Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNKQIDACFDRVEKALGTLIDSIAKYNPSTNQARELGNADAELTSGLKDLQTHQSNYQRIQDLRASTARYDAQIRDTLRLLANTRRELVHASATAFPDGPSHEIRYDELLSYARRISKTTIPPVGAANAITAATAAADAAAASASAAETTAATTPNGTSTNANTPQPQGPSDPTPAAMTTTTTTTGLPEPLATFLNPHSAYTFVPWPSEEQVRRGAVASLAYMAEQGIEAEGYDPEAERARRDREDEDRRLLLAEDRARADRDDRERRRREEQQQQQQQQQRAARRDRERDEAASASAATATATDAADSWRRASVSVGAGAAPPGGAAAAGAGAPAQPQPQPKAQFQFMGDDDDDDDD |
Length | 358 |
Position | Middle |
Organism | Rosellinia necatrix (White root-rot fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Xylariaceae> Rosellinia. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.843 |
Instability index | 53.23 |
Isoelectric point | 4.90 |
Molecular weight | 38518.33 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP13420 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.07| 13| 24| 92| 104| 1 --------------------------------------------------------------------------- 92- 104 (24.52/15.47) SATAFPD.GPSHEI 117- 130 (18.55/ 9.81) SKTTIPPvGAANAI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 124.58| 40| 170| 132| 177| 2 --------------------------------------------------------------------------- 132- 173 (65.70/31.51) AATAAADAAAAS...ASAAETTAATTPNGTST.NANTP.QPQgpSDP 298- 342 (58.88/17.89) AATATATDAADSwrrASVSVGAGAAPPGGAAAaGAGAPaQPQ..PQP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.63| 22| 25| 241| 265| 3 --------------------------------------------------------------------------- 241- 265 (33.33/22.88) RRDREDEDRRlllAEDRARADRDDR 267- 288 (39.30/20.24) RRRREEQQQQ...QQQQQRAARRDR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AQPQPQPKAQFQFMGDDDD 2) SWRRASVSVGAG | 336 309 | 354 320 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab