTLV.YDFA...EQLRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.43|      14|      29|     344|     359|       5
---------------------------------------------------------------------------
  344-  359 (19.38/17.43)	VQSDPSEIGRplAVVH
  376-  389 (24.05/13.60)	VRSEHLSMER..LIVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.21|      28|      30|      34|      62|       6
---------------------------------------------------------------------------
   34-   62 (45.00/40.26)	PRINTMSMSVLI.DFiIQRTYHELTVLAEL
   64-   92 (45.21/34.72)	PRKTDMERKVEIyDY.AARTRHLFTRLNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.92|      22|      31|     289|     310|       7
---------------------------------------------------------------------------
  283-  306 (34.91/23.99)	YNCL.......hyFCQSLQLEVLYTQTLR..LN
  307-  339 (28.01/17.63)	YERLddnnitveeYVPGVKLTVSYWRDLKseLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.09|      12|      23|    1016|    1027|       8
---------------------------------------------------------------------------
 1016- 1027 (23.68/13.38)	SP.MEDAFGGPSS
 1037- 1049 (20.41/10.33)	SPfLCTGMRGPQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.28|      22|      23|     475|     497|       9
---------------------------------------------------------------------------
  475-  497 (33.96/23.35)	KLPALLSELRFWITHRRcDKTLQ
  498-  519 (37.32/19.99)	HLPATATETLPFLTPPE.QELLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.37|      21|      31|    1364|    1385|      11
---------------------------------------------------------------------------
 1364- 1385 (36.95/25.74)	LGGDQLKWTVQMcMRMPPSA...VP
 1396- 1419 (33.42/17.50)	LGRMKILFFLQI.TRIPYGAgmgVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.00|      24|      24|    1451|    1474|      12
---------------------------------------------------------------------------
 1451- 1474 (40.94/25.25)	T.SPTMTAASTLLRRFAEF.NAQQNQ
 1476- 1501 (34.07/19.69)	TlFPAITDLLTNLQLATEMpQPPPNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.22|      20|      23|     734|     755|      13
---------------------------------------------------------------------------
  734-  755 (29.49/24.70)	HVWddLMRRVL.SISVRSQTNKN
  759-  779 (30.73/18.33)	RIW..VVEFVFySTPLQSSHQKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.51|      28|      31|    1273|    1303|      14
---------------------------------------------------------------------------
  888-  924 (34.55/16.56)	DQLAQH..LNQ..........QHsltqiAQILHetynpmSSIAKLPVLP
 1273- 1300 (53.50/33.01)	DGLQCQVVLNQ..........MH.....MQTLH......LKISQLPPMP
 1312- 1345 (35.46/20.06)	DDL...MVIEQyfdtrvaappYR.....PNSLH.......SICRLLNLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13475 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGGSSPFLCTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGAAGGSGAQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHKSTGGGAGGAGGPDRAGSRVTLNRPWAGAVP
2) LQLATEMPQPPPNQSIGPPVGVGVGVGVGVGSSPNPMMPMQQLQPQQVGPQGPVGPGVYPQMGPNPGGPQ
1033
1488
1204
1557










Molecular Recognition Features






MoRF SequenceStartStop




NANANA