<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13416

Description Mediator complex subunit 14
SequenceMAPVQLENHQLIPPGGGGGSGGGGGSSSGSASVPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRSFNANENSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYATHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVSTADRDDSPAMALLLQQFKDNIQDLMSCTNTGKQTRTGTKHKLSDDSCPVECKKAKRSGETCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGEIFTHCFCLCV
Length757
PositionTail
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.06
Grand average of hydropathy-0.122
Instability index43.04
Isoelectric point7.30
Molecular weight84380.74
Publications
PubMed=15057822

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	ISO:RGD
nucleus	GO:0005634	ISO:RGD
GO - Biological Function
transcription coactivator activity	GO:0003713	ISO:RGD
transcription coregulator activity	GO:0003712	ISO:RGD
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	ISO:RGD
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISO:RGD
positive regulation of transcription, DNA-templated	GO:0045893	ISO:RGD
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
stem cell population maintenance	GO:0019827	ISO:RGD

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13416
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      51.82|      11|      31|     141|     151|       1
---------------------------------------------------------------------------
  141-  151 (16.18/ 9.69)	RLASLARDALV
  174-  184 (18.58/12.36)	RLPTCIRDKII
  200-  210 (17.06/10.67)	QLNQILRHRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.44|      29|      33|     215|     246|       2
---------------------------------------------------------------------------
  215-  246 (44.06/30.71)	P..P.QLANLTVAngrVKFRVEGEFEATLTVMGDD
  247-  278 (39.38/20.19)	PevPwRLLKLEIL...VEDKETGDGRALVHSMQID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.97|      21|     440|     284|     307|       3
---------------------------------------------------------------------------
  284-  307 (33.85/34.55)	VQSRLFADeKPLQ........DMYNclHCFCL
  727-  755 (35.12/22.36)	VAELVFAN.CPLNgtstreqgEIFT..HCFCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.28|      52|     149|     314|     391|       5
---------------------------------------------------------------------------
  314-  365 (91.55/101.03)	LHSQ..TLMLIRERWGDLVQVERYHAGKCLSLSVWNQQV...LGRKTGTASV.HKVTI
  464-  521 (78.73/41.96)	LHSGmfQLMLYGLDQATLEDMEKSLNDDMKRIIPWIQQLkfwLGQQRCKQSIkHLPTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.05|      17|      28|      13|      29|       7
---------------------------------------------------------------------------
   13-   29 (33.33/21.38)	PPGGGGGSGGGGGSSSG
   38-   54 (28.72/17.44)	PPGAAVAAAAAAAASPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.39|      11|      28|     366|     376|       8
---------------------------------------------------------------------------
  366-  376 (19.13/13.26)	KIDENDVSKPL
  397-  407 (18.26/12.32)	KIDHLSIEKLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13416 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VQLENHQLIPPGGGGGSGGGGGSSSGSASVPAPP
4
37










Molecular Recognition Features






MoRF SequenceStartStop




NANANA