<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13467

Description mediator of RNA polymerase II transcription subunit 12 isoform X1
SequenceMLSMLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAHNSNVNASKVSAFFSGVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKRAPSFNKKEEIFILLCENQVNMQRATWFIKLSAAYTVSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQEYYQQSHEKSSANGGTAGSLTASGNNSTTNGTSGSSSINSVTASSAPSNVIPVPSMASPLPPIHSPANGQQGAPGGGVGSGSVMPTTGSLGGVVGGPGSSVVGGAAGAGAVVPPGSTISGIGSQFEDSRNALKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQASFDEPLKKLVLSFALQYMHDFVQSERLCRKMAYIVSKKLAQLLITVVEQQAIKELDEHKLQHDPYELALQEQMSCPHHRDIVLYLSTILQIVTIECPTALVWSGIAAHRAPSSLLGSPLDHLPLAPSVLPMPSRCPRTNQEIRRQLRAAESDIVLRTQHAEQRWFAAKWRSAGKNHYTGVLATLDHLDTHCFDRMEHNNSIDTLYAHIFPSPTTSRRREEDQLEPRPAYEPKQDKDTVRILCEWAVSGQRWGEHRAMVVAILLDKRQIDVTSTPADQQSSDKDDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDEHNSSSQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLLESVLVIKSGATATKTSPPPPAPPPTTTHGFDDDGFGGGIDFKHNEFDDSNVDDDLDKLVQNIKEKGQQHEAPDSPKIGPPGDGETTTGGSISRHYVYTKHFPIPQDDPSMSSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSIDVAAAGHVKKHSRNEFNFEATTSKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLELCDSLLKELPEVELQLQSKKSNLVRSYTTSLALYIVSILRRYHSCLLLSPEQTLSVFDGVCRTIRHVSNPSECSSAERCIIAYLSDLHESCVLLQGKEQSTEYYQQLQCINKFKDIFNTPEQLSLPPQGYNPQLLQELFMAPRRGGKLDPHWLGTLKESSANVYSFVSNALIAVCRETDNERLNDVALACAELTASCNVLSEEWIAALQSLCSGSKSPRYPHLGGQVDIGQGKTHNALAVFVCILVARHCFSLADFVSKFALPTLARSVSAGGAELSVDAEAGARLTCHLVLKLFKTLEIPQPGMYSVSTSPNPLHAVGNDFSIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPLAAGSGSSSSGGLGGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSSLTSEPEALQQPSVGGMEQVSLLEFAQAVLKQICAQEHVLERCLKNAEQLCDMIIDEMLTAKQAQRVLHMICYPEAEFKIISELDQRSMIVRILENLGQWTLRISWLDLQLMYRQSLSNNAELNIWLDTVARAAIDVFHMEEVVLPGAVKATHKPKPSTWLVAPLIAKLTPAVQGRILRVAGQVLESMNYFSKVSKSDCNSSGSGDEREKSNSCHSSNSYGLGNVAARNKKMPLNYQPFLGLILTCLKGQDEYKENLLVSLYAQLSQCLQSFAELDTIGGIDEPQAREEILDALQLRFSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSDDERHYMNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHAGMDSKGNKICEMDKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPLPLPPEDIEPVPEKICIKDEMKADTPSSVDQSPSAVVGGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQQQPQLAPQPQQAQNVQQQQMQQQQQQQQQQQQHMQQQQMQPNPMGQMQMNMPMNMQQFAQNPNNMMQPNAMMQQQQHMQQMNNNPLQQQLNVGGGNGQQNPQMNFMQQGPGGGGAGPSGMPGQQQQWHNAQQQQQPPQPYHNQYAPHQQNMQSNRIERPPLNSNSKQALSQMLRQRQPFQQQQAQQGPGGGFNPMQQQPQPSQQQPGPQQQMNPNQMRQQQMNPQQNPQSVAAFNAMQQQQQQNAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMPQNPMMQQQMPQNMVGMVNPNANQMMQAGGAQGGNGVGVGVGVGVGVGGAGNNPNIGMGGMPQQGIMQQQPQQQPQQQVQFQNFQNQYQQQQQQQQQGMQQQGGGGGVGVGVGVGMAPNQQQQQQANMMGNFNPQMQQANRNNPDFMAVAAAAQQQQQQQQQQQRVVPGGMMAGNRNQYMNQAPNVTMSNMMGPGPGGVVGQVPPYARQQPAGGGKPGVLNTQQQFQQQQQQQQQLRHQQMMQMQGMGGGAGGGMGSGPQQPGGAVGGGGGGGMVPQQQSMNQQQTPNLVAQLQRQNMMGQQQQYQPPPY
Length2540
PositionKinase
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.545
Instability index56.40
Isoelectric point7.87
Molecular weight280236.50
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13467
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     138.13|      16|      16|    1953|    1968|       1
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 1949- 1967 (28.85/ 7.55)	QlapQPQQAQN...VQQQQMQQ
 1968- 1986 (28.81/ 7.53)	QqqqQQQQQQH...MQQQQMQP
 2038- 2053 (26.89/ 6.45)	G...GGNGQQN...PQMNFMQQ
 2151- 2169 (26.48/ 6.23)	P...GPQQQMNpnqMRQQQMNP
 2185- 2197 (27.10/ 6.57)	Q......QQQN...AQQQQMNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     644.31|      66|      68|    2262|    2327|       2
---------------------------------------------------------------------------
 1908- 2018 (45.50/10.91)	.......Q........SPSAVVGGTG...RGR................GKGTTtrkrkP...K.....NPKTPPVVN..T.Q....QQQPqlapqpqqaqnvqqqqmqqqqQQqqqqqqhmqqqqmqpNPMGQMQmnmpmnMQ..QFaQNPNNMMQpnamMQ
 2019- 2095 (85.33/27.26)	QQQ..hmQ........QMNNNPLQQQ...LNVgggngqqnpqmnfmqqGPGGG.....G...A.....GP....SGM..P.GQ...QQQW.....................HN...............AQQQQQP......PQ..PY.HNQYAPHQ....QN
 2096- 2134 (40.42/ 8.82)	MQS........................................................nriE.....RP..PLNSN..S.KQALSQMLR.....................QR...............QP...........FQ.....QQQAQQGP....G.
 2202- 2257 (89.11/28.81)	QQQ..fmR........GGN.....MR...PGM................A.PNQ.....M...N.....QMNMGGQGM..P.QNPMMQQQM.......................................PQNMVG......MV..N..PN..ANQM....MQ
 2258- 2324 (128.47/44.98)	AGG...aQ........GGNGVGVGVG...VGV................GVGGA.....G...N.....NPNIGMGGM..P.QQGIMQQQP.....................QQ...............QPQQQVQ......FQ..NF.QNQYQQQQ....QQ
 2325- 2389 (85.89/27.50)	QQQgmqqQ........GGGG...GVG...VGV................GVGMA.....P...NqqqqqQANM.MGNF..N.PQ..MQQAN.....................RN...............NP.D.........FM..AV.AAAAQQQQ....QQ
 2390- 2462 (85.17/27.20)	QQQ....Q.........QRVVPGGMM...AGN................RNQYM.....N...Q.....APNVTMSNMmgPgPGGVVGQVP..................pyaRQ...............QPAGGGK......PGvlNT.QQQFQQQQ....QQ
 2463- 2535 (84.43/26.89)	QQQlrhqQmmqmqgmgGGAGGGMGSGpqqPGG................AVGGG.....G...G.....G...GM..V..P.QQQSMNQQ.......................Q...............TPNLVAQ......LQ..R..QNMMGQQQ....QY
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.76|      21|     477|     260|     280|       3
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  260-  280 (41.54/21.60)	PPIHSPANGQQGAPGGGVGSG
  750-  770 (44.22/23.58)	PPPAPPPTTTHGFDDDGFGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.82|      57|     476|     926|     988|       5
---------------------------------------------------------------------------
  926-  988 (91.61/68.70)	QCAANVLEQ..LNGFALGNNNYLPVQEHV............AFLFDLMELALNIYSLLEL.CdsllkeLPEVELQLQS
 1403- 1474 (82.21/50.45)	QPSVGGMEQvsLLEFAQAVLKQICAQEHVlerclknaeqlcDMIIDEMLTAKQAQRVLHMiC......YPEAEFKIIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     415.51|     140|     154|    1485|    1638|      13
---------------------------------------------------------------------------
 1490- 1638 (224.80/158.76)	GQWTLRISWL.DLQLMYRQSLSNNAELNI..WLD.TVARAAI.DVFHMEEVVLPGAVKATHK.PKPST.WlvAPLIAKLtpAVQGRI.LRVAGQVLES.MNYFSKVSKSdcnSSGSGDEREKSNSCHS.SNSYGLGNVAA.R..NKKMPLNYQPflGLILTC
 1641- 1793 (190.71/105.77)	GQDEYKENLLvSLYAQLSQCLQSFAELDTigGIDePQAREEIlDALQLRFSLVGGMFEAIQKnSTPTTdW..AILLAQL..VCQGVVdLSCNRELFTTvVDMLATLVHS...TLVSDDERHYMNLMKKlKKEIGEKNNASiRviRQLLPLYKQP..TEVIAC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13467 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDLDKLVQNIKEKGQQHEAPDSPKIGPPGDGETTTGGSI
2) GGAGNNPNIGMGGMPQQGIMQQQPQQQPQQQVQFQNFQNQYQQQQQQQQQGMQQQGGGGGVGVGVGVGMAPNQQQQQQANMMGNFNPQMQQANRNNPDFMAVAAAAQQQQQQQQQQQRVVPGGMMAGNRNQYMNQAPNVTMSNMMGPGPGGVVGQVPPYARQQPAGGGKPGVLNTQQQFQQQQQQQQQLRHQQMMQMQGMGGGAGGGMGSGPQQPGGAVGGGGGGGMVPQQQSMNQQQTPNLVAQLQRQNMMGQQQQYQPPPY
3) IEPVPEKICIKDEMKADTPSSVDQSPSAVVGGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQQQPQLAPQPQQAQNVQQQQMQQQQQQQQQQQQHMQQQQMQPNPMGQMQMNMPMNMQQFAQNPNNMMQPNAMMQQQQHMQQMNNNPLQQQLNVGGGNGQQNPQMNFMQQGPGGGGAGPSGMPGQQQQWHNAQQQQQPPQPYHNQYAPHQQNMQSNRIERPPLNSNSKQALSQMLRQRQPFQQQQAQQGPGGGFNPMQQQPQPSQQQPGPQQQMNPNQMRQQQMNPQQNPQSVAAFNAMQQQQQQNAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMPQNPMMQQQMPQNMVGMVNPNANQMMQAGGAQG
4) MLSMLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAH
5) SNVIPVPSMASPLPPIHSPANGQQGAPGGGVGSGSVMPTTGSL
6) YQQSHEKSSANGGTAGSLTASGNNSTTNGTSGSSSINSVTAS
784
2278
1885
1
247
202
823
2540
2263
56
289
243










Molecular Recognition Features






MoRF SequenceStartStop




1) RYILLF
852
857