<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13373

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMTIITLLSDPKKNPNAVVSGPVSRPNGPAGVGHGGQDPMMALRTMTNPHHQQQGHSPMSGGSIGANQMGSGPIGAPADLMASQSSTPQLPNGAGGLNPMAMQIPRPIVINQGNPMVMGQQIGATVRTPEQSGVGGVGPPVQGMMTVGVPPEVKLRPQMVPQQPQNLLATNQGAVQSPMGASVTNQIGCSSPTGFAHSPSTVGVGGQGGYLRGGPLVARSPGSALNTPVGSVVSPASQHSQQQQHAAGHHVGPGTSSAPGSTEEQAYLDKLKLLSKYIEPLRRMISRIDKDEDRQKDLGRMRSLLDILSDNNRRCSMDVLLKCEGVLEKLDLGQAIPRDHIGHVPSVTSMTRLQNDNIWQPLLDAINANIKSPMFNHTMQRVFGPPITMLTGAAYLRSASSPPTSPAAKRRRGAVDDVAEIPDVLQGEIAHLDQRFKVQLDPVQQSGCRTVNLICQLDDKTLPCVPPISVSVPNNYPTHPPRCNANRAQYASTSFLSDVLDSLTLHLEKMPSQYSITSLLDTWEMCVRQMCTSDGAGNATSGSPVGSARQQAISS
Length554
PositionTail
OrganismTropilaelaps mercedesae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Acari> Parasitiformes> Mesostigmata> Gamasina> Dermanyssoidea> Laelapidae> Tropilaelaps.
Aromaticity0.03
Grand average of hydropathy-0.340
Instability index51.43
Isoelectric point8.70
Molecular weight58509.93
Publications
PubMed=28327890

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13373
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     301.96|      57|      57|     121|     177|       1
---------------------------------------------------------------------------
   20-   57 (59.98/27.43)	.GPVS.............RPNGPAGVGhG...........GQDPMMA.....LR..TMTNPHHQQ......QG..HSP
   63-  114 (75.89/36.95)	IGA..................NQMGSG.PIGAPADLMASQSSTPQLPngaggLN..P.MAMQIPRPIV.INQG...NP
  121-  177 (107.93/56.12)	IGATV.............RTPEQSGVG.GVGPPVQGMMTVGVPPEVK.....LR..PQMVPQQPQNLLATNQGAVQSP
  178-  234 (58.16/26.35)	MGASVtnqigcssptgfaHSPSTVGVG.G.....QGGY..............LRggP.LVARSPGSALNTPVGSVVSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.32|      56|      83|     335|     394|       2
---------------------------------------------------------------------------
  335-  394 (91.25/61.15)	IPRDHIGHVPSVTSMTRLQNDNIWQPLLDAInaNIKSPMFNHTMQRVfgPPITMLTGAAY
  420-  475 (99.07/55.05)	IPDVLQGEIAHLDQRFKVQLDPVQQSGCRTV..NLICQLDDKTLPCV..PPISVSVPNNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.53|      24|     283|     242|     265|       3
---------------------------------------------------------------------------
  242-  265 (44.64/21.41)	QQHAAGHHVGPGTSSAP.GSTEEQA
  527-  551 (39.89/18.41)	RQMCTSDGAGNATSGSPvGSARQQA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13373 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTIITLLSDPKKNPNAVVSGPVSRPNGPAGVGHGGQDPMMALRTMTNPHHQQQGHSPMSGGSIGANQMGSGPIGAPADLMASQSSTPQLPNGAGGLNPMAMQIPRPIVINQGNPMVMGQQIGATVRTPEQSGVGGVGPPVQGMMTVGVPPEVKLRPQMVPQQPQNLLATNQGAVQSPMGASVTNQIGCSSPTGFAHSPSTVGVGGQGGYLRGGPLVARSPGSALNTPVGSVVSPASQHSQQQQHAAGHHVGPGTSSAPGSTEEQ
1
264










Molecular Recognition Features






MoRF SequenceStartStop




1) MTIITLL
1
7