<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13437

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSGSNAKSSGTGGFGSHIPSIEEKNKQIQQETMMEKLRAKYRSKPKSYEEIKKSVRMYFIEKHYPLDPVCKATLQSALDKLQHYIKVTSRHGLVERLESLSRQLGLKFMEDQQLLFISTDMFYVEILLDAAGSLSDVKVHHECKIEQQSSELVACLKSGDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDIQSLYQLHLQGHSGDSYSLMNNSSVGLVLPRRGGHPMKLTYFCPPLHLPEGDPKQASGDFTIDQVMRSSHGLSATVNLEGSSANKLQTLPTVTLVRDAQTGLEVPTYAQLNQNNSLLMPATYVLRLNKPMPVCLESLKALGLPGLDATATPPSPPSTVLNLIVQTASKQAIRNTQRGLYVNLPKETHCYFFTDNRKLQGTLVSSLPFTEPAQVPRIMAFLKKQALFYTLLASCVREQQKQYNDMDSTVILEVTAVSFNQITVELQHPYEESLATVDFLLEDGQPTCSVYCLTNEYEQLSQKLTRTVRKVVSIPMVIYKLLKCWDEEHEFKLHGVIGPGAGAAGSGPIGGGAGMGGGTVTGGGNNFNQFAMDTAPPSDGNLPGGGFANISNLKLDAKSRSLADAFAASTSAAAAIAGLINLKRETDPHSGSSGSGASTSGSSSSSGAAKTSDHDIADKYKNIWKDKTPNLKHCVSITPIPGDGKAAGPTGVVPGVEVQRTGGIEIIPLNTQAAVTGGGVAAPSGAAPTTITITPITGKDPSKDSSKKSGATSTGVGVATKRPHESGSGGSSTSGSGGSGSAMSSSSSSSSDMQKEKKRKKKRDDSPMGPPEKIYSRQNSPAAGGDGSAPGGVVRKFSSPSSSPKAGGSGQGLMAGVPTARPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHGSSGKPSMSTLKSAATAATILSPKGDKSSSAVGATSSGPSASSASGGAPGLVRSFASVGAPPPPPPIPPLASASGSVGSSQSLKKDKSMPGSSSSSTGSSATATVSSGGGISPASVAAAVAALKSSQQQLKSVASLSHLAAGGGLGSYAASSGAGGSAAAAVVVGAGAGAGAGASGLELSALRKGMAGGAFDDVDGSFSSNNPGSNNNSVSGNSGIGGVIGASSLGGSGSGSGNSGSGNSSSNTGNSNNAAATAAAGSGAN
Length1149
PositionMiddle
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.298
Instability index48.84
Isoelectric point9.19
Molecular weight117261.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13437
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     701.28|     135|     141|     609|     745|       1
---------------------------------------------------------------------------
  520-  608 (55.96/13.15)	......................................................W.DEEHEFKlHGV.I.....GP...GAGAAgSGPIGG.........G.....AGM..............G.GGTVTGGGnnfnqfamdTAPPSdG......NLPgggfANISNLKLDAKSRSlADafaASTSAA
  609-  745 (222.31/77.35)	AAIAGL.INLKRETDPHS.GSSGSGASTSG..SSSSSGAAKTSDHDIADKYKNIWKDKTPNLK.HCVSI.....TP.IPGDGKA.AGPTGV.........V.....PGVEVQRTGGiEiIPLNT.QAAVTGGG.........VAAPS.G......AAP....TTITITPITGKDPS.KD...SSKKSG
  746-  889 (167.27/53.20)	ATSTGVgVATKRPHESGSgGSSTSGSGGSG..SAMSSSSSSSSDMQKEKKRKK.KRDDSP.MG.PPEKIysrqnSPaAGGDGSA...PGGV.........VrkfssPS.SSPKAGG.S.....G.QGLMAGVP.........TARPS.PkhspvySSP..khNTASNSP...KSPF.GT...HSPKHG
  902- 1027 (152.08/47.74)	AATAAT.I.LSPKGDK...SSSAVGATSSGpsASSASGGAP....GLVRSFASVGAPPPP..............PP.IPPLASA.SGSVGSsqslkkdksM.....PGSSSSSTGS......SA.TATVSSGG.........GISPA.S......VAA....AVAALKS.SQQQLK.SV...ASLSHL
 1028- 1100 (103.66/30.31)	AAGGGL................GSYAASSG..AGGSAAAA............................V.....VV.GAGAGAG.AGASG.............................LELSAlRKGMAGGA.........FDDVD.G..................S.FSSNNPG.SN...NNSVSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     289.44|      92|     105|     146|     242|       2
---------------------------------------------------------------------------
  146-  242 (147.48/93.67)	EQQSSELV..ACLKSGDFADFTVQLEGlSSIYQLNAEPKVkkkAFVALQAMETDIQSLYQLHlQGHS...GDSYSLMNNSSVGLVLP..RRGGHPMKLTYFCPP
  251-  349 (141.97/77.43)	KQASGDFTidQVMRSSHGLSATVNLEG.SSANKLQTLPTV...TLVRDAQTGLEVPTYAQLN.QNNSllmPATYVLRLNKPMPVCLEslKALGLPGLDATATPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.95|      16|      18|    1111|    1126|       3
---------------------------------------------------------------------------
 1111- 1126 (28.83/13.68)	SSLGGS..GSGSGNSGSG
 1130- 1147 (22.13/ 8.24)	SNTGNSnnAAATAAAGSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13437 with Med1 domain of Kingdom Metazoa
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