<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13344

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDNNDLADAVMADIQIPSASMMDSMDDLFGEPTNLVVQAPLLPGPPAPAELVLRIAEMQRHGCCTKLAWCNNGCIARISPDGGQVNFHVTMDDASTGAQCVSDASSNPIIALTGSEFVHLQYTSLGQELAVVDSVGNVQIFTGTTGLGRMSFAPTTGDSEAEGGRSDLDAVVGMYWLPQWPMDFRIPYIGPAVKTDGTWSSKLHYRDQQAPRLHHPVDGKTAFLYVTRNTLLTLCYQHDATKWGTASTTLEPLSTLDETLSHAAFCQQDNKLLLVTYDLRRHMRVYTITIDWNGTQGKDQYRSGTLRIAPSLLIGHTVSLEYVAPQDSEGTLLTSLQIILPVPIFAESSVPSYTTIVATFAQASYPSDAKQQAPSFTTICRWHLEQSTQNLHPSFAKLQKRAAAAVTLPNKNILRQQPDLVTAKIILTIQPMNHDTLIAFGASDGTVECRDRETWNIVAPTFGDTTTVTSLPQAGFDFTPSLEHSVHIMCNTDCAYMITLGVDQKLRCKPAALRYGWQAIDDGILDISGMHETAIACVAREHTLLTHHSNASALELFALLPPALAPEQYRHLLFDITRALTRAHDLGSLDEKTKRRMLLGDNYIIRCLGAQLSLVSAPDAQPGIGAQLAWVVLTAKQAHFALFSSCSTTSPPDPATLHSLRGLAIWSLELFTASLATLFTVHSTLVAKPNETPATALASHIASSSSPLLHLVLCSYPRTLLRYLALALTRYFKLVASSLVNSPSLLIKTDLLETISKIKTLPFRLEILAAPNGLLGEIDRVVGEAYAVSTIGPRERAEAELTMLFSPAPDLPTSLTGAVKSIWTRVLPKYTEEMDLGALYFYDTAGLMLQSRERTGARAKRSVDVLTKLPIAEVFSLLALSALAASVSAQQSSPDLVSIISVLQTGLPSSILQEALTNSAGLSSEIASEFRVATPTWFTALPTDIQTYLVSAANSPSAFANATAGIASTLNGTAIMNSTSVAAAQSSILSSNSAEISSEVASASAAGTTSGGAGSGAASATSAGAASSSSAAGASMPTALYGMGLAGAVGLVGVLAL
Length1057
PositionTail
OrganismRachicladosporium sp. CCFEE 5018
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium> unclassified Rachicladosporium.
Aromaticity0.06
Grand average of hydropathy0.121
Instability index39.98
Isoelectric point5.57
Molecular weight112564.97
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13344
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     302.69|      97|     210|     467|     594|       1
---------------------------------------------------------------------------
  467-  578 (154.81/129.75)	TVTSLPQAGFdftpSLEHSVHIMCNTDCAYMITL.GVD.QKLRCKPAALRygwqaiddgilDISGMHETAIACVAREH.TLLTHHSNASALELFALLPPALAPEQYRHLLFDITR
  631-  730 (147.88/74.87)	VVLTAKQAHF....ALFSSCSTTSPPDPATLHSLrGLAiWSLELFTASLA...........TLFTVHSTLVAKPNETPaTALASHIASSSSPLLHLVLCSYPRTLLRYLALALTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.26|      20|      20|     998|    1017|       2
---------------------------------------------------------------------------
  979-  995 (18.35/ 6.84)	TSVAAAQSSILSSNSAE...
  998- 1017 (31.87/18.03)	SEVASASAAGTTSGGAGSGA
 1018- 1034 (21.04/ 9.07)	...ASATSAGAASSSSAAGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.46|      14|      20|     343|     362|       3
---------------------------------------------------------------------------
  343-  356 (26.13/22.26)	PIFAESSVPSYTTI
  366-  379 (26.33/ 8.90)	PSDAKQQAPSFTTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.45|      31|      33|     876|     908|       4
---------------------------------------------------------------------------
  876-  908 (40.35/32.21)	SLL..ALSAlAASVSAQQSSPDLVSIISVLqTGLP
  910-  942 (48.10/28.84)	SILqeALTN.SAGLSSEIASEFRVATPTWF.TALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     218.03|      67|     164|      38|     113|       5
---------------------------------------------------------------------------
   38-  113 (104.91/95.30)	QAPLLPGPPAPAELVLRIAemqRHgccTKLAWCNNGCIARISPDGGQVNFHVTMDDA.STGAQCVSDassNPIIALT
  209-  276 (113.12/75.67)	QAPRLHHPVDGKTAFLYVT...RN...TLLTLCYQHDATKWGTASTTLEPLSTLDETlSHAAFCQQD...NKLLLVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.14|      14|      20|     428|     441|       6
---------------------------------------------------------------------------
  428-  441 (26.42/16.45)	TIQPMNHDT..LIA..FG
  446-  463 (15.72/ 7.07)	TVECRDRETwnIVAptFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.25|      12|      61|     742|     758|       7
---------------------------------------------------------------------------
  742-  758 (13.60/19.10)	SPSlliktDLLETISKI
  770-  781 (20.65/12.33)	APN.....GLLGEIDRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.75|      31|     190|     600|     630|       8
---------------------------------------------------------------------------
  600-  630 (57.22/35.25)	GDNYIIRCLG......AQLSLV..SAPDAQPGI.GA.QLAW
  783-  823 (35.53/18.92)	GEAYAVSTIGpreraeAELTMLfsPAPDLPTSLtGAvKSIW
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13344 with Med16 domain of Kingdom Fungi
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