<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13460

Description mediator of RNA polymerase II transcription subunit 14 isoform X1
SequenceMAPTPLPLPLPLEQMPGVGGGGGGYLPAGQEGGPRINTMSMSVLIDFIIQRTYHELTVLAELLPRKTDMERKVEIYDYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPAEKRQTLLRLNQVIQHRLVTGKLLPQMREFRIRNGRVTFEVKHEFSVSLTVMGDNPTVPWRLLDIDVLVEDKETGDGKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNITVEEYVPGVKLTVSYWRDLKSELGYRLTVQSDPSEIGRPLAVVHVPSLGAKESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLSPCLRAEQIHITIDTHTGMFRCHVPKHLDCPITEEMQDCLNGDRGKLPALLSELRFWITHRRCDKTLQHLPATATETLPFLTPPEQELLQPGRHKIYVKLHRHPNIVLVVQLKEKSTMPNEMEYTFHLGFVAFQKDEQDVIDDSAKQLVSVVAQPHSDIPKCYSKLMRLIEFDTFVATHGPGTEVDAEVSPHKRKSNGDLLAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFMNLAQTLSKHNIPHSGLQVEANATSLVLKILALPQPGKTTFVNQQQQQQGPAAGTGENKPSGASGLPKIEPHVWDDLMRRVLSISVRSQTNKNSQVRIWVVEFVFYSTPLQSSHQKEQGSRRTVYLTYEQANHDFSKTVEDLLNDWSKIVYLYTLVYDFAEQLRNKRLSLCDMLVVKSYSYMNLLLGYGPKKEVSCNIYWSVQSHGFRLTFVGGMSAVNAHSMMRDQLAQHLNQQHSLTQIAQILHETYNPMSSIAKLPVLPFLGIPRPQVPVLSFCMLAQSPCLMRLTYQAVYCLELRFRANRLVSIRDGASSRFERNVVEEFTPIQGLKAFLSKYVDESAAYRGRAAHEDDNPLSPMEDAFGGPSSVAGVSAGGSSPFLCTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGAAGGSGAQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHKSTGGGAGGAGGPDRAGSRVTLNRPWAGAVPTLLTHEALETLCRPSPHPNKDINVPDMSPLERFLGCVYMRRQLHRNIQSEETLTALNSTEPGVVLFKVDGLQCQVVLNQMHMQTLHLKISQLPPMPDKLPPPFQLSQDDLMVIEQYFDTRVAAPPYRPNSLHSICRLLNLPAQVLKDFVQIMRLELKPELGGDQLKWTVQMCMRMPPSAVPIVPIGNACVVLGRMKILFFLQITRIPYGAGMGVPKDWKDSPSLVLPIVYDIQTNVTQMAERTGQVTSPTMTAASTLLRRFAEFNAQQNQCTLFPAITDLLTNLQLATEMPQPPPNQSIGPPVGVGVGVGVGVGSSPNPMMPMQQLQPQQVGPQGPVGPGVYPQMGPNPGGPQ
Length1560
PositionTail
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.07
Grand average of hydropathy-0.268
Instability index54.91
Isoelectric point8.34
Molecular weight173122.23
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13460
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.68|      20|      39|    1061|    1080|       1
---------------------------------------------------------------------------
 1036- 1055 (32.40/11.57)	AGGSSP.FLCTG..MRGPQSPRD
 1061- 1080 (44.62/18.98)	PAPHTP.PSSSN..PHTPASPHP
 1102- 1124 (33.67/12.34)	PAPHMPhPSPSGlmPSSPLNPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.62|      22|      23|    1131|    1152|       2
---------------------------------------------------------------------------
 1131- 1152 (41.04/21.79)	SPGPNTLYMQSHQDSPFTAMSP
 1157- 1174 (37.50/19.16)	WPGSPS..MP..RPSPRPGQSP
 1186- 1207 (37.07/18.84)	AGGPDRAGSRVTLNRPWAGAVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.21|      28|      30|      34|      62|       3
---------------------------------------------------------------------------
   34-   62 (45.00/52.90)	PRINTMSMSVLI.DFiIQRTYHELTVLAEL
   64-   92 (45.21/45.67)	PRKTDMERKVEIyDY.AARTRHLFTRLNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.75|      14|      29|     155|     168|       4
---------------------------------------------------------------------------
  155-  168 (26.14/16.97)	TYNRLPTCIRERIV
  181-  194 (23.62/14.60)	TLLRLNQVIQHRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.46|      12|      30|    1497|    1508|       5
---------------------------------------------------------------------------
  695-  713 (19.08/ 6.82)	LP..QPgkttfvnQQQQQQGP
 1497- 1508 (27.37/13.64)	MP..QP.......PPNQSIGP
 1528- 1540 (20.02/ 7.60)	MPmqQL.......QP.QQVGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.92|      22|      30|     289|     310|       6
---------------------------------------------------------------------------
  283-  306 (34.91/23.19)	YNCL.......hyFCQSLQLEVLYTQTLR..LN
  307-  339 (28.01/17.04)	YERLddnnitveeYVPGVKLTVSYWRDLKseLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.86|      16|      23|     786|     806|       7
---------------------------------------------------------------------------
  786-  806 (16.58/28.44)	VYLtYEQAnHDFSktvEDLLN
  812-  827 (30.27/20.43)	VYL.YTLV.YDFA...EQLRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.63|      22|      23|     475|     497|       9
---------------------------------------------------------------------------
  475-  497 (34.04/25.44)	KLPALLSELRFWITHRRcDKTLQ
  498-  519 (38.59/23.00)	HLPATATETLPFLTPPE.QELLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.48|      14|      31|    1509|    1526|      10
---------------------------------------------------------------------------
 1509- 1526 (23.91/16.47)	PVGVGVGVGVGvgssPNP
 1543- 1556 (32.58/13.96)	PVGPGVYPQMG....PNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.88|      26|      29|    1284|    1312|      11
---------------------------------------------------------------------------
  926-  945 (26.97/ 7.76)	LGI..........PRPQVPVLSFCMLAQSP......
 1284- 1309 (48.12/23.69)	LNQ..........MHMQTLHLKISQLPPMPDKLPPP
 1320- 1354 (33.79/16.20)	IEQyfdtrvaappYRPNSLH.SICRLLNLPAQVLKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.22|      20|      23|     734|     755|      12
---------------------------------------------------------------------------
  734-  755 (29.49/22.71)	HVWddLMRRVL.SISVRSQTNKN
  759-  779 (30.73/16.84)	RIW..VVEFVFySTPLQSSHQKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.48|      23|      28|     972|     995|      14
---------------------------------------------------------------------------
  972-  995 (34.77/26.04)	DGASSRfERNVVEEFTPIQGLK.AF
 1002- 1025 (36.71/22.13)	ESAAYR.GRAAHEDDNPLSPMEdAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.26|      15|      23|    1452|    1466|      15
---------------------------------------------------------------------------
 1452- 1466 (25.33/17.37)	QVT.SPTMTAASTLLR
 1477- 1492 (22.93/14.89)	QCTlFPAITDLLTNLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.22|      19|      30|    1367|    1386|      16
---------------------------------------------------------------------------
 1367- 1386 (31.94/29.68)	LGGDQLKWTVQMcMRMPPSA
 1399- 1417 (32.00/22.25)	LGRMKILFFLQI.TRIPYGA
 1419- 1430 (18.28/ 8.72)	MGVPK.DW......KDSPS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.43|      14|      29|     344|     359|      19
---------------------------------------------------------------------------
  344-  359 (19.38/21.66)	VQSDPSEIGRplAVVH
  376-  389 (24.05/16.94)	VRSEHLSMER..LIVH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13460 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGGSSPFLCTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGAAGGSGAQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHKSTGGGAGGAGGPDRAGSRVTLNRPWAGAVP
2) LQLATEMPQPPPNQSIGPPVGVGVGVGVGVGSSPNPMMPMQQLQPQQVGPQGPVGPGVYPQMGPNPGGPQ
1036
1491
1207
1560










Molecular Recognition Features






MoRF SequenceStartStop




NANANA