<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13349

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMDNNDLADAVMAEIQIPSASMMDSMDDLFGEPTNLVVQAPLLPGPPPPAELVLRIAEMQRAGCCTKLAWCNNGCIARISPDGGQVNFHVTMDDASTGAQCVSDASSNPIIAQTGSEFVHLQYTSLGQELAVVDSVGNVQVFTGSTGLGRMSFAPTTGDSEAEGGRSDLDAVVGMYWLPQWPMDFRIPYVGPAVKTDGTWSTKLHYPDQQAPRLHHPVDGKTAFLYVTRNTSLTLCYQHDATKWGTASNTLESLSTLDETLSHAAFCQQDDKLLLVTHDLRRHMRVYTITIDWNGTQGKDQYRSGTLRIAPSLLFGHTVSLEYVAPQHSEGTLLTSLQIIPPVPIFAESSFPSYTTIVATFAQASYPADATQQAQSFTTICRWHLEQLTQNLHPSFAKLQKRAAPAVTLPNKNILRQQPDLVTAKVILTIQPMNHDTLIAFGASDGTVECRDRETWNVTAPTFGGTTTVTSLPQAGFEFTPSLEHSVHIACNTDCAYMITLGVDQKLRCKPAALRYGWQAIDDGILDISGMHETAIACVAREHTLLTHHSNASALEMFALLPPDLSPEQYRHLLFDITRALTRAHDLGSLDEKTKQRMLLGDNYIIRCLGAQLSLVPAPDAQPGIGAQLAWMVLTAKQAHFALFSSCSSTSPPDPATLHSLRGLAIWSLDLFTASLAALCAVHSSIAIKSDETPAAALRVHIASSSSSLLHLVLCSYPRTLLRYLALALTRYFKLVASSLPSSPSLQIKTDLLETISKIKTLPFRLEILAAPNGLLGEIDRAASEAYTAVGPRERSEIELTMLISPTPDVPAIMESAAESIWSRVLPRYLGEMDLGALYFLNASGLSLPSRETIGKSAKRKVDVLTKLPITGGEFSLLALSALAASVSAQQSSPDLVSIISVLQTGLPSSILQEALTNSAGLSSEIASEFRVATPTWFTALPTDIQTYLISAANSPSAFANATAGIASTLNGTAIMNSTSVAAAQSSILSSNSAEISSEVASASAAGTTSGGAGSGAATATSAGASSSSSAAGASMPTALYGMGLAGAVGLMGVLAL
Length1060
PositionTail
OrganismRachicladosporium sp. CCFEE 5018
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium> unclassified Rachicladosporium.
Aromaticity0.06
Grand average of hydropathy0.091
Instability index40.45
Isoelectric point5.43
Molecular weight112662.93
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13349
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.05|      23|     106|     720|     745|       1
---------------------------------------------------------------------------
  720-  745 (35.27/36.88)	YPRTLLRYLA....LALtrYFkLVAS..SLPS
  825-  853 (36.78/25.17)	WSRVLPRYLGemdlGAL..YF.LNASglSLPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     205.69|      49|     133|     875|     925|       2
---------------------------------------------------------------------------
  875-  925 (72.44/43.44)	GGEFSLLALSALAASVSAQQSSPDlvSIISVLQTGLPSSILQEALTNSAGL
  938-  981 (64.35/33.24)	PTWFTALPTDIQTYLISA.ANSP...SAFANATAGIASTLNGTAIMNS...
 1009- 1054 (68.90/36.15)	AGTTSGGAGSGAATATSAGASSSS.....SAAGASMPTALYGMGLAGAVGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     382.41|      95|      96|     433|     528|       3
---------------------------------------------------------------------------
  242-  303 (57.53/25.37)	.......................HDATKWGTASNTLESLSTLdET.L....SHAAF.....................................................CqQDDKLLLVT..HD.LRRH............MRVYT....ITIDWnGTQGKD.....
  305-  429 (61.12/27.62)	...YRSGTLrIAPSLLFGhTV......SLEYVAPQHSEGTLL.TS.LqiipPVPIFaessfpsyttivatfaqasypadatqqaqsftticrwhleQLTQNL.HPSFAKL.QKRAAPAVT..LP.NKNI............LRQQPdlvtAKV..............
  433-  528 (166.05/90.09)	IQPMNHDTL.IAFGASDG.TVeCRDRETWNVTAPTFGGTTTV.TS.L....PQAGF........................................EFTPSLEHSVHIAC.NTDCAYMIT..LG.VDQK............LRCKP....AALRY.GWQAID..DGI
  531-  628 (97.72/48.23)	ISGM.HETA.IA..........CVAREHTLLTHHSNASALEM.FAlL....PP...........................................DLSP..EQYRHLLF.DITRALTRAhdLGsLDEKtkqrmllgdnyiIRCLG....AQLSL..VPAPDaqPGI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13349 with Med16 domain of Kingdom Fungi
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