<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13417

Description Mediator complex subunit 14 (Fragment)
SequenceXINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPASYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGALDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFVSITWHHLSVLSF
Length498
PositionTail
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.07
Grand average of hydropathy-0.192
Instability index69.35
Isoelectric point9.60
Molecular weight53676.17
Publications
PubMed=15057822
PubMed=22673903

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	ISO:RGD
nucleus	GO:0005634	ISO:RGD

GO - Biological Function
transcription coactivator activity	GO:0003713	ISO:RGD
transcription coregulator activity	GO:0003712	ISO:RGD

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	ISO:RGD
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISO:RGD
positive regulation of transcription, DNA-templated	GO:0045893	ISO:RGD
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
stem cell population maintenance	GO:0019827	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13417
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     179.35|      36|      36|     140|     175|       2
---------------------------------------------------------------------------
  104-  140 (36.51/10.71)	..P.PSPIGGDMMDSlISQL..QPPQQ..QPFPKQPgtSGAypL
  141-  176 (68.31/26.49)	TSP.PASYHSTVNQS.PSMMHTQSPGN..LHAASSP..SGA..L
  177-  209 (47.43/16.13)	RAPsPASF...VPTP.PPSSHGISIGP..GASFASP..HGA...
  230-  254 (27.10/ 6.04)	GSP.QVSGPSPATRL.PGM....SPANpsLH.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.49|      49|     162|     280|     339|       3
---------------------------------------------------------------------------
  280-  339 (73.88/46.27)	PRKLPQRSWaaSIPTILThsalnilLLPSPTPGLVPGLAGSYLCSPLERFLGsvIMRRHL
  445-  493 (90.61/37.97)	PDQATQLKW..NVQFCLT.......IPPSAPPIAPPGTPAVVLKSKMLFFVS..ITWHHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.52|      25|     395|      16|      46|       4
---------------------------------------------------------------------------
   16-   46 (33.64/42.68)	RTNTAYqCFSILPQSSTHIrlaFRNmyCIDI
  414-  438 (44.88/30.29)	KANTLI.AFTKLLGAPTHI...LRD..CVHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.28|      16|      40|     354|     374|       5
---------------------------------------------------------------------------
  354-  374 (23.97/29.55)	NEPGVI..MFKTdalkcRVALSP
  395-  412 (25.31/16.09)	DELQVLekFFET.....RVAGPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13417 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPASYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGALDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWA
90
289










Molecular Recognition Features






MoRF SequenceStartStop




NANANA