<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13368

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMVRGGNAANIMDRLRVKQYRPWNDISRLLRQLAGEKHLFVDTEERCQLQRCLDLLQKSIKINSAQGMIERLDTITRQLGLKLTKDQKRSAERKPVELFEVFISSDMFYVEVVVESNGHVCDVKVAHHGDPVSCPELCRVLQENDFVTFTAHLEGLIAIYQLNCEKSRKQKAYVALQALESDLSTISELQKFLNDPRQLVCKSPVGILQTRRGGFPMQLTFFVSPYDLIDPSKPGGVAPFTVDSVLTRKLGQSVSISIENSGQHKLQTGSLITSIDGTNIGKMPNFGPLSQLNSVSLPACFTMKLATPMPLDSECIKKIQKVTGIEIPGSQATSHLIELITKRKQGAYFVKLPDQDHTYHMNGGQRKGAMISSIPFTHPTHVPPVLEFLRQQSLFNSLISSCVRDQPSAAPHSHVFEVQASSLTSLCVSFEHPLDNESLVTLEISLVDILGLKCKAYFCSQQSELNQFLNEDAAAKVLQLSFSIPVLMRSILKKAKGGSNKPLEELQSKSVATPSFLPGGPSGDVKREHFDGENVPSFGDTNGPRSMQQDLFDLENINSLQGGLSLNMLADDGPTSLVPGRPNPYQQQGGGASNGSGGPVSQMQRKRPREDGDFLDNRPPGFPLGAAGGPITKGQLENINNNNSDSNQQMSQQPQPGQILQSTNAKSVGDQLAAQIKRQRTEGPMEDGGLSAGGTGALNNVRDSKNLRAGGDSGESPPAKTSHTINTPSATGGVSGHTSIGGSIGGSSGSSSHGIGTSSTGSQQQQQSAPRKEKSSSSSSGGTSSKSDDKRNSSSSSSSSRDKEKRKDKDKSYSKDGSSKSSSSKSSSKDKDHKTSSKSSSSKDKDKEKSSSSGSASGSTSRGSSGMGLTVVGDKVQQGGVTTVKFSPEIGSGGNASPNKYGSSSSSSSEGQQFTVKSSSSAQGIKLTINKARTSETGGGASSTSTSSSSSSSSSKHNRDSPKPRSLSSSPSHKSKMSPSWKTSPKHSSSSGGGGGGCSGPPTGAMMMPPPPDVSANSSVELVEQCVRALHGDDSTGLTVASGAHIGPGGAASPFDSRSPVSAMGPPSVGSSSLGSVSRPSPVVIDDELMDEALCGMKNHV
Length1100
PositionMiddle
OrganismTropilaelaps mercedesae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Acari> Parasitiformes> Mesostigmata> Gamasina> Dermanyssoidea> Laelapidae> Tropilaelaps.
Aromaticity0.04
Grand average of hydropathy-0.564
Instability index60.76
Isoelectric point8.97
Molecular weight116165.27
Publications
PubMed=28327890

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13368
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     616.07|     107|     108|     738|     844|       1
---------------------------------------------------------------------------
  518-  615 (101.18/24.78)	......GGPSGdvkrehfdgenVPSFG.......DTNGPRSM..QQDL..FDL.ENI.NSLQGGLSLNmlADD...GPTSLVPGR........PNPYQQQGGGASNGSGGPVSQMQRKRPREDGDFLD.
  620-  721 (109.30/27.28)	..GFPLGAAGG...........PITKGqlenINNNNSDSNQQmsQQPQ..PGQiLQSTNAKSVGDQLA..AQIKRQRTEGPM..........EDGGLSAGGTGALNNVRDSKNLRAGGDSGESPPAKTS
  738-  844 (169.04/45.60)	SIGGSIGGSSG...........SSSHG....IGTSSTGSQQQ..QQSA..PRK.EKSSSSSSGGTSSK..SDDKRNSSSSSSSSRDKEKRKDKDKSYSKDGSSKSSSSKSSSKDKDHKTSSKSSSSKDK
  850-  912 (67.16/14.35)	SSSGSASGSTS...........RGSSG....MGLTVVGDKVQ..QGGV..TTV.KFSPEIGSGGNAS....PNKYGSSSSSSSEGQQ..........................................
  914-  992 (108.98/27.18)	......TVKSS...........SSAQG....I.............KLT..INK.ART.SETGGGASST..S..T..SSSSSSSSSKHNRDSPKPRSLSSSPSHKSKMSPS......WKTSPKHSSSSGG
 1021- 1087 (60.40/12.28)	LVEQCVRALHG...........DDSTG....LTVAS.GAHIG..PGGAasPFD.SRSPVSAMGPPSVG..SSSLGSVSRPSPVVIDDE.........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.97|      22|      25|     382|     406|       2
---------------------------------------------------------------------------
  382-  406 (35.68/27.65)	PPVLEFLRQQSlfnSLISSCVR.DQP
  410-  432 (36.29/19.91)	PHSHVFEVQAS...SLTSLCVSfEHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.08|      19|      20|     195|     213|       3
---------------------------------------------------------------------------
  195-  213 (35.42/21.95)	PRQLV.CKSPV...GILQ.TRRGG
  215-  235 (26.20/14.15)	PMQLTfFVSPY...DLIDpSKPGG
  478-  497 (18.45/ 7.59)	..QLS.FSIPVlmrSILK.KAKGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.02|      22|      22|     313|     334|       7
---------------------------------------------------------------------------
  312-  333 (36.80/21.28)	S..ECI.KKIQKVTGIEIPGSQATS
  334-  358 (30.22/16.25)	HliELItKRKQGAYFVKLPDQDHTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.36|      12|     273|     183|     194|       8
---------------------------------------------------------------------------
  183-  194 (21.38/16.23)	STISELQKFLND
  459-  470 (21.98/16.93)	SQQSELNQFLNE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13368 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLSLNMLADDGPTSLVPGRPNPYQQQGGGASNGSGGPVSQMQRKRPREDGDFLDNRPPGFPLGAAGGPITKGQLENINNNNSDSNQQMSQQPQPGQILQSTNAKSVGDQLAAQIKRQRTEGPMEDGGLSAGGTGALNNVRDSKNLRAGGDSGESPPAKTSHTINTPSATGGVSGHTSIGGSIGGSSGSSSHGIGTSSTGSQQQQQSAPRKEKSSSSSSGGTSSKSDDKRNSSSSSSSSRDKEKRKDKDKSYSKDGSSKSSSSKSSSKDKDHKTSSKSSSSKDKDKEKSSSSGSASGSTSRGSSGMGLTVVGDKVQQGGVTTVKFSPEIGSGGNASPNKYGSSSSSSSEGQQFTVKSSSSAQGIKLTINKARTSETGGGASSTSTSSSSSSSSSKHNRDSPKPRSLSSSPSHKSKMSPSWKTSPKHSSSSGGGGGGCSGPPTGAMMMPPPPDVSANSSVELVEQCVRALHGDDSTGLTVASGAHIGPGGAASPFDSRSPVSAMGPPSVGSSSLGSVSRPSPVVIDDELMD
2) PLEELQSKSVATPSFLPGGPSGDVKREHFDGENVPSFGDTNGPRSMQQDLFDLEN
562
501
1090
555










Molecular Recognition Features






MoRF SequenceStartStop




1) IKLTINKA
924
931