<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13448

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFYALTDLCGIKWRKFVNGERPNAPSDPLTDPILRSYSRCIRADMLCVWRRVQSTKTDNAEPNALTFEIATSTKVHPPLSLAAAKELWIFWYGEEPDLKDLVDAELLRVAANQALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLAEAAAAFAAASSPPGSTGSAAATAGGGAVPNPGQDPNGAGIEPLDGGEGGAAKAAPPAHARKVMLAPFGIAAILTGNSYKASDPIAEKILEDWASFFPLCNKDNTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFIEMQKMQSSVGGAAAEAAVLSSLSCPPGAASAPPSSLGAGVGVAAGPSSATAIPVGPASLNAPGGGGAAAASASSASTKEASRKAAPQAVSALERLAFQPYYDQRPTSGFTFNTNNTHIPASAAVEMPERTWQDCVMNTLHVDAAAAAAAAAAATSAVASSTPSAGSGPPADGNDENEQNKPPQQQDSKQLVQQQIQQQQQQQQRQKLWNFVDPMQKAPCICTKHLGNTPHGTPHGGASTYSRNSLGGDSSMPVASVESPATPAPSPHPNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDSKSITASPYVHQTPSVEPPSYTDHAAGGGGAAGGQSLGTGPGSVPTQQPATPTAASSAGGAGPGGAGNAMGGGSTVGTISVKKLEMQQQQQNPTAAAMAIKQEPGTQGRGTAGGVTSTAEALNNLRRLYSPPKLTLKDPDSFYDDEWLKEVIYDFQYQENWDYLTVKRPKLDEVSKQRRPRYAKNLYEGHTHVKPLMPSPGSVYGSQLLSLDVSANSAGVGGSAAGSSSGGLVGIANSTANGGDAEAESGSSFFPGLDIKTEPGLHSPSCKDTSKSSGGGNSSGGGSGGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVTNTIEDLKRSTAVASAVVAAAAAAAAAAAAASGAGNIQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTTTTSITCSSGGSGITTSCNTTSITSSINTSSTTGCSSSNTSSSIILAAVQQQAPVAMVAIQTVSSKLVKQEYNLELGSPKEEAIEDWNFVYRPPQQEKFVGSTRYAPLTNLPSQTQPPLNLPPECYYQPTWSSHKSRAATLAKAAAAQQQQHQKHQALQQRIQLHQQKLQQFQHQHHQQQQQAAAAAAAAAGGGGHQKHQQHQHQHLHDLLSAAPRTPLTPSTVPQPLSSGGSQLLLNQLNCPQAPPGSSMQQLMQRAGMSPISPGPGMGPYGARSSPMSRQTPTHPPPPYPYDLAVASPATSTSSYLNRPLHSQEHPGAMHGMGGGGGGGGAGGMGSGAGGGGGGHMGMMPYTGDAGIASGGGSATATAAGSSSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGISFNPFPSGGGATGGGGAGGGAGQRVVNGPSSAGGGFGGMRMLSAFGGSPASASMPGAGSGHGHGPNGGSNSSSCTPPSSYPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGIADDPGRNKQPSLLSIIQSLSRKNQMKQQGPGGEPSSALEKAGGAGGVAGGQLEQLAHAIFDLLLDQCSTIQTSSSSVHRALQAHRRRMSRQRRIFGTNGAPTASLASIANVLEFMDAHDVISLALEQARLAFENQRMDNMMDFHGNGSSSSHQQQQLTAFHAPPPALRHKLAGIGAGRLTVHKWSYLPVGFTRSNKEIVRTMNAIQPMLQNAFHCKSRGGSGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVVVGYEKDWISVAPQSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVVSCTRSYFRELGSTYEMCKLGKHTPIRGWDGILQVGAARNVPADRETTPLDDWLRTLEHAALAEQIRRYAVAFIHQLAPYLSRVPNDKTLLNPPDGTGNSNSKGGSSSSSNTSSASGLPGGDLPTDNIKLEPGTEPPVQPMDTNEIKQEPGAAGKGTSAAGDTKPALILGDPLGMGETLEDINPSAIVLYVVNPFTFASDSSELERLALIALLRCYAELLKAVPDSVRAQMNIQIISLESVMELGPCGNRKRFSDEIKCLALNIFSQCRRHLVHAQSVKSLTGFGTAAKMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGELLEKICINIDVPNRARRRKAPARYVALKKLMDFIMGIISQTSQMWRLVIGRIGRIGHSELKSWSYLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLATPQDVTCTHILVFPTSAVCAPFTRQFQNEPQVDDDFLTFEEEGNEDFSDADIGDLFWDPHIDRVSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQTADDILNSTNAHQSANDHPLDSILTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2690
PositionMiddle
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.379
Instability index52.05
Isoelectric point6.10
Molecular weight284974.20
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13448
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     362.64|      68|     112|    1421|    1488|       1
---------------------------------------------------------------------------
  588-  655 (52.30/14.34)	........................................................TKH...LG......NTPHGTPHG.........GAStysrnSLGGDssMPV............AsvesPaTP...APS.PH.PNS............AHSQPTSVPPAeQ......LLNMSP
  704-  747 (54.57/15.30)	SVEP.................................................PSYTDH.................AAG.........GGG.....AAGGQ.sLGT............G....P.GS...VPT.Q.................QPATPTAASSA..............
  839-  902 (45.50/11.45)	EVIY....................................dfqyqenwdyltvKR.........PK.LDEVSKQRRPRY.........AKN.....LYEGH..THV............K....P.LM...PSP.G......................SVYG.S.Q......LLSLDV
  903-  961 (42.36/10.12)	S....................................................................ANSAGVGGSA.........AGS.....SSGGL..VGI............A....N.STangGDA.EAESGSsffpgldiktepGLHSPSC..............KD..
 1421- 1484 (111.34/39.36)	.....................................................PGAMHG...MGGG.GGGGGAGGMGSG.........AGG.....GGGGH..MGM............M....P.YT...GDA.GIASGG............GSATATAAGSS.S......LLQELP
 1485- 1631 (56.56/16.14)	EVNSvlvnillydtalnvfrdhnfdsssvcvcnadtqkignirgadsgvyvplPGISFNpfpSGGGaTGGGGAGG.GAGqrvvngpssAGG.....GFGG...MRMlsafggspasasM....P.GA...GSGhGHGPNG............GSNSSSCTPPS.SyphitgYVDDDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     256.68|      38|     235|    1051|    1088|       2
---------------------------------------------------------------------------
  230-  262 (29.78/ 8.77)	AAFAAassppgstgsAAATAGGG..................AVP.NP......GQDPN..
  376-  402 (42.35/16.32)	GGAAA..........EAAV...................L.SSLS.CP..PGAASAPPSSL
  404-  432 (31.21/ 9.63)	AGVGV..........AAGPSSATAIPV.........GPASLNAP.GG..GG.........
  510-  535 (34.03/11.32)	AAAAA..........AAAAATSAV..A.........SSTPSAGS.GP..P..........
 1051- 1088 (70.01/32.94)	AAAAA..........AAAASGAGNIQA.........EDLTKMFP.TP..PSHEQQHPNSS
 1286- 1333 (49.29/20.49)	AAAAA..........AAAAGGGGH.QKhqqhqhqhlHDLLSAAPrTPltPSTVPQ.PLSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.61|      12|      15|    1105|    1119|       3
---------------------------------------------------------------------------
 1105- 1116 (24.14/ 9.44)	TTSITCSSGGSG
 1123- 1134 (20.48/11.47)	TTSITSSINTSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.94|      24|      28|    1365|    1389|       4
---------------------------------------------------------------------------
 1350- 1367 (31.65/12.96)	PGSS....MQQL......MQR.AGMSPIS
 1368- 1392 (46.18/27.27)	PGPG....MGPYGARSSPMSRqTPTHPPP
 1393- 1416 (26.12/ 9.14)	PYPYdlavASPATSTSSYLNR..PLH...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.75|      13|      23|    1251|    1263|       5
---------------------------------------------------------------------------
  554-  566 (21.30/10.39)	KQLVQQQIQQQQQ
 1251- 1263 (25.33/13.96)	QQQQHQKHQALQQ
 1273- 1285 (30.12/18.21)	QQFQHQHHQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.66|      21|      35|      26|      48|       6
---------------------------------------------------------------------------
   26-   48 (36.92/29.99)	LCGikWRKFVNGERPNAPSDPLT
   64-   84 (38.75/24.64)	LCV..WRRVQSTKTDNAEPNALT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     195.86|      54|     646|     982|    1037|       7
---------------------------------------------------------------------------
  752-  788 (50.86/22.03)	...PG...............GAGNAMGGGSTVGT....................iSVKKLE.MQQQQQNPTAAAMA
  789-  833 (54.05/23.92)	IKQEP...............GTQ..GRGTAGGVTSTAEalnNLRR.lYSPPKL..TLKDPDSFYD...........
  948- 1010 (58.04/31.85)	IKTEPglhspsckdtskssgG.GNSSGGGSGGG............nlFTAEGLnpSLNDLEQLFETSSNDECSSVQ
 1011- 1037 (32.92/10.89)	IHTPP...............DSNNPSNGGCSAVTNTIE...DLKR...............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.78|      35|     550|     656|     694|       8
---------------------------------------------------------------------------
  656-  694 (53.40/40.60)	HAP.TSVSNLQQPPTpidHLLDKNTPAPTPTdQHDSKSIT
 1208- 1243 (60.39/33.23)	YAPlTNLPSQTQPPL...NLPPECYYQPTWS.SHKSRAAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.75|      16|     591|    1138|    1153|      11
---------------------------------------------------------------------------
 1138- 1153 (27.68/17.35)	CSSSNTSSSIILAAVQ
 1730- 1745 (29.07/18.64)	CSTIQTSSSSVHRALQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.82|      10|      27|      97|     106|      12
---------------------------------------------------------------------------
   97-  106 (17.48/11.23)	LSLAAAKELW
  125-  134 (18.34/12.23)	LRVAANQALW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.50|      15|    1342|    1180|    1205|      13
---------------------------------------------------------------------------
 1191- 1205 (30.12/28.71)	NFVYRPPQQEKFVGS
 2552- 2566 (29.38/ 7.26)	NFKCTPPQEVEEVGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13448 with Med13 domain of Kingdom Metazoa
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