<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13462

Description mediator of RNA polymerase II transcription subunit 23
SequenceMDMETQVIDTVNEFLKVDSIDEAFVSVIVFKPNGEQERATSFANDLVTAFGNVAQENRDQVLRLYLVRAAGASGYHIKVLMSALVKLVDAHVITARMLCDKVLMCEKLDFEHRTFWIESFRLIKRVIAQVDYKGVREIMKVCRDKAQWFPLNVNVTYMPQLLAVEDILRFIFDRNNCLLPAYFIANEIMRPFPYHWKLNRLMTDFVEEFRTTAQMVSIIGHASMLPIVEHFGYADHMMNSWRLDHNTLKFNFKGSLPYEPELLEEQKPLLRYVLEQPYSREMVSQMLNLQKHQKQRYNALEEQLVNLIVHAMEMTETNDATAGSGFNSSDEQITPYEWVWLHLSSQLIYFVLFQFVSFMHIVLALHEKLSKLELRKGRDQLMWILLQFISGSIQKNPITNFLPVFRLFDLLYPELEPLKLPDINKSSTVRHMAPICVWIHLMKKARVENMNITRPLPIALKNHYDFLQHLVTPNTLMNMTLGNDFRIILICNAYSTNQEYFGRPMGLLVDALNGNSKSPNGAQIPAVTFSVTVLDSLTVHSKMSLIHGFVTQMLKQAQTKGQVPAAALLETYARLLVYTEIESLGIKGFLSQLMPTVFKNHAWAMLHTLMEMFSYRLHHVPTHYRVQLLSLLHSLSSVPQTNKMQLNLCFESTALRLITSIGSAEFQPQFSRYFNEKSPGAVASNESEELNRVLILTLARSMHVHGGGDEMQGWCKDFLSNIMQHTPHSWPMHSLACFPPALNEYFTQNNQPPENKQQLKKAVEEEYRTWTSMTNENDIIAHFLRPTTNPLFLCLLFKIIWETENISPVAYKILEGISARALSTHLRKFCDFLVAEVASSSDGREFIHKCVDTINNMIWKFNVVTIDRVVLCLALRTHEGNEAQVCFLIIQLLMLKASELRNRVQEFCKDNNPDHWKQSNWQDKHLSFHQKYPEKFALDESASQIPLPVYFSNVCLRFLPVLDVVVHRFIELTITNVHQILGFILDHLSVLYKFHDRPITYLYNTLHYYERILRDRPALKKKLVGAITSAFSEIRPPNWSLSEPYKVFLQNQDSLWTPELSYYMSLIRRLADTISGKNVFYSTDWRFNEFPNAPTHALYVTCVELLGLPVAPTVVANNLIDVIVTGYAVIPQKDIHSYINAVGIVLAALPEPYWSGIYDRLQDMLNTPNMLNWTYRFNAFELFNFKTVREAMLEKTYAVVLAVAHSVFHHMGAFKLAAMTRYIKDKLKPCVRTEQQLLYLCHVFGPFLQRIELEKPNAVAGIAVLLYEILEIVDKQHGPKPMQYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRPLLQMRLRFITHLNLEDIHSEKIADNANNNAITGQTQSPMQVQHQQQPQQQQQQQQQQQQQQQQQQQQQHQQQQQMQLQQQQQQQQQQVNAGQTTSVPLGSGGNMQQQQQLNHQQQMYMQHMQQQHQQQMQNMRHN
Length1452
PositionTail
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.10
Grand average of hydropathy-0.204
Instability index41.79
Isoelectric point7.25
Molecular weight168518.75
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13462
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.22|      24|      24|    1359|    1382|       1
---------------------------------------------------------------------------
 1359- 1382 (51.60/26.36)	QHQQQPQQQQQQQQQQQQQQQQQQ
 1383- 1404 (47.80/23.90)	Q..QQHQQQQQMQLQQQQQQQQQQ
 1422- 1445 (49.83/25.22)	QQQQQLNHQQQMYMQHMQQQHQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.92|      16|      16|    1080|    1095|       2
---------------------------------------------------------------------------
 1080- 1095 (32.99/20.61)	FYSTDWRFNEFPNAPT
 1098- 1113 (28.93/17.17)	LYVTCVELLGLPVAPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.26|      52|      75|     777|     830|       3
---------------------------------------------------------------------------
  777-  830 (84.35/90.01)	NDIIAHFLRPTTNPLFLCLLFKIiwETENISPVAYKILE..GISARALSTHLRKFC
  855-  908 (85.91/80.85)	NNMIWKFNVVTIDRVVLCLALRT..HEGNEAQVCFLIIQllMLKASELRNRVQEFC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.28|      26|      99|     149|     174|       4
---------------------------------------------------------------------------
  149-  174 (45.14/28.30)	FPLNVNVTYMPQLLAVED.ILRFIFDR
  250-  276 (40.14/24.32)	FNFKGSLPYEPELLEEQKpLLRYVLEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      13|      16|     612|     627|       5
---------------------------------------------------------------------------
  615-  627 (25.51/22.26)	YRLHHVPTHYRVQ
  633-  645 (22.52/ 8.84)	HSLSSVPQTNKMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.03|      37|      53|     383|     435|       6
---------------------------------------------------------------------------
  383-  420 (61.08/62.82)	WILLqFISGSIQKNPITNFLPVF..RLFDLLYPELEPLKL
  438-  476 (62.95/31.14)	WIHL.MKKARVENMNITRPLPIAlkNHYDFLQHLVTPNTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.17|      57|     608|      41|      99|       7
---------------------------------------------------------------------------
   41-   99 (90.21/83.42)	SFANDLVTAFGNVaqENRDQVLRLYLVRAAGA.....SGYHIKVLMSALVKLVDAHVITARM..LC
  652-  715 (89.97/75.53)	STALRLITSIGSA..EFQPQFSRYFNEKSPGAvasneSEELNRVLILTLARSMHVHGGGDEMqgWC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.14|      23|      25|     961|     985|       8
---------------------------------------------------------------------------
  945-  969 (34.75/19.74)	IPLPVyfSNV..CLRFLPVLDVVVHRF
  970-  994 (33.38/25.50)	IELTI..TNVhqILGFILDHLSVLYKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.68|      14|      24|     202|     215|      11
---------------------------------------------------------------------------
  202-  215 (25.26/17.36)	MTDFVEEFRTTAQM
  224-  237 (27.42/19.54)	MLPIVEHFGYADHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.54|      15|      24|    1255|    1269|      12
---------------------------------------------------------------------------
 1255- 1269 (25.17/17.38)	KP.NAVAGIAVLLYEI
 1280- 1295 (26.37/18.60)	KPmQYMDQICDFLYHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.75|      25|      38|     523|     554|      19
---------------------------------------------------------------------------
  523-  554 (38.46/43.40)	QIPAVTFsvtvldsLTVHSKM.......SL.IHGFVTQML
  562-  594 (31.29/20.16)	QVPAAAL.......LETYARLlvyteieSLgIKGFLSQLM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13462 with Med23 domain of Kingdom Metazoa
Unable to open file!