<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13352

Description Uncharacterized protein
SequenceMLTRPPVSSTSRPPLPTRSVTIGQQYPHTQQLRRPAPPSRLSSVRSASGPSQHVNLDEYDSAWRNEVAQKNNASLGHVESGEDVAEEGRPRKKAKIESEGIMVSSPTDLNDEVHDIPPDEAHALLPGAPMPLPPGPQPALRKPAPKNQLNHDPLRKATGLQPSAIAIRLPAPKSIADFSPWSGTHPEDVLNETIIKGGYYDKPPNPSQNETNSARHSIWPNLSQKNNVALHTLSHLFTQVLEKRAAMGRITAPSSFKPPPRVTVTDTKREAWLKDLANLAIPLRRQSRTIPHGIRGKGLLEQCLAKEIPLSRAIWLAKCVGANELRAFRRKGVSGTAGAQGEAKWLRDWTVGVQQFFEGVVAECGKEDWRKQIDYAIKLTSSLYTEGLVEKEEYLDWVVRMLGSAEEKNLPLWAIMVQIYWKELVKSGYRGRRLATAILEHLHGLEAQTSTACVALKERLRKLIAILAVTEQGCLVVPATWEKYKHLLSPVERAIPVHLRVAVTSVTRRNERLAAPMTRTSRNTRSRMLRLVDLLDAVDLRLDIVKLASQCLALLPDINGLVSGLLSWTSSSFRSGDARVYVAAGVLEQLYKAGYDIDNAISAYLQTDVEITPAETKNVGLVVAQLVQRDCFAVGVYLQWLIVNGAASTRSSPTPTASILTALPREKIPRQLASLREALLARYGLVAHESAAICSMSDGITLDLQEGSTKYIDRSGMLQSLSTSARSTLSTSLVQRIALQAKHDGITNANFCLLRDVFEQACQHLAISALIVATTATDDFAALASATDTLATYALALAALGQLSPLFHALYNQHVQLRTHRDFDRTFLLALLRLAVRLPGLDPSVAILLKNDLILCDQRSSAAACSPASDNLVSIIAEQLDSDDQIDAVFASGNTMDEATFNRVFLRVMARADGVGNDGKTAQSRLCGWVEQLRVIDAPELEKLGKEYVSLVMSKGDVMVAIPAGVVALVASGCLTIDSIYPTSGACDQPSVALSWLRFLAEPLTLGTFTTSELYAFELQRQQFCDEEHVKVTELLCRVADLDTPATESTWVMNLSLRLNVASKGEQSLLDDRRLPGSVSKTILQCKRPIARILDLCEIIHTADALNIAVTINWLQAQALTPGSSNWNGEIRHALLEAFRSDSVVWPQLLSAAPPEMLKSIHESAVDLVLLAASSGSQDNDAATAKMTERCCMLMDLTYPAVCTHDNTHVFTTVSDRIKVITTALGESDIASQHQLVANLQTLLHVLALYSSSPSETSDTQARVRVSTVLLSLLARPLQQQGSPLPQDTMECIHDVAALYIDALSPAELSGLLKALPVPAAKSHYFASLLPDSRPQDANLALATRVPASRPSRALPPSAAARPPAPVRPRPPFPQSGSAVPFPQPGSAVPLEIIPPRQATQQVPIPSEVKYAPFQVKRWEVLPDATPTVGENDCAIGLGMFGARKV
Length1446
PositionKinase
OrganismRachicladosporium sp. CCFEE 5018
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium> unclassified Rachicladosporium.
Aromaticity0.05
Grand average of hydropathy-0.096
Instability index50.36
Isoelectric point7.35
Molecular weight157449.66
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13352
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.43|      22|      24|     125|     146|       1
---------------------------------------------------------------------------
  125-  146 (44.93/21.26)	LPGAPMPLPPGPQP...ALRKPAPK
  149-  173 (34.50/14.60)	LNHDPLRKATGLQPsaiAIRLPAPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     293.31|      99|     154|     986|    1085|       2
---------------------------------------------------------------------------
  986- 1085 (164.77/107.70)	AC......DQPSVALSWLRFLAEPLTLGTFTTSELYAFEL.......................................QRQQFCDEEHVKVTELLCRVADLDTPAT...ESTWVM.NLSLRLNVASK..GEQSLLDDRRLPGSVsKTILQ
 1096- 1245 (128.54/79.11)	LCeiihtaDALNIAVTINWLQAQALTPGSSNWNGEIRHALleafrsdsvvwpqllsaappemlksihesavdlvllaasSGSQDNDAATAKMTERCCMLMDLTYPAVcthDNTHVFtTVSDRIKVITTalGESDIASQHQLVANL.QTLLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.67|      20|      21|    1371|    1391|       3
---------------------------------------------------------------------------
 1371- 1391 (34.60/19.66)	PPfPQSGSAVPFPQPGSAVPL
 1395- 1414 (38.07/17.57)	PP.RQATQQVPIPSEVKYAPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     349.80|     121|     154|     563|     715|       4
---------------------------------------------------------------------------
  563-  700 (185.53/152.06)	SGLLSWTsssfrsgdarvYVAAGVLeqlyKAGYD.IDNAISAYLQTDVEITPAETKNVGLVVAQLVQRDCFAVGVYLQWLIVNG...AASTRSSPTPTA................SILTALPR..EKIPRQLASLreALLARYGLV...AHESAAICS.MSDGI
  726-  872 (164.28/86.26)	RSTLSTS...........LVQRIAL....QAKHDgITNANFCLLRDVFEQACQHLAISALIVATTATDDFAALASATDTLATYAlalAALGQLSPLFHAlynqhvqlrthrdfdrTFLLALLRlaVRLPGLDPSV..AILLKNDLIlcdQRSSAAACSpASDNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.81|      19|      23|      69|      87|       5
---------------------------------------------------------------------------
   69-   87 (32.10/27.29)	QKNN.ASLG.HVESGEDVAEE
   92-  112 (21.72/15.27)	KKAKiESEGiMVSSPTDLNDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.55|      13|      15|    1326|    1338|       6
---------------------------------------------------------------------------
 1326- 1338 (22.73/10.28)	FASLLPDSRPQDA
 1342- 1354 (22.82/10.36)	LATRVPASRPSRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.61|      14|      24|       5|      18|       7
---------------------------------------------------------------------------
    5-   18 (26.93/12.59)	PPVSSTSRPPLPTR
   27-   40 (27.68/13.16)	PHTQQLRRPAPPSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.56|      24|      24|     345|     368|       8
---------------------------------------------------------------------------
  315-  341 (28.38/15.26)	WLA..K.CVGANE..LraFrrKGVSGTAGAQG
  345-  368 (45.48/28.63)	WLR..DWTVGVQQ..F..F..EGVVAECGKED
  369-  393 (23.71/11.61)	WRKqiDYAIKLTSslY..T..EGLVE...KEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.54|      23|      26|     887|     912|      11
---------------------------------------------------------------------------
  887-  909 (40.14/29.51)	DAVFASGNTMDEATFNRVF.LRVM
  913-  936 (37.39/18.99)	DGVGNDGKTAQSRLCGWVEqLRVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.29|      16|      21|    1137|    1152|      13
---------------------------------------------------------------------------
 1137- 1152 (28.86/18.31)	EAFRS..DSVVWPQLLSA
 1156- 1173 (20.44/10.69)	EMLKSihESAVDLVLLAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13352 with Med12 domain of Kingdom Fungi
Unable to open file!