<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13370

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceADLNGIKWRRLSYPKETSSSSLASVGSPQSPLEDPVLGSFARCLQAGLLCAWRRVPRTDHAGLLPDPLPPGPPESLAKELWLFWCGDEPDTSSGGLLSHQLIDLEQGSWENGLAYDTRNLLFKALHNLVQRCLLQRGFIRLGRWFLQPTEWQSSHTAQTRQHGQSGAFPSSGAQSSRGASTSHARTSPLQITFAFNFFVHGDSTVCVGVDVRQHPAIQRLSRTHLAATQQTATSGTSGGGATGSTGPTGGTTGGGGGGSSSGGTGTTGTGNSGTMNNAVSNIRVLLSPFGLQATLLGAAIGKDADHAATLLNEWSHFYPLPPRDGSSGSGTTNVAGNENCPPNMDAQHGSVPGGGHETPATCGSVGGGQLPSVVSVQVGSVRMKYPSAYVFVSETDEVLHGQASAAAGMASSHMSMGTTGSAVGTPSHKGSSSKNGCTSPPRSILSAALASKDGKEQLHQVPGESSQQRVALKNLPPEENQQLGSSGMGRLSSNGTSARATRLNRITSRHIRTKAWADATSTIGLPAITHQSQQATHDQPDRNGMDTEAVAGCWQLRELISCGQQAPSCGCFRCVPGGPGGCRRDERDRSKKDLPPRLPQLKPGSAGFFHKRRGSHDIPSALDSILATRLGLASLTSSANSHPATQQSNTANSDENADKMAPPLSTGGVQVTPGDPRSTASMPPSVEAGNLASLLSPAAQPKLEPGVQVPLKLEPPGSVGGGLPPGHSPVSTPGDSARPTLGGLSPLNEDGVPGNPSSVHQGITIKQEIIGSAPSSVANMDCCATPALPDVNKSGKEGSGDNKDHSMPYAGSVLTATGVHFGHFGSHKKQGSAGTNLLKRPTLPFVSHEDADMLAPPSSDVSALYDYSAVSTALFWDAPPPSKRTFPLRLASDRYQNNNDYGANTWFQHNPNNGLSSTLSHGKQVATGGPTALHHQHSINNGAEDNLGSESGGEQTSADDGALLGALCVSPSEVTSAALTPLSSGPHSNNPSTPRQHGAALTPGGGGHGHLQSASSADRTQSGAQGAGVGTPLDCGPGDPLLDNMSSSSEGMGDAGSPDNGLLFPGPGSAGTKATGGLISTPPQHLSSCGDDLHRKTAGFVELTTMYPTPPSLEPNAAASPGNGPGTPSGPAHPALADEEPPVLQGVEPEGECTEWSMFVHRPALLNKLVSSTLYAPVAPLPSSLQAPISLPAECVYRASWQTRLNAMAGGRGGANTGGQKTPPGTQGNGVGATNSGSSGPGQMQRRHLGQDGRQNSAGTPMGGRPWGPNEGGRPAPPYPLGSPGYAAGATPGSVGPMSAGFGASRPSSVDPYQMSSGSPSVRDTSGTSSSLDKAANCPEVSSLLVTLFLSDSQLDIFRDHNFTSCTICVCNMNIKGADVPLYLPSQLLSGPALNGYDDPQYKCTCGFSAVVNRQLSYQAGLFYEDEVEITGIPYESTSAKSKLALAAALQTNVSGQKSSLQKTSNQAKHELASEPTQLLQAEKQLVEYVQRQCLGMTESPCNLLAAFNSACASSVCFPECNQPQSHGPRSLTPPLSPLAMRLFRQSRSTDKQQSSLCNENSLCVASGGDVGMPLCWAGTLQSAQQMADGCQVTALALEAALVGGMGALIQPSSQWVGRHPFDEATRAGLLHRWAFLQVGTPPNHATIVKLLRSLQPILQDGVHNQRKAQKGPSQNMWEVTYRVVGPLTWRQFHRLAGRGTEDQCEPQPIPSLLVGYDKDWLSISPFALKYWDKLLLEPYASARDVAYVVVCPDADALQGPIKAFFRELSAIYEAANLGRHCALSKSFRDGILKVGTRPALMDKKSSSEECGAAPTPGGQPSPVPAATLQLSQTTANDQRPRGIAEQQQPDEWLGDLFVQLGIVEAPEEAERSESVQNRSPNSTGTANNANPSSAPITTTSTTKSGSKGRGANKEKQQQQQQQLLLQQQQQQQQQQQQQKAGSASSATAQPPRPVKSERIIQRNALLAARLSLYSQTCRLQLAPQLAGLQLLDRSLLDGPLQANSPKMQQPPAASPRAPNTPDNPATPSVDKTNHAGSVADPNKMDVKEEGGSAAPSATASNSTTSSNSVTSQDQLQQQQQQNVASGGAIGQDNGSSQQVGTSGATGGADGVGSNTGYASPANSMASLQSGLNADDSAEPNNTPAIVLYVIDPTPLHATGDEEARRLSLLALHACFERTLSALPPHIRGNVQLQIVPLEAVLAAEQCATPAKRHDLLVQTALSLFYQSGPTLPAVTPPGQVKSLTGMGPAASQDQFIKRKMQSQRAIAESNKSTPSNGLSVNNRTAAIADAESASNGGSYIDDIRTFNPPFILAPTKDKQAELGEMFGDHQERSSILFVSYCLSEDQRWLIASVSTERGELLRNASINVAVPDRTRRKRASARFLGLNKLMEFVLDVVSTGAVRPWRLVIGRVGRIGHGELKEWAALLSRKSLLRYSRHLRDLCSQCGVLSSPLDVPCILSACLVSLEADSCLQVFADQCSPDERVSTNAQRCELSTPVDATCTHILVFPTSATTQSSQATFNHLAEDHMDLGNDDELFKTITQDMDGGPDNFDDIVNWNLDASPENTMQGGIGDDNGTGGGIGGLGGMRNSRSPNDDPMVSMMMGTGNGSGMSLSNGLPSSNIGGGGGQGVASSGGCTGSRTVGGNGYGDFLLGGEEAMQLLQQPLALGYLVSTAPAGPLPKWFWAACPHLEGANPVFLKSALVLHSPTVHQSQDDILHGNQRNGHPLDSNLTTDVLRYVLEGYNALSWLRLSPTTHDRASCLPLHVQNLLTLYHALHALL
Length2782
PositionMiddle
OrganismTropilaelaps mercedesae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Acari> Parasitiformes> Mesostigmata> Gamasina> Dermanyssoidea> Laelapidae> Tropilaelaps.
Aromaticity0.05
Grand average of hydropathy-0.407
Instability index52.12
Isoelectric point6.22
Molecular weight291147.93
Publications
PubMed=28327890

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13370
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.79|      15|      16|    1239|    1253|       2
---------------------------------------------------------------------------
 1239- 1253 (29.44/13.87)	SGPGQMQRRHLG.QDG
 1257- 1272 (26.35/11.52)	SAGTPMGGRPWGpNEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.61|      16|      16|    2616|    2631|       3
---------------------------------------------------------------------------
  244-  258 (30.70/10.08)	STGPTGGTTGGGGG.G
 2616- 2631 (29.35/ 9.24)	SNGLPSSNIGGGGGQG
 2635- 2650 (28.56/ 8.75)	SGGCTGSRTVGGNGYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.23|      16|      16|     728|     743|       5
---------------------------------------------------------------------------
  728-  743 (27.31/10.99)	SPVSTPGDSARPT..LGG
  745-  762 (23.93/ 8.54)	SPLNEDGVPGNPSsvHQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.44|      16|      20|     971|     987|       6
---------------------------------------------------------------------------
  977-  998 (19.07/ 7.60)	AALTPlSSGPHsnnPSTPrqHG
 1117- 1133 (25.38/ 7.96)	AAASP.GNGPG..tPSGP..AH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.59|      14|      16|     942|     957|       8
---------------------------------------------------------------------------
  942-  957 (20.75/13.96)	GAEdnLGS..ESGGEQTS
  961-  976 (19.84/ 6.92)	GAL..LGAlcVSPSEVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.90|      18|      22|     660|     677|       9
---------------------------------------------------------------------------
  660-  673 (20.47/ 6.18)	..............MAPPLSTGGVQ..VTP
  674-  697 (22.06/ 7.40)	GDPR......stasMPPSVEAGNLAslLSP
  699-  725 (24.37/ 9.16)	AQPKlepgvqvplkLEPPGSVGG.G..LPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.94|      15|      16|     401|     415|      10
---------------------------------------------------------------------------
  401-  415 (26.00/11.84)	GQASAAAGMASSHMS
  417-  431 (26.94/12.59)	GTTGSAVGTPSHKGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.16|      13|      15|    1275|    1288|      11
---------------------------------------------------------------------------
 1275- 1288 (23.03/11.99)	PAPPYPLgSPGYAA
 1292- 1304 (25.13/ 9.13)	PGSVGPM.SAGFGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.81|      17|      21|    1615|    1632|      12
---------------------------------------------------------------------------
 1615- 1632 (29.33/19.27)	QW....VGRHPfDEATRAGLLH
 1633- 1653 (27.48/12.84)	RWaflqVGTPP.NHATIVKLLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.09|      16|      16|    2265|    2280|      13
---------------------------------------------------------------------------
 2265- 2280 (26.95/13.71)	RAIAESNKSTPSNGLS
 2284- 2299 (26.14/13.06)	RTAAIADAESASNGGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      25.79|       8|      16|    1843|    1852|      14
---------------------------------------------------------------------------
 1843- 1852 (10.85/13.68)	GIAEqqQPDE
 1862- 1869 (14.94/ 8.35)	GIVE..APEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.92|      20|      21|     579|     598|      15
---------------------------------------------------------------------------
  579-  598 (37.83/20.14)	PGGCRRDERDRSKKDLPPRL
  603-  622 (37.09/19.59)	PGSAGFFHKRRGSHDIPSAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.10|      12|      15|    2401|    2412|      16
---------------------------------------------------------------------------
 2401- 2412 (21.97/13.62)	GAVRPWRLVIGR
 2419- 2430 (20.13/11.75)	GELKEWAALLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.05|       9|      15|    2522|    2531|      17
---------------------------------------------------------------------------
 2522- 2531 (13.06/14.63)	FNHLAEDhMD
 2539- 2547 (16.99/11.20)	FKTITQD.MD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     256.80|      61|     145|    1877|    1937|      18
---------------------------------------------------------------------------
  326-  375 (60.99/24.18)	...SSGS.GTTNVAGNENCPPNMDAQHgsvpGGGHETPATCGSVGGGQLPSVVS...........
 1877- 1937 (96.76/43.28)	QNRSPNSTGTANNANPSSAPITTTSTT....KSGSKGRGANKEKQQQQQQQLLLQQQQQQQQQQQ
 2023- 2083 (99.05/44.50)	DNPATPSVDKTNHAGSVADPNKMDVKE....EGGSAAPSATASNSTTSSNSVTSQDQLQQQQQQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.42|      17|      24|    1438|    1458|      22
---------------------------------------------------------------------------
 1431- 1447 (27.85/23.90)	TGIPYES.....TSAKSKLALA
 1452- 1473 (22.56/ 7.14)	TNVSGQKsslqkTSNQAKHELA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.96|      26|      27|    2169|    2194|      24
---------------------------------------------------------------------------
 2155- 2183 (36.84/21.38)	PLHATGDEearRLSLLALHACFERTLSAL
 2184- 2209 (44.11/27.17)	PPHIRGNV...QLQIVPLEAVLAAEQCAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     119.26|      26|      27|    1058|    1083|      25
---------------------------------------------------------------------------
  818-  841 (24.50/ 8.07)	...GVHFGHFGSHKKQ.GSAGtnLL......KRP.
  911-  929 (23.36/ 7.27)	PNNGL..SSTLSHGKQvATGG..............
 1058- 1083 (49.05/25.21)	PDNGLLFPGPGSAGTK.ATGG..LI......STPP
 1086- 1111 (22.35/ 6.57)	......LSSCGDDLHR.KTAG..FVelttmyPTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.43|      13|    1027|    1714|    1726|      26
---------------------------------------------------------------------------
 1696- 1709 (19.03/ 7.94)	LAGRgTEDQCEPQP
 1714- 1726 (23.41/11.46)	LVGY.DKDWLSISP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.69|      65|    1022|     439|     518|      28
---------------------------------------------------------------------------
  441-  509 (100.23/78.02)	PRSILSaalASKDGKEQLHQVPGEsSQQRVALKNLP...PEENQQL...GSSGMGRLSSNGTSARA....TRLNRITSR
 2309- 2383 (94.46/42.99)	PPFILA...PTKDKQAELGEMFGD.HQERSSILFVSyclSEDQRWLiasVSTERGELLRNASINVAvpdrTRRKRASAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.97|      10|     812|     259|     268|      30
---------------------------------------------------------------------------
  259-  268 (19.39/ 8.45)	SSSGGTGTTG
 1047- 1056 (19.58/ 8.61)	SSSEGMGDAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.74|      11|      26|    1389|    1399|      34
---------------------------------------------------------------------------
 1389- 1399 (20.99/13.18)	LSGPALNGYDD
 1416- 1426 (20.75/12.91)	LSYQAGLFYED
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13370 with Med13 domain of Kingdom Metazoa
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