<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13326

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPGSSAALTNGTSMVNGDAHLPNGNGHNAHDDGPPPPLDQSWREEGANVSLGKMLERLAQFCITDLTALVDELEEMPVQPSAAPVNGMTVLEDNDEVSVAKKRKIMDFAREQRDRFIRALVISDFSRNADDVANVIDVNLHLRKNDFAVAESIRSIGQLKLDSAQAKHPNPNIELAMELLSTGKTPSAPEFGYLPPPQITAQDLLKTLREMNVMLAARLNLHEDVPTVLNPIQLQMAERHSWYRQNLKFLFKSSAESMACGLREHFEVEVNRAIRDNGLQGCYDTLHNFVLTHKINILHQQAGDLHKGRWYDTIKVDRMRRNLVVQYWTGRPGKKHWLEFGIASGAGKGKTVRKVASPVISVRWFQSSVEVKDTGLDIDWQQICLEDILLQTTAKHALAMLTAARSGMQTLTSGLLGMSMSVDVAEDSAAEHVLALRFPPLRRELRLSILAIDGQYSIAPPSAAAAHAQQRLNEDSTIDVPRRLASTLSAVTFETMHREATNLRWTQLADLARQGNLNALFGSDHWQWRAYVPNTSWGIDWAIGLTISPTGLKWWTVQLQTASDGNGRIVTLAHELSMSADTESVPSRKLLLQVARQAVAQVSFTVISLQLQTMQIPFRVEKQKLMSSDPSSATQRRTVMFIQFAKLVKRYPDKKWKPWALEPVRVTHHGVERKPGDDNSTTLRCRHDLRLALKEGTFTRLRQHLSRSQDRSISISTSGGLAIRLSTALGAPFIDQLQDRLASVYRLDRYVSILHNAQARCDSVSLGNLSFTYKSSSSYRAHLTFPSTSTQRTRLRLEPPDSNPHARIRIHLENSLNTARSQPFEQFVTLLLLTLPLLTAPCLAGRSVLLQPRSASWYSLKYLSPLPAVTFTLRIRVKSNSSTGSGQELKWHIEQERTKVNAESLPTELIASLRDLWKTSDPKIGYIGLGNGLVTDAKGISKALANIDNVVRGFGGAEKGALAKSEVRTGSARTPAGGEATVKSELKDSKVDVIAID
Length998
PositionTail
OrganismRachicladosporium sp. CCFEE 5018
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium> unclassified Rachicladosporium.
Aromaticity0.06
Grand average of hydropathy-0.305
Instability index43.03
Isoelectric point9.34
Molecular weight110722.99
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13326
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     199.63|      59|     159|     362|     424|       1
---------------------------------------------------------------------------
  362-  424 (88.32/76.68)	SVRWfQSSVEVKDTGLDIDWqQICLedILLQTTAKHALAMLTAARSGMQTLTSGLLGMSMSVD
  524-  582 (111.31/77.90)	SDHW.QWRAYVPNTSWGIDW.AIGL..TISPTGLKWWTVQLQTASDGNGRIVTLAHELSMSAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.90|      45|     256|     435|     487|       2
---------------------------------------------------------------------------
  435-  480 (71.08/48.53)	LAL...RFPPLRRE...LR...LSILAIDGQYSIAPPSAAAAHAQQRLNEdSTID
  490-  517 (12.78/ 7.98)	SAV...TFETMHREatnLRwtqLADLARQGN........................
  692-  736 (60.04/34.28)	LALkegTFTRLRQH...LS...RS...QDRSISISTSGGLAIRLSTALGA.PFID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.13|      18|     158|      22|      39|       3
---------------------------------------------------------------------------
   22-   39 (37.77/19.29)	LPNGNGHNAHDDG..PPPPL
  181-  200 (30.36/14.22)	LSTGKTPSAPEFGylPPPQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.02|       8|     612|     242|     251|       4
---------------------------------------------------------------------------
  242-  251 (13.19/13.30)	SWYrqNLKFL
  857-  864 (17.83/ 9.75)	SWY..SLKYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.46|      10|      15|     106|     115|       6
---------------------------------------------------------------------------
  106-  115 (19.07/11.42)	IMDFAREQRD
  123-  132 (18.40/10.78)	ISDFSRNADD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13326 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAPGSSAALTNGTSMVNGDAHLPNGNGHNAHDDGPPPPLDQSWREEG
1
47










Molecular Recognition Features






MoRF SequenceStartStop




NANANA