<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13421

Description Putative transcription mediator subunit Med12
SequenceMTSRSSLASSQRQPQRTLSASGLSQRPATQRSLSQQYLPQSPKRRSDGFNNEQGADGGDGAQNRYGTTPRRGGSKLKLELANDGIVHTGFVESPQNPDPLSANKVFTPSRVMSMADAPDLGDMSPQTSRCQTADGDSAPLPMPPRRTRFVAPSKRFQPSPVNAPAKKDARTKPFVLDVPPDAPRYSTMGRQEPCGRTRKNEGSTHRDTDAFSGYADFYPWRGGHPEDQFSDNIIRMGYFDKPPAPQTQELTSAKPTLFPALKHKTGLQTLSNIFTGILNQRRHIGQITSPSTFKPPPRVTLTDTKREAWLKDLANSTIPLRRLSRTIPHGIRGRVLLDQCLNKNVPTDRAVWLAKCVGANEIRAFKRKGVNNTFVMGGEVKWIRDWTLCVEQFVEAIISAFTEEDWKAKVTYAIRLAAHLYAEHLLDRDHYMEWLIINLESSSEAKLPMWLLLIQIYWKDMLKLRRHGRRLVTAMLNHHCSIYDSPDRDILLPLSIQLGSLIESLISASPDSFVHPDTWSKRRDSLKSFLSSRRESAYTAFDTIDARTDLLTSSNVRTRPAIRSTLVALLDNMLRLPFKDDIPGQIRKATKNTPVLIRTTLEWCTSLYRFGAAKVYVAVTILRSLSDSNTDLTNEILCFLNADALQEPPRKHSIYHLISELVRSGHFSVPQYIQWLIATGGLHEPFEAQPDGPCSRRLLVEIPAHAFNDSMRSVRASLLRRASFSVEDEASDIAMAIRCVKHALSVPLDDNDLMLQKQPMSVRKLARRIGLSSRSLKAEVSSWLANDFAGSVFQQPQADKAHPMPLERSLDTIRTLLEAAQDFNMLDTTLAYMTNSSNVEALSYCVNTLSLHLPVFFAMGSAKPLFNSFYDRLRSISLEQGVGARPLLASLANLAPRLPGFESMASQLRNELLIADRSNAVDASSPLSDNMATQLQDDETELGEQIEKLANYTSADKLTMERLFHTIVTKLVSCWAKGDERQRPYSILLSRLRVFDTQYFDTLMKDWVQHIRKLTKRAPIAQMYPLLVSSGCLSLTTLLATALRSQTQVALNQPNAVGSASTYMQEILQMLMKPLVPDHILALDDCYRFRIIQEQARLEYAREVMLLVRGSLAEYAASRNQQPPRPQPLDDEKVKSYLFELLRDLILIDPQAASETLSLKSPNAKLATLIEALTTRLLVPHCGSVQKTFEQVLELANEFTLPFCQVKLSLNLAIHDPSTPEGAEGLRAQFEQLSIAMDNAIEADNIMWTGMLSYLSSDITLHLKNRAEARFLDLFPSLKSLPFDENVSKGDVHMAENLLTVVDSVLRGASTSKPSSFSSGIADRLTDLWEILGSTSQESATLKSSVLTHWLPLLLSYLALQAYQSSTAVDLSKLPGSDVRARVLVILAGIVLELDKYPTSRLGPRVFDIALIIADNLPEESRLQCVRAVKDYTADPRVTYLFSLSPDPAENLMLAHREKGPPSHHERKMMAMNLGLGMPQEKLTPFAFRRWEILNEPTPNIGENDTSLSLTLFDARKI
Length1518
PositionKinase
OrganismRosellinia necatrix (White root-rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Xylariaceae> Rosellinia.
Aromaticity0.07
Grand average of hydropathy-0.287
Instability index50.54
Isoelectric point8.68
Molecular weight169877.50
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13421
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     475.50|     163|     240|     388|     574|       1
---------------------------------------------------------------------------
  388-  574 (240.52/185.99)	LCveqFVEAiiSAFTEEDWKAKVtYaiRLAAHLYAEHLLDRDHYMEWLII..NLESSSEAKL..P.MWLLLIQI...YWKDMLklrrhgRRLVTAMLNHHCSIYDSPDRDILL.......PLSIQLGSlIESLISASPDS...FVHPDTWSKRrdSLKSFLSS..RRESAYTAFDTIDArtDlltssNVRTRPAIRS..TLVALLD.....NML
  637-  826 (234.98/131.18)	LC...FLNA..DALQEPPRKHSI.Y..HLISELVRSGHFSVPQYIQWLIAtgGLHEPFEAQPdgPcSRRLLVEIpahAFNDSM......RSVRASLLRRASFSVEDEASDIAMaircvkhALSVPLDD.NDLMLQKQPMSvrkLARRIGLSSR..SLKAEVSSwlANDFAGSVFQQPQA..D.....KAHPMPLERSldTIRTLLEaaqdfNML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     699.14|     240|     320|     827|    1104|       2
---------------------------------------------------------------------------
  827- 1104 (349.98/335.85)	DTTLAYMT...NSSNVEaLSYCVNTLSLHLPVFFAmGSAKPLF.......NSFYDRLRSISLEqgvgarpllASLANLAPRLP.GFESMASQLrNELLIAdRSNAVDASSPLSDNMATQLQDDET.ELGEQIEK..LANYTSADKLTM............ERLFhTIVTKLVscwaKGDERQRPYSillsrlrvFDTQYFDTLMKDW.....VQHIRKLTKRAPIAQMYPLLVSSgcLSLttllaTALRSQTQVALNQ.PNAVGSAS..TYMQEILQMLMK.......PLVPDHILALDDCyrfriIQEQARLEYAREV
 1149- 1429 (349.16/240.21)	DPQAASETlslKSPNAK.LATLIEALTTRLLVPHC.GSVQKTFeqvlelaNEFTLPFCQVKLS.........LNLAIHDPSTPeGAEGLRAQF.EQLSIA.MDNAIEADNIMWTGMLSYLSSDITlHLKNRAEArfLDLFPSLKSLPFdenvskgdvhmaENLL.TVVDSVL....RGASTSKPSS........FSSGIADRLTDLWeilgsTSQESATLKSSVLTHWLPLLLSY..LAL.....QAYQSSTAVDLSKlPGSDVRARvlVILAGIVLELDKyptsrlgPRVFDIALIIADN.....LPEESRLQCVRAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.90|      16|      18|     108|     125|       3
---------------------------------------------------------------------------
  109-  125 (25.35/19.84)	SRVMSM.ADAPDLgDMSP
  128-  144 (27.55/10.76)	SRCQTAdGDSAPL.PMPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.90|      23|     337|     235|     274|       5
---------------------------------------------------------------------------
  240-  262 (41.03/47.47)	DKPPAPQTQELTSAKPTLFPALK
 1121- 1143 (41.87/12.02)	QQPPRPQPLDDEKVKSYLFELLR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13421 with Med12 domain of Kingdom Fungi
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