<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13444

Description mediator of RNA polymerase II transcription subunit 24
SequenceMKENNKILQLIYVAWRERWSDSQWGINIKKVLPRGVSGDVYNLADCLMQQALIGSTANPLVLNYLKHSLCAHLVSHAAVLRCIAKYDKLERVYCITSLLEFLASIVDGVTCRIKAEEAVLPSSVVHLVYWLLQIFARTVQHYELYGEISAEQSYMLDQTCVVIDRLSQHQFLLSMLYVGCHEELEIRGRIRDKYASIKGSLTNSNFTLNAPNVEQQLQQLAYIEGKHLDMQPLNPQATQEKISFCVQPLLAVEVLLNPSKDTSFYVAELQMLQRLKRYSNTRLFYEIIRAGFLTLSNVADNSPDTMWGAFMFFKMPHILKQLHALQRIPGDQPPPADYIPELVEALELLIEDNLLLDFMDTKCSCNMIEFLLNDWTKQQLVNDVHVKKFASQREAASQLLKKCDNGQQTPSNINFIKRAEVPLSGVLKTLCTNKVQDMVNVLCQVPVGNSFELILSVATVEGRLTTFVSRLIQCNENSKPVPGELGKQCVIRSTLFDVSFLMLTSIVQTYGSDVVLTERGDSFFEKWVRECMVERNKLKNPRQILALCDDSIVDELLLSLSKPEAAQLKPSNLSCQETCLNLPGVLHHVLIAWEQETLSSADVKSILDNIKRRLFSFSVCATSFLCAYMYSVKETELLKPLNMIQQFLAPLTSEELSSQENANERLALSYQIIRKMQHDVHPAPSTKSRLISHSPLVEQFREVWRTVVDAGHLPVRAAQTLESLLLAGGAAWLSTQLVEQLLACKYTRDMSRAMDVVFAVMHLDIEKTTEALLQYVVAPLILRRQGEDINEPQSLILARLCVYCIISCLESRSGNASFALSAMKKRSRSHDEEELAANAAKVRKVIGGDGSDNSSDFTDSTVGAGLGALLGTTSTAELRTTPLTLREPLQTSVQHIFAVFLQFVSSDELSPKAVFVYQFISLLVECGGDRVAPVLRLLPATLVQQLLKVLVTDDIRVGLISRLYDLRLQAGRQSAVADLCLWRNMQMARHSIHL
Length994
PositionTail
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.07
Grand average of hydropathy0.032
Instability index47.55
Isoelectric point6.30
Molecular weight111746.24
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13444
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.83|      12|      15|     892|     905|       1
---------------------------------------------------------------------------
  892-  905 (14.09/15.39)	SVQHIFaVFlQFVS
  910-  921 (22.74/12.74)	SPKAVF.VY.QFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     650.50|     195|     446|      47|     249|       3
---------------------------------------------------------------------------
   47-  249 (320.87/237.20)	LMQQALIGSTANPLVLNYLKHSLCAHLVSHaavlrCIAKYDKLERVYCITSLLEflASIVDGVTCRI.KAEEAVL.PS..SVVHLVYWLLQIFARTVQHYELYGEISAEQSYMLDQTCVVIDRLS..QHQFLLSMLY.VGCHEELEIRGRI......RDKYASIK.GSLTNSNFTLNAPN.............VEQQLQQLAY..IEGKHLDMQPlNPQATQEKISFCVQPL
  262-  346 (43.56/20.36)	................................................................................................................................TSF.....Y.VA...ELQMLQRLkrysntRLFYEIIRaGFLTLSNVADNSPDtmwgafmffkmphILKQLHALQR..IPG...D.QP..PPA..DYIPELVEAL
  501-  696 (286.06/192.71)	LMLTSIVQTYGSDVVLTERGDSFFEKWVRE.....CMVERNKLKNPRQILALCD..DSIVDELLLSLsKPEAAQLkPSnlSCQETCLNLPGVLHHVLIAWEQETLSSADVKSILDNIKRRLFSFSvcATSFLCAYMYsVKETELLKPLNMI......QQFLA.....PLTSEELS.SQEN.............ANERL.ALSYqiIRKMQHDVHP.APSTKSRLISH..SPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.90|      16|      16|     710|     725|       4
---------------------------------------------------------------------------
  710-  725 (26.63/17.03)	AGHLPVRAAQTLESLL
  727-  742 (27.27/17.62)	AGGAAWLSTQLVEQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.31|      25|      25|     389|     413|       5
---------------------------------------------------------------------------
  389-  413 (43.71/29.56)	FASQREAA.SQLLKK.CDNGQQTPSNI
  415-  441 (34.60/21.88)	FIKRAEVPlSGVLKTlCTNKVQDMVNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.84|      13|      24|     923|     937|       7
---------------------------------------------------------------------------
  923-  937 (17.85/19.03)	LVEcgGD.RVAPVLRL
  950-  963 (17.99/ 9.58)	LVT..DDiRVGLISRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13444 with Med24 domain of Kingdom Metazoa
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