Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSGSNAKSSGTGGFGSHIPSIEEKNKQIQQETMMEKLRAKYRSKPKSYEEIKKSVRMYFIEKHYPLDPVCKATLQSALDKLQHYIKVTSRHGLVERLESLSRQLGLKFMEDQQLLFISTDMFYVEILLDAAGSLSDVKVHHECKIEQQSSELVACLKSGDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDIQSLYQLHLQGHSGDSYSLMNNSSVGLVLPRRGGHPMKLTYFCPPLHLPEGDPKQASGDFTIDQVMRSSHGLSATVNLEGSSANKLQTLPTVTLVRDAQTGLEVPTYAQLNQNNSLLMPATYVLRLNKPMPVCLESLKALGLPGLDATATPPSPPSTVLNLIVQTASKQAIRNTQRGLYVNLPKETHCYFFTDNRKLQGTLVSSLPFTEPAQVPRIMAFLKKQALFYTLLASCVREQQKQYNDMDSTVILEVTAVSFNQITVELQHPYEESLATVDFLLEDGQPTCSVYCLTNEYEQLSQKLTRTVRKVVSIPMVIYKLLKCWDEEHEFKLHGVIGPGAGAAGSGPIGGGAGMGGGTVTGGGNNFNQFAMDTAPPSDGNLPGGGFANISNLKLDAKSRSLADAFAASTSAAAAIAGLINLKRETDPHSGSSGSGASTSGSSSSSGAAKTSDHDIADKYKNIWKDKTPNLKHCVSITPIPGDGKAAGPTGVVPGVEVQRTGGIEIIPLNTQAAVTGGGVAAPSGAAPTTITITPITGKDPSKDSSKKSGATSTGVGVATKRPHESGSGGSSTSGSGGSGSAMSSSSSSSSDMQKEKKRKKKRDDSPMGPPEKIYSRQNSPAAGGDGSAPGGVVRKFSSPSSSPKAGGSGQGLMAGVPTARPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHGSSGKPSMSTLKSAATAATILSPKGDKSSSAVGATSSGPSASSASGGAPGLVRSFASVGAPPPPPPIPPLASASGSVGSSQSLKKDKSMPGSSSSSTGSSATATVSSGGGISPASVAAAVAALKSSQQQLKSVASLSHLAAGGGLGSYAASSGAGGSAAAAVVVGAGAGAGAGASGLELSALRKGMAGGAVSLMTSTAALAPTIPVATTTVSAGTAGSAASLAPPASAGVGQGQETAAAVTAAATLATATMLQQQQQPGAGPTSSCLATSGGSSDSAGGSTMAGASTEYMVKPSSQEGLKLTINKTGSSKSSGSGSSSTSGGQVKAKTSSIAVTSTAGSSGATKKQHTGLKPGVNSGPASKKVTAVASAAATSSSKHLFQKANSSGNLSSKLSGSGGGGGVSLTKSNSTNSFQEHSAPRRRPSMGALASGSTGSGSVPRKSSSTSAGASGSSGSVSPALSGSMSQPPPRFDHHTDMMTILQYASPTMAANMEGFIKGLHTKFQIPKLSQRGSGGNTTSGRSTPSGGADIAAAGTSSSISGSAASSIGLADPEAKPPAPPPSTGNEGLLNLSSTAGTQSGDGIDEELLASLAGE |
Length | 1481 |
Position | Middle |
Organism | Drosophila ficusphila (Fruit fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.279 |
Instability index | 49.60 |
Isoelectric point | 9.40 |
Molecular weight | 149561.80 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP13443 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 9| 698.74| 87| 87| 1020| 1106| 1 --------------------------------------------------------------------------- 596- 740 (59.12/10.09) SLadafaAST..........SAAA.AIAG....LinlkretdphsgssG...S.GASTSG...............SSSSSGAAktsdhdiadkykniwkdktpnlkhcvsITPI...PGDGKA.........AGPTGvvpgvevqrtggIEII..PLN..TQAAvtGGGV..A....APSGA.APTtIT.............ITPITGK......D.....................P......SKDS 752- 822 (86.79/18.53) GV.....ATK..........RPHE.SGSG...................G...S...STSG...............SGGSGSAM....................................SSSS.........SSSSD............MQKE..KKR..KKKR..DD....S..PMGPPEKIYSR.................QNSP.A......A.....................G......GDG. 823- 893 (76.86/15.50) .......................S.APGGvvrkF..............S...S.PSSSPK...............AGGS.......................................GQGLM.........AG.................VP..TAR..PSPK..HSPVysS..PKHNTASNSPK.SP.............FGTHSPK......H.....................G......SSGK 901- 1000 (75.51/15.09) SA.....ATAatilspkgdkSSSA.VGAT....S..............S...G.PSASSA...............SGG.APGL...........................VRSF...ASVGAPpppppipplASASG............SVGSsqSLKkdKSMP..GSSS..S.....STGS....................SATATVS......S.....................G......GGIS 1020- 1105 (131.90/32.29) SV.....ASL..........SHLA.AGGG....L..............G...S.YAASSG...............AGGSAAAA...........................VVVG...AGAGAG.........AGASG............LELS..ALR..KGMA..GGAV..S..LMTSTAALAPT.IP.............VATTTVS......A.....................G......TAG. 1106- 1196 (78.78/16.09) SA.....ASL..........APPAsAGVG....Q..............G...QeTAAAVT...............AAATLATA...........................TMLQ.qqQQPGAG.........PTSSC............LATS..GGS..SDSA..GG..........STMAGAST.EY.............MVKPSSQ......E.....................GlkltinKTGS 1197- 1275 (70.32/13.50) .......................S.KSSG....S..............G...S.SSTSGG...............QVKAKTSS...........................IAVT...STAGS..........SGATK............KQHT..GLK..PGVN..SGPA..S....KKVTAVASA.................AATSSSkhlfqkA.....................N......SSGN 1278- 1403 (69.62/13.29) S.......KL..........SGSG.GGGG....V..............SltkS.NSTNSFqehsaprrrpsmgalASGSTGSG...........................SVPR...KSSSTS.........AGASG..........................S..SGSV..S..PALSGSMSQPP..PrfdhhtdmmtilqYASPTMA......AnmegfikglhtkfqipklsqrG......SGGN 1404- 1479 (49.84/ 7.26) TT.....SGR..........STPS.GGAD....I..............A...A.AGTSSS...............ISGSAASS...........................IGLAdpeAKPPAP.........PPSTG........neglLNLS..STA..GTQS..GDGI..DeeLLASLA................................................................... --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IDEELLASLAGE 2) LKSAATAATIL 3) LSALRK 4) SKHLFQK | 1470 899 1067 1263 | 1481 909 1072 1269 |
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