<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13366

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEQVYSVFRRSSSLPNAEWRERALKCSVSSRSALAFTADSLNGPGRVLSFEVYVTDLNTPWHPWRVLNHNEEITCLEWDSSGTRLMVGDAVGSILIFQMNNFLLNQWTLVSTTKFPGEHLLAGVWFHSGKKVAVNIEKKDSCMYLEKYSHLKFEPSMKRMGGKRSEGCLAISASGLVCVVLLCGNNTVVSSSQPLTYFRNRLQLVDLNYGKNGSIVAICSDGLSRSPVRCFAIVLVMDQDKCQINIEPFSGFCPNSQIEDGYRRVTHLRCVLKEASDAVVVSVTNGQQNILELWELTEETVSLHPLVGKCENRTSVSWRLHAVSSHSSPVAALATPRLSLYELSRPQSCIVVAFRDHSVKCFAREKLTCLSSVSTMVSPHAIKSQQHSQISYMCISHTGCVLIALDSLSQLALFRLPPVTEPAAPISVPFAATVLEYCLITGVDWWDVLVSLRPGLIEKVSEKLCEVFDKQPPGVQQFYESRFLAIKGSLYRLLNMGFIKAGDCHAQMMLSAVSCGIKALLRPRETKPDGSPADTLSALINDRAQVSNTMDKVLMNLDTKEFFVEPAILPSVQHHVQWVSDLALHLMASLPLQICQRQRFPGGGLIQDAKSINTIRELLVIFRMWGILSESCLPVYTRMTENLDVLGVLFKLLTKTLMNHGSEPDTTLLEECSVLPSQILIPSLDLASHSHEGVCGPALFVQPLPLALEFGVMADFVATHHHKTAGTVEGSVRSTSHTDIVRHISLGKHVVQVRKCTRCFSLSMLRSSQNLSVMRAWEQRWLRCCPCGGQWMLF
Length794
PositionTail
OrganismTropilaelaps mercedesae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Acari> Parasitiformes> Mesostigmata> Gamasina> Dermanyssoidea> Laelapidae> Tropilaelaps.
Aromaticity0.07
Grand average of hydropathy0.071
Instability index46.18
Isoelectric point8.14
Molecular weight88268.41
Publications
PubMed=28327890

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13366
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     521.06|     133|     184|     324|     464|       1
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  190-  314 (116.67/73.36)	.SSSQPLTYF.RNRLQLVDLNYGKNGSIVAIcSDglsrSP.VRCFAivlvMDQDKC....QINIEPFS.GFCPNSQIedGYRRVTHLRCVL..........................................keasdavvvsvtngqqniLELWELteeTV.SLHP.LVGKCENRT
  324-  464 (208.67/160.52)	SSHSSPVAALATPRLSLYELSRPQSCIVVAF.RD....HS.VKCFA....REKLTCLSSVSTMVSPHAIKSQQHSQI..SYMCISHTGCVLIALDSLSQLALFRLP..PVTEPAAPISvpfaaTVLEycLITG..................VDWWDV...LV.SLRPgLIEKVSEKL
  511-  643 (195.72/128.61)	SAVSCGIKALLRPRETKPDGS.PADTLSALI.ND....RAqVSNTM....DKVLMNLDTKEFFVEPAILPSVQH.HV..QW..VSDLALHLMASLPLQICQRQRFPggGLIQDAKSIN.....TIRE..LLVI..................FRMWGI...LSeSCLP.VYTRMTENL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13366 with Med16 domain of Kingdom Metazoa
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