<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13392

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEGLPAVEPVELRDLVARCVDKSYEGFRALAHGLPGVNKADERREQTLKHLADTRSLFEKLLVLTRWSVQSPLAAQCAELLKTAKLFQDQLNESNDRLFFLHADLNRAKERNYDLPTAVDVLYGGSYTRLPKIINYAMHPKEMPEVDEDKAIQEMEDIIRFRLIEEEIPSTFTRIDVEGGFVVAQVDGEFEIVFTLNGKESDSLWRLVAINTVLTDLTAQEKYKPLASTNTLRIIKANAPTELHYMHMRNLVQKCMNKSDKPFVAACDVMRDFCCSLSLQILVAQGQLLTDARWKGSNVEFIYHADKQVLDICYWSAFCRPAVLSTEAVQLAAEMADKFKKPEAEALPDYPASSLCVRLYSDAQHHDLLSVQLYPPPAPELRQALSDALVVPRNMYGLSAEAFLLGAMRMHVASTLFCLERHLVLGTGSTTPVHLTTGEAVTIVRTERSLHISRHDSGGLPQYELEISFDIRTGLFAAACVAASKSPIVDGVVKQLEALLQRTCKAQLPPKGTTGTGFALAFEVAAKAAAAPSVAEAVAACLREMLAYEISEVASTFANIEVHRHVSVNWDRYIAFRKQQGNNVDALSISPNALFFQIVRNKESCGYLVVEIDREAEYESSTDVHYIENEDDWVRVPAFSLLQLSSSAGAPSAVQFFQRFPAFRKDALAPLMPPPTKKLKPARPTPPLAPLFLHVVSLCHERIQLQHYVNFAKRRRVRIRYAGQGGTETAGLQTGEQIVSFPFPERVSSAPMQIRAVHGHLRKCGGFEMCVQLAAPPFRFVIPSDFAALVNHGDHHALPNGHLIFRYPPTTKLQPDNPLETFIADLLMNVKPMCEFGVKLEKTLGSLGRYGPEAADVRDHFYVERADPFSIVLACRTNNPKRCVAAGSTPDDLITYRIVVQFKPKGGFILTSSHRGEHPLLQYIQAALNVHNDSAQLLEALERTTIPLAILSSVVSSQVISAKCYRHDAPAEKEPSGFGGKKGGGKGMRLGYKGKLPGEEKGYYAEKTYGGDDRAFVPADLLLIPRSQNHIRLTYADRCGIDVLFMENESVTLKSAPCGARVPSCSGDGGLVVSHAAFGENLRSTIFPEMASL
Length1093
PositionTail
OrganismAchlya hypogyna
KingdomOomycetes
LineageEukaryota> Sar> Stramenopiles> Oomycota> Saprolegniales> Saprolegniaceae> Achlya.
Aromaticity0.08
Grand average of hydropathy-0.133
Instability index43.80
Isoelectric point6.57
Molecular weight120959.40
Publications
PubMed=25527045

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13392
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     482.00|     137|     272|     637|     784|       1
---------------------------------------------------------------------------
  363-  488 (128.09/61.00)	..........................AQHHDLLSvQLYPPPAPE.LRQ..ALSDALVVPRNMYGLSaeaflLGAMRMHVASTL.FCLERHLVL...GTGSTTPVHLT.......TGEA.VTIV.RTERslhISrhdsgGLP.QYElEISFDIR.TGLFaAACVAASKSPI
  498-  625 (126.29/59.75)	ALLQRTCKAQLPpkgtTGTGFALAFEVAAKAAAA.PSVAEAVAAcLREmlAYEISEVASTFANIEV.....HRHVSVNWDRYIAFRKQQGNNVD.ALSISPNALFFQivrnkesCGYLVVEIDrEAEY...ES.....STDVH...........................
  640-  778 (227.62/138.72)	SLLQLSSSAGAP....SAVQFFQRFPAFRKDALA.PLMPPPTKK.LKP..ARPTPPLAPLFLHVVS.....LCHERIQLQHYVNFAKRRRVRIRyAGQGGTETAGLQ.......TGEQIVSFP.FPER...VS.....SAPMQIR.AVHGHLRkCGGF.EMCVQLAAPPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     250.37|      77|     162|     832|     917|       2
---------------------------------------------------------------------------
  832-  917 (120.93/121.32)	PMCEFGVKLEKTLGSLGR.YGPeaADV......RDHFYVERADPFSIVLACRTNnpkRCVAAGSTPddlITYRiVVQFKPKGGFILTSSHRGE
  997- 1080 (129.44/98.42)	PGEEKGYYAEKTYGGDDRaFVP..ADLlliprsQNHIRLTYADRCGIDVLFMEN...ESVTLKSAP...CGAR.VPSCSGDGGLVVSHAAFGE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.53|      24|     230|       6|      29|       3
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    6-   29 (43.65/27.34)	AVEPVEL.....RDLVARCVDKSYEGFRA
  237-  265 (38.88/23.61)	ANAPTELhymhmRNLVQKCMNKSDKPFVA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13392 with Med14 domain of Kingdom Oomycetes
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