<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13365

Description Mediator of RNA polymerase II transcription subunit 14-like
SequenceMDKAMVMTGATGAPPGGTGGPVTIPLGRLIDFVLQKTYHELTVLAELLPRKSDMERKIEITTFTNTTRQLFVRLLALVKWAASAGKVEKCASMVNFLDKQSLLFIEAADMFALLARDTLVQARLPSFHIPCAAEILTTGTYSRLPTCIRDKIVPPDPISTDDKRSTLERLNRIIQYRLVSSELPPQMSSLEIKRGRVIFRVNNEFEVSLTLMGDGPQVPWRLLSINILVEDKDTGDCRALVHHLQVTYIHQLVQSRLVDHPKPLHELFECLHFFCLSLQLEVLHSQILRLCRERLGDSVRIEEYVPGSSLRLHFWREHISLLDHRPFLLMVHVDAEQPCKPLQVSHSPEITEKAEQVWIEPCIRSEFLSIEKLLIQTIHIRSRQKLAYVKDNYLKELLPAGVECTLSGSPPLLQLPVVYPCPSSEHLVLTVDTHTGYVMAFVPQFDPPMVPELQDTINSLVKDALPSLKVRLASAMLNLKFWMTLKRCKKTVQHLPVLAMETNPFVHAPEEHRINQLAKYSLFVKLCKHAHYYVVIELQAEKPSDNIEFHYYLMSATNDNRLSSFYELDGHSIVHGPCTDVDILAPSPSAIGLLNSMHNANTDSLKRSAEPLDTSVSSKKPRCSGYFFSDVAHIVAFCDDRLPFCSLTRELEARGICHRGLQIEGAQTNFCVKIVQMPLAKENDLPISVVEELRHSLLSCTFRLQVKGIKAWLCELVFHDCPLTTSNVRERGPTRPVYFMYDFSQNNMAAVVDEWLADWAVVCKLYGVMAKYASDMKKPKYTALLEMSEVRSYTYTRLTLAYGPEKNDTVTLSWRAVERRFQLVFGVVGPSVSATNPHATIAHQLSYDFNQHESVIQLLQALRDTYRPLLSLSRLPSTPQLGVINSRPTVPVQTFVIIPQSSTCFKLIYRGNYCLEVQCRKGDGCVIIRDGAFSHFDKGRHVEEFMPIPGLRAFLGKFTGGCEAPHDPDNPVSPLALESVDAFLSPSQAKGAAASSPASNRSATTDNALRFPQHHPMTPPSNPHTPASPHPSMLPSNYTASPNPSYVHTPSNIPPSSPLAPPPSSPYPVNSPHMTSPSPSPAQQPPSQQSFASAAAPNDPTSPAFPMLSASPANAWPSSPAPPRPSPRPFQPSPGGPSPAQPPSVEVRQPPAMSRMAPPHPGNWAAAMPIVLTHEKLDQLCTPTSPCLSPMERFLGCAFMRNFIVRYEESAQGRTPTGLIPDSGIVTFRLEPFVYRVSLNPATMQSLHVKISPIDPNKEQLFSAEEIQVVERYFDAKVSSIPYKPNAFMSFSRLMGCTQRILRDFIQLMRLELCPPQTPMFRWNFQLCLTIPPAVPQIAPPGMTSVLISRNKMLFFMQLSPARPQGEPPGVQINLPGQPSLVVPLVYDFQMNSMSTAADRRVNGDLSTQNAQAMNIITQILRQGPEYQNGGECTIFASIRDVLTQLVIN
Length1449
PositionTail
OrganismTropilaelaps mercedesae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Acari> Parasitiformes> Mesostigmata> Gamasina> Dermanyssoidea> Laelapidae> Tropilaelaps.
Aromaticity0.08
Grand average of hydropathy-0.148
Instability index56.40
Isoelectric point7.94
Molecular weight161576.79
Publications
PubMed=28327890

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13365
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     163.72|      21|      21|    1042|    1062|       1
---------------------------------------------------------------------------
  997- 1020 (29.35/10.04)	PA.SNR.SATTDNalrFPQH.HPMTPP
 1042- 1062 (44.45/19.38)	PN.PSY.VHTPSN...IPPS.SPLAPP
 1063- 1085 (27.01/ 8.59)	PS.SPYpVNSPHM...TSPSpSPAQQP
 1103- 1123 (35.96/14.13)	PAfPML.SASPAN...AWPS.SP.APP
 1125- 1138 (26.96/ 8.56)	P........SPRP...FQP..SPGGPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.75|      26|      52|     105|     130|       2
---------------------------------------------------------------------------
  105-  130 (44.50/24.72)	IEAADMFALLAR.DTLVQARLPSFHIP
  158-  184 (39.25/21.03)	ISTDDKRSTLERlNRIIQYRLVSSELP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.84|      24|      27|    1315|    1341|       3
---------------------------------------------------------------------------
 1318- 1341 (49.38/26.50)	TPMF..RWNFQLCLTIPPAVPQIAPP
 1344- 1369 (39.46/13.30)	TSVLisRNKMLFFMQLSPARPQGEPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.07|      45|     134|     457|     511|       4
---------------------------------------------------------------------------
  466-  511 (75.21/58.94)	PSLKVRLASAMLNLK.....FWMTLKRCKKTVQHLPVLAMETNPFVhAPEE
 1143- 1192 (76.85/39.69)	PSVEVRQPPAMSRMApphpgNWAAAMPIVLTHEKLDQLCTPTSPCL.SPME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.08|      14|      57|     965|     979|       5
---------------------------------------------------------------------------
  965-  979 (23.99/14.85)	PHDPDNPvSPLALES
 1023- 1036 (30.09/15.00)	PHTPASP.HPSMLPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.91|      14|      27|    1250|    1263|       6
---------------------------------------------------------------------------
 1250- 1263 (26.27/18.02)	KIS..PIDPNKEQLFS
 1277- 1292 (22.63/14.24)	KVSsiPYKPNAFMSFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.87|      23|      56|     361|     389|       7
---------------------------------------------------------------------------
  361-  389 (34.89/31.12)	PCIRSEFlsieklLIQTIHIRSRQKLAYV
  420-  442 (42.98/25.21)	PCPSSEH......LVLTVDTHTGYVMAFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.04|      32|      60|     723|     782|       8
---------------------------------------------------------------------------
  723-  757 (48.83/34.52)	LTTSNVRERGPTRpVYFMYDFSQNNmaAVVDEWLA
  785-  816 (55.21/77.76)	LEMSEVRSYTYTR.LTLAYGPEKND..TVTLSWRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.06|      11|     235|     669|     721|      10
---------------------------------------------------------------------------
  657-  667 (21.03/45.43)	CHRGLQIEGAQ
  700-  710 (20.03/13.12)	CTFRLQVKGIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.92|      17|      27|     896|     916|      12
---------------------------------------------------------------------------
  896-  913 (26.63/24.13)	VIIPQSSTCFkLIYRGNY
  917-  933 (31.29/13.82)	VQCRKGDGCV.IIRDGAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.17|      12|      99|    1193|    1204|      21
---------------------------------------------------------------------------
 1193- 1204 (25.00/16.93)	RFLGCA..FMRNFI
 1293- 1306 (19.16/11.13)	RLMGCTqrILRDFI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13365 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PSQAKGAAASSPASNRSATTDNALRFPQHHPMTPPSNPHTPASPHPSMLPSNYTASPNPSYVHTPSNIPPSSPLAPPPSSPYPVNSPHMTSPSPSPAQQPPSQQSFASAAAPNDPTSPAFPMLSASPANAWPSSPAPPRPSPRPFQPSPGGPSPAQPPSVEVRQPPAMSRMAPPHPGNWA
986
1165










Molecular Recognition Features






MoRF SequenceStartStop




NANANA