<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13453

Description LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 26
SequenceMNQNQIQQLTTHLSQALDQNYDVVNMEAVLSVICALEGTTITKEQLEATRLAKYINQLRRRTKNETLARRAKSLLKKWREMVGIQQTATEVVPTLPPKPLADLSKSTMIAPPEHLGESVNHLSFSQSLADQQIISNVQSNIEASELAPLGLNTQLNTNFSNHVYNMPDESNSITTAVLNCRDQCLPTGSPQPGVIIEQPLNSVLNLTGNSTAEKLTDVASVVIDIVSDSDENDNNCGSKPEIYNSIVSDPIAIPSTPSSRQKKXKKEKRIKQKEGQAAQNIKLLQSALATDSEIFSLSNSSMSSILSGEAATLGNSKKTRLSSSELTFTGRFKSLNQNDLTTQSNSSFLAEQNGVLARSNLLESGKPKLDEYNAYDSSASCSRLSPSTVEDIKKMDNVIDLKLHSASMPDPGTGCDPNSRHRYLENASQSQIPKRRGRKKGSKGVDAVIAKESSSLSQQIFFGGSTVKKVKTTKELFNEIQSRKFSVSMQSSASNCSNSSIKREQAGRAIFPRPTSSCSDTSMHSPQILETFTNQTQDPTNTDSDTVTSEPSRDSNKSEEIKECSSLDSNSNSNNNLHLANNLDNLMPTNFHDITTQLVHLIHSLNSPLTAVEIEKIYQTQLVPCTCVVIEEVPRTLGASNPLNSDAETNNQNVNLSYQENLFSHNTEENLTALERNGVDEEGESQAKPVKSIFDLDFDDNDDPLHSILDDTRKTMDKVDHLKSFQATKNEVVNVALHLVNSSAETKLNNQQQSQERDNNETNSAVLPVFNVLEDPNCVAKQQFYVQTNQITNFHINALHNFYIPNINGNWDIADSNPNFQSQSHFLHTLDSYSVTDGADVVPKYGHHTIDRIRKDLTSLKFIKPFKAKPFKFIMSPFLGVAKCLPTCRRAKRMYRQCFGSKMISDKFPKKRKPKVNIPSPLNVNIDVPISGINSHHHVPTTQVNSVLKKTTLSTPVLDSCSSVNGFSNNLLKLADNEIQFGEAEINDKSSGHEYQDTSSSSCSYASLNETQDSNNKKNVRNRSISRKSEASKRNKGIHGGDVTKKKKYENYELDAPLKRIKKAFNSTSNSDNDSDNGAENDNNKEEYAIVQRPIVDGVAFNNHIVLTIKKTPSKINSPANSMPMAVSPNNTLAAEKVNKIISISHLQDSPTSQNKSNVALKNNLITKKIRITPRPLQNCYRRTSRKPVKGQRKTIDLELKHLFRLSPEAAPASSSKVKIHNKLFFHHELCRENPEGMEERIINYSSSSSSSSYDDDSEADNSPSEEEMKPTKLSAFDVYQMDIETESSDSTEISEVQVESEEDSFLNSLYDKEARPEKYESVDDDELNDFQNNRMLQSFNSIFATNQESSPPRASLTERENENSDANNIYFNNNNINVSNIHRKSMEPSQEEYRTGVRSVLDSPPPTSVADMDLTRIQQFKEWHQVLQLKSYNNEPLIVLPYVLLE
Length1447
PositionUnknown
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.715
Instability index51.06
Isoelectric point6.04
Molecular weight161143.37
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13453
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.77|      16|     396|     564|     582|       1
---------------------------------------------------------------------------
  564-  581 (26.84/13.62)	CSSLdsNSNSNNNLHLAN
  961-  976 (27.93/ 9.06)	CSSV..NGFSNNLLKLAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.48|      24|      31|    1287|    1311|       2
---------------------------------------------------------------------------
 1247- 1265 (26.45/11.76)	.SSSSS..SSYDDDSEAD...NSPS
 1287- 1311 (36.20/23.47)	ESSDSTEISEVQVESEEDSFlNSLY
 1321- 1344 (39.83/21.75)	ESVDDDELNDFQNNRMLQSF.NSIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     412.03|     122|     197|     151|     345|       3
---------------------------------------------------------------------------
  201-  331 (172.06/150.87)	NSVLNLTGNSTAEKLTDVASVVIDIVSdsdenDNNCGSKPEIyNSIVSdpIA.IPSTPSSRQ.....KK..xKKEKRIKQK...EGQAAQN.I..KLLQSALATDSEIFSLSNSSMSSILSGEAA...TLGNSKKTRLSSSEL..TFTGR
  449-  535 (78.66/19.79)	..................................................IA.KESSSLSQQiffggST...VKK..VK.....TTKELFNeI..QSRKFSVSMQSSASNCSNSSIKREQAGRAIfprPTSSCSDTSMHSPQIleTFTNQ
 1102- 1226 (161.31/64.78)	NNHIVLTIKKTPSKINSPANSMPMAVS.....PNNTLAAEKV.NKIIS..IShLQDSPTSQN.....KSnvaLKNNLITKKiriTPRPLQN.CyrRTSRKPVKGQRKTIDLELKHLFR.LSPEAA...P.ASSSKVKI.HNKL..FF...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.92|      24|      27|     996|    1022|       4
---------------------------------------------------------------------------
  999- 1022 (41.92/31.96)	SSSSCSYAS.LNE...TQDSNNKKNVRN
 1024- 1051 (31.01/13.28)	SISRKSEASkRNKgihGGDVTKKKKYEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.91|      23|      27|     793|     818|       5
---------------------------------------------------------------------------
  793-  818 (38.15/38.13)	NFHINA..LHNFYIPNINgnwDIADSNP
  819-  843 (35.76/23.92)	NFQSQShfLHTLDSYSVT...DGADVVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.26|      21|      45|     865|     886|       6
---------------------------------------------------------------------------
  865-  886 (36.64/34.79)	PFKAKPFKFIMSPfLGVAKCLP
  909-  929 (39.62/30.93)	PKKRKPKVNIPSP.LNVNIDVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.38|      23|      45|      85|     107|       7
---------------------------------------------------------------------------
   85-  107 (38.45/23.17)	QQTATEVVPTLPPKPLADLSKST
  131-  153 (36.93/21.95)	QQIISNVQSNIEASELAPLGLNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      92.67|      17|     104|     639|     655|       9
---------------------------------------------------------------------------
  639-  655 (25.71/13.47)	ASNPLNSDAETNNQNVN
  701-  717 (22.09/10.40)	NDDPLHSILDDTRKTMD
  718-  734 (22.29/10.57)	KVDHLKSFQATKNEVVN
  744-  760 (22.58/10.81)	AETKLNNQQQSQERDNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.73|      30|     397|     666|     695|      11
---------------------------------------------------------------------------
  666-  695 (48.30/33.43)	NTEENLTALERNGVDEEGESQAKPVKSIFD
 1374- 1403 (50.43/35.27)	NNNINVSNIHRKSMEPSQEEYRTGVRSVLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13453 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLKLHSASMPDPGTGCDPNSRHRYLENASQSQIPKRRGRKKGSKGVDAVI
2) EGMEERIINYSSSSSSSSYDDDSEADNSPSEEEMKPTKLSAFDVYQMDIETESSDSTEISEVQVESEEDSFLNSLYDKEARPEKYESVDDDELNDFQ
3) GEAEINDKSSGHEYQDTSSSSCSYASLNETQDSNNKKNVRNRSISRKSEASKRNKGIHGGDVTKKKKYENY
4) NIHRKSMEPSQEEYRTGVRSVLDSPPPTSVADMDL
5) RIKKAFNSTSNSDNDSDNGAENDNNKEEYAIVQR
6) SFNSIFATNQESSPPRASLTERENENSDANNIYFN
7) SSASNCSNSSIKREQAGRAIFPRPTSSCSDTSMHSPQILETFTNQTQDPTNTDSDTVTSEPSRDSNKSEEIKECSSLDSNSNSNNNLHLANNLDNL
400
1236
982
1381
1060
1339
491
449
1332
1052
1415
1093
1373
586










Molecular Recognition Features






MoRF SequenceStartStop




NANANA