<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13426

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTGDYETNALVVNNISSVSYAFYEPVASSPSTLFASSASEIEAALRKDGYLAFLDASRRGVWCFRLVTRGKSATNPADVLKFERNIESAGFAFTISEEGAFGPAQLVGHRFGPNVANTPSSSSSSASSAFDSAFRSAQSATTPSFPTPVVEQDGKTLAPPDSKPGSTASPRDAYECLLQASYSAISSCFCSRTGAVPLSSRTLLLPTTIQSECSGLPPVLASLRIYLTTTGTLIVSMSHSFANHLVAFSEIVTSQLPPLGVTVLAAPLGMFATCQPLLADTATTEGSLGQSPDTQHRFKSEKDDGTWKNLCSRLVQSRSLSLSMKAAQRWITIQRLRRKLVEQNVDGKRTPMMGHAPSMLWPASLCFCKALASLTINESDESHGLLSENDFDPLTAAKTWFSSSTERESTIDQKKRERDAIAMQDIPLIERQIQNPNTLSPLASHRPSQSGALVGAMYLTPPDGVQSVPGVTPSIDGNLSSPSNNLTTTAATEIDTVPHAPAEPYGEHWEVAETKRERVGASFESENLFGELGPDMFGDNDITEADFNFFDEQPDGNIDLTTLDLVTVPSGNPRPAPEVGLATGQTLNVKADPLHMPLASPAPTFAKPELRHARSSLIDEQRRQIALDTAQANQPSSKRPASPFNPDTVYKRIRASLDNQKAVRQNSLIYASHGSIFDKVDFGPSLSMVNSKYEGSGRFDFSMDRAKAIKPLNLDTPLTTDYLRRHSKNRKMLKELPTAYGELFVRMRGNQNPASNRPSPQPVDGSHSDADDISLMSDQDDSSYNSDEPPSPVKSSSMRRRRGDDDGDSLATSFKDLEAIDITVPHLPFELSRNSKFEIDIPLAKYFADPEPAWVQHQHSLSDDQFIMAAQILTDQVTTSTLLPSAASESSQQCGVDQRRYLSNVARNSIRELQQGLPPYFHLTTGYQLRSLIEVQDIPLLAPPTRLQPRPQGSDQMKSSNLFPVPPPRFEMRRYESRLSVLPSSISFWESLGLSPTHGAKDVRALCLFPSQEGLSDSMLVFTERLRSTYESLKLGSFSRLSTQSGDEDGLFTFDIERDVVSFGKSGSFLGPSLQSCASRVCKALSTAPGEQVNFVLFFVYTPDAAGSIVECCAAFNEIFEGYKRTLTTKKLPVVNEIALQLVPQSLVASSFSVPMPSPMELSKLALEVYDRCTIFGGTMPSPAIMLERTPPRMIDFKLNSTPSASVLHENMCLHIGYAQSIDERWITVAWTDNRGSQQMTSSYCLGRKGKSITTPLTEVIQEIWSTTRELISSWRVNWRIIVAKCGAMDTHEIELWSSLALTDHKSSINLTLVTVDTDPSLQLLPPAARIPNSATAIFYSTPGSTPQGAVVSPEQSGNAANTLRDGATVGAQTPGGDNNATDSDTDAILTDTTDQTWGVVLSHRLHTSTTLTDVNLALVSGYLVKRGGTRVEDPPIVMEVNIVHSEGKGNPRGYEPLLREMLTYYRGLGTLARARGMVDKDVDVRPWHIAAAEKGVRALYMLM
Length1505
PositionKinase
OrganismRosellinia necatrix (White root-rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Xylariaceae> Rosellinia.
Aromaticity0.07
Grand average of hydropathy-0.313
Instability index52.24
Isoelectric point5.49
Molecular weight164151.82
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13426
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     420.52|     117|     181|     462|     578|       1
---------------------------------------------------------------------------
  462-  518 (72.08/31.52)	...............................................................................................P..PDGVQSVPGVTPSIDGNLSSPSNNLTTTAATEI.DTVPHAPAEPYGEHWEVAETKRE
  519-  578 (74.19/32.66)	RVGASFESE......NL.FGELGPDMFGDNDITEADFNFFDEQPDGNIDL.TTLDLVTVPSGN.PRPAP......................................................................................
  587-  695 (151.15/74.35)	TLNVKADPL......HMpLASPAP.TFAKPELRHARSSLIDEQRR.QIAL.DTAQ.ANQPS.S.KRPAS..........................PfnPDTVYK..RIRASLDNQKAVRQNSLIYASHGSIfDKV......DFGPSLSMVNSKYE
  699-  831 (123.10/59.16)	RFDFSMDRAkaikplNL.DTPLTTDYLRRH...SKNRKMLKELPTAYGELfVRMRGNQNPASNrPSPQPvdgshsdaddislmsdqddssynsdeP..PSPVKSSSMRRRRGDDDGDSLATSFKDLEAIDI..TVPHLPFE..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     469.29|     149|     176|    1110|    1265|       2
---------------------------------------------------------------------------
 1110- 1265 (238.32/169.09)	IVECCAAFN..EI.......FEGYKRTLTTKKLPVVNEIALQLVPQS..LVASSFSVPMPSPMELSKLALEVYDRCTIFGGTMPSPAIMLERTPPRmiDFKLNSTPSASVLHENMCLHIGYAQSiDERWITVAWTDNrgSQQMTSSYCLGRKGKSITTPltEVIQEI
 1283- 1442 (230.97/143.40)	IVAKCGAMDthEIelwsslaLTDHKSSINLTLVTVDTDPSLQLLPPAarIPNSATAIFYSTPGSTPQGAVVSPEQSGNAANTLRDGATVGAQTPGG..DNNATDSDTDAILTDTTDQTWGVVLS.HRLHTSTTLTDV..NLALVSGYLVKRGGTRVEDP..PIVMEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     281.42|      74|     190|      92|     181|       3
---------------------------------------------------------------------------
   21-   91 (62.85/22.92)	YAF..YEPVASSPSTL....FAS.SASEIEAALRKDGYLAFLDAsrrgvwcFRlvtRGKSATNPAdvlkFERN.IE...SAG...........
   92-  165 (128.29/68.78)	FAFTISEEGAFGPAQLVGHRFGP.NVANTPSSSSSSASSAFDSA.......FR...SAQSATTPS....FPTPVVE...QDGKTLAPPDS.KP
  375-  448 (90.27/47.59)	..LTINESDE.SHGLLSENDFDPlTAAKTWFSSSTERESTIDQK.......KR...ERDAIAMQD....I..PLIErqiQNPNTLSPLAShRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     208.18|      73|     700|     288|     374|       4
---------------------------------------------------------------------------
  288-  374 (110.87/101.64)	SLGQSPdtQHrfkSEKDdgtWKNLCsrLVQSR.SLSLSMKA.AQRW.ITIQRLR....RKLVEQ..NVDG......KRTPM.MGHAPSMLWPaSLCFCkalAS
  992- 1080 (97.32/56.56)	SLGLSP..TH...GAKD...VRALC..LFPSQeGLSDSMLVfTERLrSTYESLKlgsfSRLSTQsgDEDGlftfdiERDVVsFGKSGSFLGP.SLQSC...AS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13426 with Med13 domain of Kingdom Fungi
Unable to open file!