<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13461

Description mediator of RNA polymerase II transcription subunit 14 isoform X2
SequenceMAPTPLPLPLPLEQMPGVGGGGGGYLPAGQEGGPRINTMSMSVLIDFIIQRTYHELTVLAELLPRKTDMERKVEIYDYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPAEKRQTLLRLNQVIQHRLVTGKLLPQMREFRIRNGRVTFEVKHEFSVSLTVMGDNPTVPWRLLDIDVLVEDKETGDGKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNITVEEYVPGVKLTVSYWRDLKSELGYRLTVQSDPSEIGRPLAVVHVPSLGAKESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLSPCLRAEQIHITIDTHTGMFRCHVPKHLDCPITEEMQDCLNGDRGKLPALLSELRFWITHRRCDKTLQHLPATATETLPFLTPPEQELLQPGRHKIYVKLHRHPNIVLVVQLKEKSTMPNEMEYTFHLGFVAFQKDEQDVIDDSAKQLVSVVAQPHSDIPKCYSKLMRLIEFDTFVATHGPGTEVDEVSPHKRKSNGDLLAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFMNLAQTLSKHNIPHSGLQVEANATSLVLKILALPQPGKTTFVNQQQQQQGPAAGTGENKPSGASGLPKIEPHVWDDLMRRVLSISVRSQTNKNSQVRIWVVEFVFYSTPLQSSHQKEQGSRRTVYLTYEQANHDFSKTVEDLLNDWSKIVYLYTLVYDFAEQLRNKRLSLCDMLVVKSYSYMNLLLGYGPKKEVSCNIYWSVQSHGFRLTFVGGMSAVNAHSMMRDQLAQHLNQQHSLTQIAQILHETYNPMSSIAKLPVLPFLGIPRPQVPVLSFCMLAQSPCLMRLTYQAVYCLELRFRANRLVSIRDGASSRFERNVVEEFTPIQGLKAFLSKYVDESAAYRGRAAHEDDNPLSPMEDAFGGPSSVAGVSAGGSSPFLCTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGAAGGSGAQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHKSTGGGAGGAGGPDRAGSRVTLNRPWAGAVPTLLTHEALETLCRPSPHPNKDINVPDMSPLERFLGCVYMRRQLHRNIQSEETLTALNSTEPGVVLFKVDGLQCQVVLNQMHMQTLHLKISQLPPMPDKLPPPFQLSQDDLMVIEQYFDTRVAAPPYRPNSLHSICRLLNLPAQVLKDFVQIMRLELKPELGGDQLKWTVQMCMRMPPSAVPIVPIGNACVVLGRMKILFFLQITRIPYGAGMGVPKDWKDSPSLVLPIVYDIQTNVTQMAERTGQVTSPTMTAASTLLRRFAEFNAQQNQCTLFPAITDLLTNLQLATEMPQPPPNQSIGPPVGVGVGVGVGVGSSPNPMMPMQQLQPQQVGPQGPVGPGVYPQMGPNPGGPQ
Length1559
PositionTail
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.07
Grand average of hydropathy-0.270
Instability index54.94
Isoelectric point8.34
Molecular weight173051.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13461
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     131.78|      20|      39|    1060|    1079|       1
---------------------------------------------------------------------------
 1035- 1054 (31.73/11.23)	AGGSSP.FLCTG..MRGPQSPRD
 1060- 1079 (44.24/19.00)	PAPHTP.PSSSN..PHTPASPHP
 1101- 1123 (32.01/11.40)	PAPHMPhPSPSGlmPSSPLNPQP
 1545- 1559 (23.80/ 6.30)	P.GVYP.QMGPN..PGGPQ....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.21|      28|      29|      34|      62|       2
---------------------------------------------------------------------------
   34-   62 (45.00/42.37)	PRINTMSMSVLI.DFiIQRTYHELTVLAEL
   64-   92 (45.21/36.54)	PRKTDMERKVEIyDY.AARTRHLFTRLNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.46|      12|      30|    1496|    1507|       3
---------------------------------------------------------------------------
  694-  712 (19.08/ 6.68)	LP..QPgkttfvnQQQQQQGP
 1496- 1507 (27.37/13.39)	MP..QP.......PPNQSIGP
 1527- 1539 (20.02/ 7.45)	MPmqQL.......QP.QQVGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.92|      22|      30|     289|     310|       4
---------------------------------------------------------------------------
  283-  306 (34.91/21.44)	YNCL.......hyFCQSLQLEVLYTQTLR..LN
  307-  339 (28.01/15.69)	YERLddnnitveeYVPGVKLTVSYWRDLKseLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.62|      22|      23|    1130|    1151|       5
---------------------------------------------------------------------------
 1130- 1151 (41.04/21.55)	SPGPNTLYMQSHQDSPFTAMSP
 1156- 1173 (37.50/18.94)	WPGSPS..MP..RPSPRPGQSP
 1185- 1206 (37.07/18.63)	AGGPDRAGSRVTLNRPWAGAVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.37|      21|      31|    1366|    1387|       6
---------------------------------------------------------------------------
 1366- 1387 (36.95/28.75)	LGGDQLKWTVQMcMRMPPSA...VP
 1398- 1421 (33.42/19.54)	LGRMKILFFLQI.TRIPYGAgmgVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.75|      14|      23|     155|     168|       7
---------------------------------------------------------------------------
  155-  168 (26.14/15.87)	TYNRLPTCIRERIV
  181-  194 (23.62/13.65)	TLLRLNQVIQHRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.14|      26|      29|    1283|    1311|       8
---------------------------------------------------------------------------
  925-  944 (26.60/ 6.49)	LGI..........PRPQVPVLSFCMLAQSP......
 1283- 1308 (48.11/20.71)	LNQ..........MHMQTLHLKISQLPPMPDKLPPP
 1319- 1353 (33.42/13.90)	IEQyfdtrvaappYRPNSLH.SICRLLNLPAQVLKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.86|      16|      23|     785|     805|       9
---------------------------------------------------------------------------
  785-  805 (16.58/32.25)	VYLtYEQAnHDFSktvEDLLN
  811-  826 (30.27/23.20)	VYL.YTLV.YDFA...EQLRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.16|      22|      32|     456|     479|      13
---------------------------------------------------------------------------
  456-  479 (37.18/25.63)	HLDCPITeeMQDCLNGDRGKLPAL
  489-  510 (39.98/21.85)	HRRCDKT..LQHLPATATETLPFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.22|      20|      23|     733|     754|      16
---------------------------------------------------------------------------
  733-  754 (29.49/25.07)	HVWddLMRRVL.SISVRSQTNKN
  758-  778 (30.73/18.62)	RIW..VVEFVFySTPLQSSHQKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.34|      17|     359|     872|     900|      17
---------------------------------------------------------------------------
  884-  900 (31.01/19.59)	MMRDQLAQHLNQQHSLT
 1244- 1260 (30.33/16.05)	YMRRQLHRNIQSEETLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.48|      23|      32|     971|     994|      18
---------------------------------------------------------------------------
  971-  994 (34.77/32.31)	DGASSRfERNVVEEFTPIQGLK.AF
 1001- 1024 (36.71/27.50)	ESAAYR.GRAAHEDDNPLSPMEdAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.26|      15|      23|    1451|    1465|      19
---------------------------------------------------------------------------
 1451- 1465 (25.33/16.77)	QVT.SPTMTAASTLLR
 1476- 1491 (22.93/14.39)	QCTlFPAITDLLTNLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13461 with Med14 domain of Kingdom Metazoa
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