<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13325

Description Lactoylglutathione lyase (Fragment)
SequenceTQPAGTLHDAPQASGSGGSGEDVGGAEQADPRPRGHSIASSVGATHGYVGQHEDLFGDLGGDEVDEEDFSFFDEPDDMRVIGSVAVPAADADVAMTEHGGADDPLSPNAEPLGASPRLDVEEAEELSMQNTMMIASTATDATDNAITIDGGYAPSGGNGDSLSFDTETPRPHAATLDHRPLSLLTIKEQLLPPPIPASASTDQPHNTAAQKKGSFAPLAFGQRYNTSAPSRLSLPSENGQHGVSSKSARPAPTSMRGILKQSDSTDESSEADGRSDTPVSSETSSSSASSPDMEIVMHQEAATGPHTSRKRKRSALLESAVIGTNPSDWIARLPMFNQIASDHTYLQDLRRKARDMTATACSVFGGADQPARHKNEHAQRLWDDFNGQDLVMISQIVAEQAITTTHSIVDDLQVLKLDDIPLDSALASTAASTVLGILNGIVPATKPSDLATLVMTRELPTRPTPANATAAKSSGQPRPPPPRHDAMITAGPDVQSLAIPYMRVTRASDTIELLPTAMPFWDALGLGPVSGAKKVRYYCVAPKSDHLGDIVETFLHELSQAFEGSNLGQHRAVGATDESVPVARWQWLLSVDCVASAAARDTRSNTASLEATWSQYREAMGDLGDVLAGSAHDEPATTKVIYLIDAFASEDMDARSALCAAFYTAYQSYVAALAQSAVEDGAREPASDLVLQILPMELIYKPHELVIPTSEHMASLAREVYDRLPPAASQKAASTDAVSLVTTAPCVHLAPTVPKRVNFQLSADPPHDLLHEGSVLHLAYSFTADKHWLAVHWTDAAGMFADSVVLSMRGRSVTEIFEQVWGRTLSALDRKQIPWKVCITRATPRSYIPAWEAQCWHDIVGEKTKRKQVTSVTLLAVDLEPSVQFTPPTNSDGESGDATAGAGAFLAPVSTPQAGSTMTGGSVMTVSPTADSITAPPTPAPSDSTAAAPEKDAEGHLVDLEDETWSILLDRSKIPRRSAPDHVTTASVLACGQLIKRGDPASASQSHFPAIGADLLWTIQIRAAGAGIVEGNARHAEAMLREVVLSSSLRLANITAHLHPTRTIATMTDPSKYKFNHSMLRVKDPKASVKFYEHLGMSLVEQKDFPDNKFSLYFLAYDSPKATSHGNHWTDREGIIELTHNHGTENDANYKVANGNKEPGKGFGHVCISVDNIQAACKRISDAGYKFQKRLEDGRMRHIAFALDPDEYWVEVISQKDVAETEKETTTDLQTYKMNHTMIRIKDKDASLKFYQDVMGMQLLRTAENESNGFNLYFLGYGEGKGAGREGLLELTWNYGTEKEEGKVYHDGNSEPQGFGHICVSVDDLNKACERFEKEGVSWKTKLSDGRMRNVAFVLDPDGYWIEVIQNEKYGKPPGEY
Length1377
PositionKinase
OrganismRachicladosporium sp. CCFEE 5018
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium> unclassified Rachicladosporium.
Aromaticity0.06
Grand average of hydropathy-0.388
Instability index38.93
Isoelectric point5.13
Molecular weight148533.99
Publications









Function






Annotated function

Catalyzes the conversion of hemimercaptal, formed from
methylglyoxal and glutathione, to S-lactoylglutathione.



ECO:0000256	RuleBase:RU361179

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
lactoylglutathione lyase activity	GO:0004462	IEA:UniProtKB-UniRule
metal ion binding	GO:0046872	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13325
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     132.93|      25|      32|    1147|    1171|       1
---------------------------------------------------------------------------
 1147- 1171 (48.23/24.65)	DANYKVANGNKEPGKGFGHVCISVD
 1182- 1204 (38.96/18.73)	DAGYKFQK.RLEDGR.MRHIAFALD
 1300- 1323 (45.74/23.07)	EEGKVYHDGNSEP.QGFGHICVSVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1025.30|     263|     264|     366|     629|       2
---------------------------------------------------------------------------
   23-  255 (178.27/91.06)	..................................................................................VGGAEQADPRprghSI....ASSVGAThgyVGQHEDLFGDLGGDEVDeedfsffdepddmrvigsvavpaadadvamtehgGADDPLSPNAEplgASPRL.DVEEAEELSMqNTMMIASTATdATDNAITIDGGYApsggNGDSL..SFDTETPRP..HAATL.........DHR....P..LSLLTIK....EQ.................................LLPPPIPASAstdqphnTAAQKKGSfaPLAFGQRYN...TSAPSRLSLPSENGQHGVSSKSARPAPTSM
  260-  518 (382.99/208.23)	KQSDSTDeSSEADG..RSDTPVSSETSSSSASSPDMEIVMHQ..EAATGPHTSRKRKRS.ALLES.AVIGTnpSDWIARLPMFNQIA.........SD....HTYLQDL...RRKARDMTATACSVF...................................gGADQPARHKNE...HAQRLWDDFNGQDLVM.ISQIVAEQAI.TTTHSIVDDLQVL....KLDDI..PLDSALAST..AASTVLGILNGIVPATK....PSDLATLVMT....RE.................................LPTRPTPANA.......TAAKSSGQ..PRPPPPRHDaMITAGPDVQSLAIPYMRVTRASDTIELLPTAM
  519-  785 (337.79/179.80)	PFWDALG.LGPVSG..AKKVRYYCVAPKSDHLGDIVETFLHELSQAFEGSNLGQHRAVG.ATDES.VPVAR..WQWLLSVDCVASAAARDTR....SN....TASLEAT...WSQYREAMGDLGDVLAG...............sahdepattkviylidafaSEDMDARSALC...AA..FYTAYQSYVAAL.AQSAVEDGAR.EPASDLV..LQIL....PMELIykPHELVIPTSehMASLAREVYDRLPPAASqkaaSTDAVSLVTTapcvHL.................................APTVPKRVNF..............Q..LSADPP.HD.LLHEG.SVLHLAYSF..............TAD
  786-  947 (126.25/61.89)	KHWLAVH.WTDAAGmfADSV...VLSMRGRSVTEIFEQVWGRTLSALDRKQIPWKVCITrATPRSyIPA....WEAQCWHDIVGEKTKRKQV....TSvtllAVDLEPS.vqFTPPTNSDGESGDATAG....................................................................................................................................................agaflapvstpqagstmtggsvmtvsptadsitAPPTPAPSDS.......TAA.................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.10|      14|     150|    1132|    1145|       3
---------------------------------------------------------------------------
 1132- 1145 (28.22/19.12)	REGIIELTHNHGTE
 1285- 1298 (28.88/19.75)	REGLLELTWNYGTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.28|      16|      33|    1069|    1085|       4
---------------------------------------------------------------------------
 1069- 1084 (31.74/23.17)	DPSKYKFNHSMLRVKD
 1228- 1243 (31.55/16.84)	DLQTYKMNHTMIRIKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.12|      33|     157|    1087|    1121|       5
---------------------------------------------------------------------------
 1087- 1119 (62.04/44.21)	ASVKFYEH.LGMSLVEQKDFPDNKFSLYFLAYDS
 1246- 1279 (58.08/33.80)	ASLKFYQDvMGMQLLRTAENESNGFNLYFLGYGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.32|      20|     150|    1205|    1224|       6
---------------------------------------------------------------------------
 1205- 1224 (36.16/24.25)	PDEYWVEVISQKDVAETEKE
 1357- 1376 (40.16/27.76)	PDGYWIEVIQNEKYGKPPGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.33|      28|      32|     971|     999|       7
---------------------------------------------------------------------------
  971-  999 (43.44/34.21)	RSKIPRRSApDHVTTASVLACGQLIKRGD
 1005- 1032 (47.89/32.03)	QSHFPAIGA.DLLWTIQIRAAGAGIVEGN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13325 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DNAITIDGGYAPSGGNGDSLSFDTETPRPHAATLDHRPLSLLTIKEQLLPPPIPASASTDQPHNTAAQKKGSFAPLAFGQRYNTSAPSRLSLPSENGQHGVSSKSARPAPTSMRGILKQSDSTDESSEADGRSDTPVSSETSSSSASSPDMEIVMHQEAATGPHTSRKRKRSALLE
2) STMTGGSVMTVSPTADSITAPPTPAPSDSTAAAPEKDAEGH
3) TLVMTRELPTRPTPANATAAKSSGQPRPPPPRHDAMITA
4) TQPAGTLHDAPQASGSGGSGEDVGGAEQADPRPRGHSIASSVGATHGYVGQHEDLFGDLGGDEVDEEDFSFFDEPDDMRVIGSVAVPAADADVAMTEHGGADDPLSPNAEPLGASPRLDVEEAEELSMQNTMMIASTATDA
5) VQFTPPTNSDGESGDATAGAGAFLAPVSTPQA
143
916
452
1
883
318
956
490
141
914










Molecular Recognition Features






MoRF SequenceStartStop




1) DEVDEEDFSFFDE
62
74