<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13316

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSSDERSPKRQRRSYSPDSPETKHNSFVAQHPHTPPDSIHSQSMSPAWQAQTSTEQQSASFPMPTPPNTASLQGHTTATGARVEETVESERATPMAGAQGKPGGVDGDVEMADAEVGQGHRRTDHERLAEGSVPATGAPASVPKIGLFVLPTKPIVRQRPHPSSDLLGLYNLRDVQISVQRKDPITGEKVNRLRKSYEGKLKDLDLAGRNKATESNRILEGLVDADWDRVPEGADMTFWDLRFPWEVKLGSANHDALLGKLDKAFSLKPGRLPRSEHNQWSHLLGTDDTAAKAAPVASAVPAKAPLSKFMTKTAPAVIAGRSAPSSPQSAAGRTQRKGAKRRYDDTAFEGYDEDGYSTGGLDDRGAAKRRKRQDFTDDPGHAYSASVGSSKLGELDFSYTGVGGLRTPDASCTKGLMMGTHTGKMDGLKALNCA
Length434
PositionHead
OrganismRachicladosporium antarcticum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium.
Aromaticity0.05
Grand average of hydropathy-0.762
Instability index51.07
Isoelectric point8.83
Molecular weight46698.44
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13316
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.73|      23|      27|     332|     357|       1
---------------------------------------------------------------------------
  332-  357 (33.75/28.95)	GRTQRKGAKRRyDDTAFEgyDEDG..YS
  360-  384 (38.98/20.91)	GLDDRGAAKRR.KRQDFT..DDPGhaYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.78|      25|      28|      13|      37|       2
---------------------------------------------------------------------------
   13-   37 (49.18/25.18)	RSYSPD.SPETKHNSFVAQHPH.TPPD
   42-   68 (37.60/17.82)	QSMSPAwQAQTSTEQQSASFPMpTPPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.61|      17|      19|     143|     159|       3
---------------------------------------------------------------------------
  143-  159 (30.81/20.77)	PK.....IGLFVLPTKPIVRQR
  160-  181 (24.80/15.52)	PHpssdlLGLYNLRDVQISVQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.50|      18|      19|      95|     113|       4
---------------------------------------------------------------------------
   70-   91 (23.60/ 9.87)	ASLQGHTTAtgarVEETVESER
   96-  113 (31.90/15.43)	AGAQGKPGG....VDGDVEMAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.79|      18|      19|     187|     205|       5
---------------------------------------------------------------------------
  187-  205 (26.25/22.43)	G.EKVNRLRKSYEGkLKDLD
  208-  226 (25.54/16.36)	GrNKATESNRILEG.LVDAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.84|      21|      25|     249|     273|       6
---------------------------------------------------------------------------
  249-  269 (34.51/24.88)	LGSANHDALLGKLDKAFSLKP
  275-  295 (37.33/16.80)	SEHNQWSHLLGTDDTAAKAAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13316 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSSDERSPKRQRRSYSPDSPETKHNSFVAQHPHTPPDSIHSQSMSPAWQAQTSTEQQSASFPMPTPPNTASLQGHTTATGARVEETVESERATPMAGAQGKPGGVDGDVEMADAEVGQGHRRTDHERLAEGSVPATG
2) PAVIAGRSAPSSPQSAAGRTQRKGAKRRYDD
3) TGGLDDRGAAKRRKRQDFTDDPGHAYSASV
1
315
358
137
345
387










Molecular Recognition Features






MoRF SequenceStartStop




1) KFMTKTA
308
314