<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13379

Description Mediator of RNA polymerase II transcription subunit 12 protein
SequenceMAAVAPWLYEKRALKKPRLGPPDVYPQDPKQKEDEITATNVKQGYASNPIQDECGTARNASITAAKFGAFFSSILAKKQELNTLTDSGRKKQQINVKECFWPVTAKSKNVFENWFKDLAGSKPLTSLAKKVPIFNKKEEIFTILYDFQVPMVRAAWFLKMASVYTAAISEAKMKKRQLPDPSQDWTHSLCKFMKDILIRMVEQPSASVPSTQSTTPPQQSPPPPTQIDAHNQSLTKHWQYLCQLASHCFQDGLLDQQDFMSWLLELIERAKGPDDPTLRITLPLVLQYTTDFTKNEILSRRLAYQCSKKIAHLVADYTPKESPTARKEGSPVDELSPLAQAFVEILSCPYHRTTFLTMCSIVQIITLDCPTSLVFNQTIPEGLSKDEVSSKRMLNGSPLDILPCSPSQLPIIPDDPEARKEIREAEEHIVQRSRSCEMRWSCERWQSQSTATGAVMTKVLATLDSLDRHSFDKIETNNSFETLYTKIFADWPTTTTANNEVDGKSLAVQELEPFVKLVCEWAVTTKRRGEHRALIVAKLLERKQAEIQGPSGGKEDDEDSFVTQPPAFQELFVRFLDTQAPILDDKVTESRLAFANLVLLFSELIRWEVFSHDLYMCTLISRGYFANPPVASLPVAAIASVPPPPGASSSRSVNTPPGPSSLGFLDPSHGPSPGIGGVQSGPHSNQLPLFSPGGQVPPVVKQEPHGWSGNDAQTDYDDTRLDADLDKLLQRIKEEQQSDQQPELFSDSVGSDREDGKEGTPHMSSKQLRHLQYTTHFPLPAADLDGAGGGASHECNQRHVLLYGVGRTRDEARHVVKKVAKDAGKLFAKKACMDVSEGGKVRKSAKESVSLDAVSQRFQALPYNDQHTVAASVGAQLLEIINGFATGSSNYLPLAEHISFLLSLMEMAQNVNGLLELCLHILKELPDVEAMLVQKSSPVAGVYVPTVTLNVVGLLYRYHCCLLVSPEQTLAVCDALCRLVANLEDTSKCSSAQRCILCYIYDLYTACYFLRQKYADSFLGTLVAKVKQNFYVNQTPQGVNFMWKTSQFAELFANPRAARPGEPSAMVNAAAAQSAVLQQLNENPSARYSFVCSAIAAVASCTDLERLNDIALLCAEMTAGCQQLPGEWLGVLKALCCSSNHACGFVDVLQVVDISDVSTHDHVAVLSSMLVARRCFSLQDFVVHVAIPSLLNASPVSGATHIEAEPGARMSCHLLLRLFRTVEATGGTVPVGRFLIKAACDRHLLLAAHNSMRVEPVLAVLKAILLLGETGSDSSGLNDTTPQLLEDTDALSMASQAPLKDFSKFALAHICSQQWVHERCLRDPDLLCTNDLLLDPMLTPTQAESLLSLICYPQSSFSTDGGKRRVESNPDHRQRLVKILSNLDQWSLRVSWLQLQVMHMQCQQSAEVPHWLDNVARASIDVFQLCDAASGSQQPSGGGNTTTHSNDDKKPSISQQGQHGHGHSPSKRSSLQQDHMEFIWFVAPLVSKLPGVQGKILRQAGHTLENGNWTAYAAKKDTKACKGAALLNHQPFLSLILSCLKGQDEHRESLLKSLNAQLTQCLSTTRDDKTLLDDLKARKSFHEALLLRLSLVGGMFDMIQRSTTYTMDWALIFLELITTGLVDSHSHRELFYTVLDMLATLIHTSYEGTFSEDSRRQYFALIKKLKKEVNESSQNSDVKLVLQLLPFPKRQCTVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVAEKQNISPWDLLEGHKNPAPLMWKWFGAVRVERKPTRLDETYRSLLWHTHSALVKSSDYFLDPPQLPQEDLDPPPSTTPTPPVAPTGAPAAPMAPSIPPTPPGNNGPTPAPPHTAPISTGQPQNQQPNIIAPGNYGGPPTHIMGGPIPGGPQPGNMGPPGIMGQPAPGGPHGPPHGSHAMMDIKPVIGHHTGHPMGQGNSMGPAQPGPGPQTGPMVGQMPGHVNQMGPGQLPGPQGGMPPHMGPGHIGQGPMGPGGHMGAQGNPMGQMPPGGPMAPMNMGGPAGPMNMGQMPPGGPMVPGGPGGQMQGIPPQGIPPSMLGPHQNMMSGPAGHMGLAGGNSPTRGARKPRQPRRPRKPKNNQQQAVAQSQPAATSIQAPRGQMAYGDIYGGPGGPGGPGGGGQQGQQGPQQQQGNWGGYGGGPQQQPQPPQQQPGQPQPGPTGYYQPPGGAQMGPQGPQGPGPQMGQQRFERQPAKAALSSMLRQRTQPPSQGMQNQAGGPTGYPGQPNPGQQYGGNMQPQPGPPDMMSNPRMPLMAPQQRGMAPQRLPNPNQFAQGPGGQFGQQQGPSPAQFADQGIRARGPAPPNMMAGPGGFASQGQGGGGYGGGVGGYVGAGAGGHPQAGGGMQQRPQYPLSNSGQPAGGMGPQQQPGMGGQGGMMGAGFQQQGPQMARGQNPNQFINPQQQRGQPPMQSGMPPQRPPYPGQGPY
Length2433
PositionKinase
OrganismTropilaelaps mercedesae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Acari> Parasitiformes> Mesostigmata> Gamasina> Dermanyssoidea> Laelapidae> Tropilaelaps.
Aromaticity0.06
Grand average of hydropathy-0.436
Instability index52.30
Isoelectric point7.65
Molecular weight262722.88
Publications
PubMed=28327890

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13379
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     962.98|      80|      80|    1919|    1998|       1
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  641-  694 (53.86/ 8.46)	...............................VPPPPGASSSRSV.NT.P.PG.PSslGFL.DP...S.H..GPSpGI...GGVQ....S.GP........H.SN.Q.L.PL.FSPGG.
 1824- 1902 (115.67/26.10)	PT.PPGNN.GPT...P...AP.PHTA..PIsTGQ.PQ..NQ.QP.NI.IaPG.NY..GGP.PT...HiM..G.G.PI...PGGPqpgnM.GPPGIMGqpAP.GG.P.H.G...PPHGS
 1919- 1998 (184.44/45.72)	PM.GQGNSMGPAQ..P...GPGPQTG..PM.VGQMPGHVNQMGP.GQ.L.PG.PQ..GGM.PP...H.M..GPG.HI...GQGP....M.GPGGHMG..AQ.GN.P.M.GQ.MPPGGP
 2001- 2076 (96.15/20.53)	PM.NMG...GPAG..PmnmGQMPPGG..PM.V...PG.....GPgGQ.M.QGiPP..QGI.PP...S.M.lGP..H.....QNM....MsGPAGHMG.lAG.GNsP.TrGA.RKPRQP
 2082- 2143 (97.11/20.80)	PKnNQQQAVAQSQ..P...AATSIQA..PR..GQ.......MAY.GD.I.YG...................GPG.GP...G.GP......GGGGQQG..QQ.GP.Q.Q.QQ.GNWGGY
 2144- 2202 (92.37/19.45)	G...................GGPQQQ..P....QPP....QQQP.GQpQ.PG.PT..GYYqPPggaQ.M..GP........QGP....Q.GPGPQMG..QQ....R.F.ER.QPAKAA
 2205- 2265 (102.90/22.45)	SM.LRQRTQPPSQ......GMQNQAG..GP.TG.YPGQPN...P.GQ.Q.YG.....GNM.QP...Q.P..GPP.DM.......................M.SN.PrM.PL.MAPQQR
 2266- 2348 (103.60/22.65)	GM.APQRLPNPNQfaQ...GPGGQFG..QQ.QGPSPAQFADQGI..R.A.RG.P.....A.PP...N.MmaGPG.GFasqGQGG....G.GYGGGVG..GYvGA.G.A.GG.HPQAG.
 2349- 2393 (67.44/12.34)	....................GGMQQR..P....QYP....LSNS.GQ......PA..GGM.GP...Q.Q..QPG.....................MG..GQ.GG.M.M.GAgFQQQGP
 2394- 2432 (49.44/ 7.20)	QM.ARGQN..PNQ.fI...NPQQQRGqpPM........................Q..SGM.PP...Q.R...PP.YP...GQGP..................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.52|      12|      15|    1788|    1799|       2
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 1788- 1799 (24.37/10.43)	PPQLPQEDLDPP
 1806- 1817 (23.15/ 9.42)	PPVAPTGAPAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.65|      53|      80|    1532|    1589|       3
---------------------------------------------------------------------------
 1532- 1589 (74.38/66.46)	FLSLILSCLKGQDEHRESLLKSLnaQLTQCLSTTRDDKTLLDDlkARKSFHeALLLRL
 1613- 1665 (90.27/61.63)	FLELITTGLVDSHSHRELFYTVL..DMLATLIHTSYEGTFSED..SRRQYF.ALIKKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.96|      16|    1129|     182|     197|      10
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  182-  197 (31.91/22.56)	SQDWTHSLCKFMKDIL
 1312- 1327 (32.05/22.69)	SQQWVHERCLRDPDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.48|      11|      15|    1128|    1138|      15
---------------------------------------------------------------------------
 1128- 1138 (21.07/14.99)	WLGVLKALCCS
 1145- 1155 (17.42/10.97)	FVDVLQVVDIS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13379 with Med12 domain of Kingdom Metazoa
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