<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13455

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFYALTDLCGIKWRKFVNGERPNAPSDPLTDPILRSYSRCIRADMLCVWRRVQSTKTDNAEPNALTFEIATSTKVHPPLSLAAAKELWIFWYGEEPDLKDLVDAELLRVAANQALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLAEAAAAFAAASSPPGSTGSAAATAGGGAVPNPGQDPNGAGIEPLDGGEGGAAKAAPPAHARKVMLAPFGIAAILTGNSYKASDPIAEKILEDWASFFPLCNKDNTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFIEMQKMQSSVGGAAAEAAVLSSLSCPPGAASAPPSSLGAGVGVAAGPSSATAIPVGPASLNAPGGGGAAAASASSASTKEASRKAAPQAVSALERLAFQPYYDQRPTSGFTFNTNNTHIPASAAVEMPERTWQDCVMNTLHVDAAAAAAAAAAATSAVASSTPSAGSGPPADGNDENEQNKPPQQQDSKQLVQQQIQQQQQQQQRQKLWNFVDPMQKAPCICTNAQCSSSSNSNSSSSSSNSSNINIINNKRQQQSLGSPALRAAVTGASGNKSSSSSSSSSSSSATSYQQHYHQQHLQQQQQQQRPGTPVPSAATAAAAATSQHHSSSLSNTSASNSSATAALLRRHNVPFHKRLLHSLASTASSSSTSSSGAFRAKNHSNTTTDTNIPKQRHLGNTPHGTPHGGASTYSRNSLGGDSSMPVASVESPATPAPSPHPNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDSKSITASPYVHQTPSVEPPSYTDHAAGGGGAAGGQSLGTGPGSVPTQQPATPTAASSAGGAGPGGAGNAMGGGSTVGTISVKKLEMQQQQQNPTAAAMAIKQEPGTQGRGTAGGVTSTAEALNNLRRLYSPPKLTLKDPDSFYDDEWLKEVIYDFQYQENWDYLTVKRPKLDEVSKQRRPRYAKNLYEGHTHVKPLMPSPGSVYGSQLLSLDVSANSAGVGGSAAGSSSGGLVGIANSTANGGDAEAESGSSFFPGLDIKTEPGLHSPSCKDTSKSSGGGNSSGGGSGGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVTNTIEDLKRSTAVASAVVAAAAAAAAAAAAASGAGNIQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTTTTSITCSSGGSGITTSCNTTSITSSINTSSTTGCSSSNTSSSIILAAVQQQAPVAMVAIQTVSSKLVKQEYNLELGSPKEEAIEDWNFVYRPPQQEKFVGSTRYAPLTNLPSQTQPPLNLPPECYYQPTWSSHKSRAATLAKAAAAQQQQHQKHQALQQRIQLHQQKLQQFQHQHHQQQQQAAAAAAAAAGGGGHQKHQQHQHQHLHDLLSAAPRTPLTPSTVPQPLSSGGSQLLLNQLNCPQAPPGSSMQQLMQRAGMSPISPGPGMGPYGARSSPMSRQTPTHPPPPYPYDLAVASPATSTSSYLNRPLHSQEHPGAMHGMGGGGGGGGAGGMGSGAGGGGGGHMGMMPYTGDAGIASGGGSATATAAGSSSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGISFNPFPSGGGATGGGGAGGGAGQRVVNGPSSAGGGFGGMRMLSAFGGSPASASMPGAGSGHGHGPNGGSNSSSCTPPSSYPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGIADDPGRNKQPSLLSIIQSLSRKNQMKQQGPGGEPSSALEKAGGAGGVAGGQLEQLAHAIFDLLLDQCSTIQTSSSSVHRALQAHRRRMSRQRRIFGTNGAPTASLASIANVLEFMDAHDVISLALEQARLAFENQRMDNMMDFHGNGSSSSHQQQQLTAFHAPPPALRHKLAGIGAGRLTVHKWSYLPVGFTRSNKEIVRTMNAIQPMLQNAFHCKSRGGSGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVVVGYEKDWISVAPQSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVVSCTRSYFRELGSTYEMCKLGKHTPIRGWDGILQVGAARNVPADRETTPLDDWLRTLEHAALAEQIRRYAVAFIHQLAPYLSRVPNDKTLLNPPDGTGNSNSKGGSSSSSNTSSASGLPGGDLPTDNIKLEPGTEPPVQPMDTNEIKQEPGAAGKGTSAAGDTKPALILGDPLGMGETLEDINPSAIVLYVVNPFTFASDSSELERLALIALLRCYAELLKAVPDSVRAQMNIQIISLESVMELGPCGNRKRFSDEIKCLALNIFSQCRRHLVHAQSVKSLTGFGTAAKMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGELLEKICINIDVPNRARRRKAPARYVALKKLMDFIMGIISQTSQMWRLVIGRIGRIGHSELKSWSYLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLATPQDVTCTHILVFPTSAVCAPFTRQFQNEPQVDDDFLTFEEEGNEDFSDADIGDLFWDPHIDRVSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQTADDILNSTNAHQSANDHPLDSILTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2859
PositionMiddle
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.408
Instability index54.49
Isoelectric point6.37
Molecular weight302409.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13455
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     269.64|      38|      38|     885|     922|       1
---------------------------------------------------------------------------
  402-  434 (30.86/ 7.10)	LGAGVGVAA....G.....PSSA.TAIPVGP..A.slnapGGGGAA....
  872-  894 (30.34/ 6.84)	........P....SVEP..PSYTDHA.......A......GGGGAAGGQS
  895-  932 (70.82/27.21)	LGTGPGSVP....TQQPATPTAASSAGGAGP..G......GAGNAMGGGS
  934-  979 (31.11/ 7.22)	VGTI..SVKklemQQQQQNPTAAAMAIKQEP..GtqgrgtAGGVTSTAEA
 1117- 1140 (30.65/ 6.99)	IKTEPG.......LHSPSCKDTSKSSG...................GGNS
 1583- 1607 (33.10/ 8.22)	........P....LHSQEHPGAMHGM...GG..G......GGGGGAGG..
 1608- 1637 (42.77/13.09)	MGSGAGG............GGGGHM..GMMPytG......DAGIASGGGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     521.14|     152|     942|     684|     843|       2
---------------------------------------------------------------------------
  588-  677 (79.51/24.30)	.........................................................................................................................................TN...AQCSSS.SNSNSSSSSSNSSNI...NIINNKRQQQSLGSP........AlraavtgasgnkSSSSSSSSSS......SSATSYQQHYHQQHLQQQqqqqrP.GTPVP
  678-  770 (126.69/53.64)	SAAT................................................................................................................................aaAAATS...QHHSSSLSNTSASNSSATAALLRRHNVPFHKRLLHSLAST........A............SSSSTSSSGAfraknhSNTTTDTNIPKQRHLGNT.....PhGTPHG
  771-  862 (108.74/37.56)	GASTYSRNSLGGDS........S.................MPVASVESPATPAPS.PHP.NSAHSQ........PtSVPPA...EQLLN...MSP.............HAPTSVSNLQQPPTPIDHLldkntpaPTPTD...QHDSKSI....................................................................................................
 1219- 1315 (95.44/29.80)	AAAAAAAAAASGAGniqaedltK.................M...FP.TP..PSHEqQHP.NS.....................................................SPCQ..................TDvvmTDLSVDTTTTSITCSSGGSGITTSCN.......TTSITSSintssttgC............SSSNTSSS......................................
 1455- 1562 (49.13/10.96)	AAAAAAAAAGGGGH........Q.....khqqhqhqhlhdLLSAAPRTPLTPSTV.PQPlSSGGSQlllnqlncP.QAPPGssmQQLMQragMSPispgpgmgpygarSSPMSRQTPTHPPPP..............................................................................................................................
 1718- 1792 (61.62/16.04)	GGATGGGGAGGGAG........QrvvngpssagggfggmrMLSAFGGSPASAS.M.PGA.GSGHGH...........................GP.............NGG.SNSSSCTPPSSYPHI..........................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.22|      27|     942|     215|     260|       3
---------------------------------------------------------------------------
  227-  253 (49.45/33.41)	EAAAAFAAASSPPGSTGSAAATAGGGA
  508-  534 (43.77/11.62)	DAAAAAAAAAAATSAVASSTPSAGSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.85|      20|      20|    1073|    1092|       4
---------------------------------------------------------------------------
 1073- 1092 (34.18/17.08)	ANSAGVGGSA.AGSSSGGLVG
 1094- 1114 (31.93/15.32)	ANSTANGGDAeAESGSSFFPG
 2236- 2254 (26.74/11.28)	.NSNSKGGSS.SSSNTSSASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.15|      13|      23|    1420|    1432|       5
---------------------------------------------------------------------------
 1427- 1448 (20.11/ 7.80)	HQALQQ........riqlhqqklQQFQHQH
 1449- 1478 (19.04/ 7.00)	HQQQQQaaaaaaaaagggghqkhQQHQHQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.96|      18|      33|      31|      48|       6
---------------------------------------------------------------------------
   31-   48 (34.69/19.62)	WRKFVNGERPNAPSDPLT
   67-   84 (32.27/17.68)	WRRVQSTKTDNAEPNALT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.48|      14|      15|     542|     555|       7
---------------------------------------------------------------------------
  542-  555 (25.46/15.22)	NEQNKPPQQQDSKQ
  558-  571 (25.02/14.81)	QQQIQQQQQQQQRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.84|      14|      34|     451|     464|      10
---------------------------------------------------------------------------
  435-  448 (19.11/ 9.02)	AASASSASTKEASR
  451-  464 (23.08/12.71)	APQAVSALERLAFQ
  486-  498 (22.64/12.30)	ASAAVEMPER.TWQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.73|      12|      23|    1794|    1806|      12
---------------------------------------------------------------------------
 1794- 1806 (20.30/18.89)	GYVDDDPVECTcG
 1820- 1831 (22.42/13.63)	GLFYEDEVEIT.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.73|      45|     870|    1930|    1975|      19
---------------------------------------------------------------------------
 1930- 1975 (73.36/58.07)	NGAPTASLASiANVLEF.MDAHDVIS.LALE...QARLAFENQRMDNMMDF
 2802- 2851 (64.37/45.44)	NDHPLDSILT.ADVLRFvLEGYNALSwLALDsntHDRLSCLPINVQTLMDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13455 with Med13 domain of Kingdom Metazoa
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