<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13398

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGAVVRRAAEESYLALRELVEKSQAEAEGKGLGAGANGGWQRSDTEKKIDLLKFITRTRQRMLRLHVLAKWCQQVPLVHYCQQLGSTLHSHETCFTQTADSLFYMHECLQQARAPMFDVPSAIEVMLTGGYQRLPRCIEEIGSQNKLSPDEEKCALRKLDASVRYKVLVTPRPKEVSNVSVTDGIAVFRVDGEFKVLLTLGYRGNVDLWRILHMELLVGEKKGPIKLDQSRRFALGDDIERRMAASENPFAVLYAILHEFCISLAMDTIIRQANVLRQGRWKDAIRSELISDSATGQTGNTPLMQLVQDGEFDASGFKIPGLKVNYWLDEKSTGTTEPDSSPFIKIEAGLDMQIKCQHSSFILDPFTDKEANLSLDLSCIDVEQLILRAIACNRHTRLLNIQRQLCKNVQISQSPKDVVLTRDVAAAKDPTKNAEKKGFSDCFGNEVLQVRAYGQAYVSLGINIRSGRFLLQSPENILPRAAIMDCEEALNKGSTSATEVFSSLRTRSILHLFAASGSFFGLKVYQQSQGTLKIPKTILHGSDLMVMGFPHCANAYYLLMQLDKDFRPVFHLLETQCDANDKTNANGDAKEAIRFNKINIGQMQILKNETNANPFDMKLQALQSLVDPADMMESDLPVQNGIETLPLLPACSPSFSSIVDEVFEYERGSTAAQNHSLSVDIQGINARVVSPMHDGSLSHTQANNIAKIHPSGSLNSYFPSNFRYLQGVNKSLHLVPSSNNNSSQIPAQSSHSGNLGNAMPGHLVGSSTITGGLEKSITAGSDGASRKRSLSDFLPSIPSLRGLQASEPRKRRKKSESVQNILPLQAHSSNLQSRVSLTYGDVLAERNNCVPATIYASVLLHVIRHCSLCIKHAQLTAQMDSLAIPYVEEVGLRTPSSNLWLRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFRELWELNGGSTTTQWGVGIRIANSSEMDSHISFDSNGVVLTYNTVEADSVQKLVSDLRRLSNARSFARGMRRLIGVKLDDKLDDNQLSMEVKSQSVNKGNSDAADKLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHIVVEWEIDKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYSSMPKQPNILTQGPLANGSSSSTIHHAPVPQNAAAAQLGSHNLHAAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNFMNATQASGHLNNNAGAPQTAPSANRLSATPGVSMSRPTSGVANHVAASLSRAGNAMLASSALASGISGASVRLTAGAGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELAAAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLITWKKGLSPVNGDIATAQRARIELCLENHSGSAAADNTENSTLAKTGGAAWLPYCVSVKLRYSFGDNNHIAFLAMNGSHGGRACWLQFEEWERCKQKVSRAVETVNGSGVAGEVGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1693
PositionTail
OrganismSorghum bicolor (Sorghum) (Sorghum vulgare)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Sorghinae> Sorghum.
Aromaticity0.06
Grand average of hydropathy-0.180
Instability index48.89
Isoelectric point8.43
Molecular weight184912.02
Publications
PubMed=19189423
PubMed=29161754

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13398
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     245.33|      79|     115|    1126|    1216|       1
---------------------------------------------------------------------------
 1126- 1213 (115.25/82.51)	IRLTAGPLLALGGAIRPARMPvTVsSGYSSMPK.QPNILTQgpLANGSSSstihHAPVPQNAAAAQlGSHNLHAAAMLSA..AGR..GGPGLV
 1244- 1327 (130.08/64.92)	MRCFAGDQVWLQPATPPKGGP.SV.GGSLPCPQfRPFIMEH..VAQGLNA....LEPNFMNATQAS.GHLNNNAGAPQTApsANRlsATPGVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     277.10|      94|     115|     202|     308|       3
---------------------------------------------------------------------------
  202-  308 (142.74/121.73)	DGEFKvllTLGYR..G.NVDLWrilhmellVGEKK.GPIKLDQSR..RFALGDDIERRMAASE...NPFAVLYAILH.EF.CISLAmDTIIRQANVLRQGRWKDaIRSELISDSATGQ
  320-  424 (134.36/85.43)	DGEFD...ASGFKipGlKVNYW........LDEKStGTTEPDSSPfiKIEAGLDMQIKCQHSSfilDPFTDKEANLSlDLsCIDVE.QLILRAIACNRHTRLLN.IQRQLCKNVQISQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.70|      17|      28|     783|     806|       4
---------------------------------------------------------------------------
  783-  806 (23.43/36.71)	GLEKSitagsdgASRKR.....SLSDFLP
  813-  834 (25.26/17.14)	GLQAS.......EPRKRrkkseSVQNILP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.90|      13|      15|    1340|    1352|       5
---------------------------------------------------------------------------
 1340- 1352 (20.77/ 9.74)	AASLSRAGNAMLA
 1357- 1369 (20.13/ 9.22)	ASGISGASVRLTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.50|      10|      26|    1404|    1413|       9
---------------------------------------------------------------------------
 1404- 1413 (16.81/11.95)	LKKVLRGILK
 1428- 1437 (16.69/11.79)	LKEILGSILK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13398 with Med14 domain of Kingdom Viridiplantae
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