<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13315

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDNTDITDAVMADIQIPSASMMDSMDDLFGEPTNLVVQAPLLPGPPPPAELFTSLGQELAVVDSVGNVLVFTGTTGLGRMSIVPTDVGGETAGSPSDLDGVVGAYWLPQWPMDFRHATTGWGTTSTTLETLSTLDEKLSHAAFCQQDDKLLLVTHDLRRHLRVYTVTIDWNSTQGKDQHRQGTFRIVPSLQIAHIVSLEYIAPQHSEGTLLTSLRIIPPLLAFTEPSFTSYATVVAIYAQATYPADPTQQHESFTTICRWHLEELAQALHPSFAKLQKRAAPPVTLPNKKILRQQPDLVTAKVVLTMQSLNHDTLIAFGASDGTVEYRDRETWNIAAPAFGDTTTVMSLPQAGFEFSPSLEHSVHIACNTDCAYMIAGGVDQKLRCKPAALRYGWQAIDDGILDISGMHETAVACVAREHTLLTHHNNASALELFALLPTDLASEYRRHLFFDITRALTRAHDLCSLDEKTKQRMLLGDNYIIRCLGAQLSLVPSSDAQPGLGGQLAWLVLNAKHAHFALFSSCSGASPPGPATLHSLRGLAIWSLELFTASLAALYTVHSALASKPGEAPAAAVQLHVASSSSPLLHLLLCSYPRTLLRYLALALTRYFKLVASSLPSSPSLPIKTELLETISKIKTLPFRLEILAAPNGLLGEVDRAVGEAYTAAAVGPRERSEVELAMLLSPAPDLPAAMTGALESIWTKVVPKYLGEMDLGALYFFDATGLTIQSRGMTGTGAKRKIDVLTKLPITGETVRTCRRCSSIMDDFVTTAEGLREMGGFWKAIASRMCVCGGSWWVG
Length798
PositionTail
OrganismRachicladosporium antarcticum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium.
Aromaticity0.07
Grand average of hydropathy0.070
Instability index40.10
Isoelectric point5.81
Molecular weight86447.20
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13315
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     260.73|      53|      53|     618|     670|       1
---------------------------------------------------------------------------
  528-  563 (48.30/24.76)	..SPP.GPATLHSLRGLA.IWSLEL....FTASL...AA..............LYTVHSAL
  564-  616 (68.65/38.37)	ASKPGeAPAAAVQLHVASSSSPL.L....HLLLC...SYPRTLLRYLALALTRYFKLVASS
  618-  670 (82.81/47.84)	PSSPS.LPIKTELLETISKIKTLPF....RLEIL...AAPNGLLGEVDRAVGEAYTAAAVG
  671-  724 (60.97/33.23)	PRERS....EVELAMLLSPAPDLPAamtgALESIwtkVVPK.YLGEMD..LGALYFFDATG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     277.19|      85|     130|      73|     162|       2
---------------------------------------------------------------------------
   73-  162 (133.78/86.73)	GTTgLGRMSIVPtDVGGETAGSPSDLDGVVGAYWLPQWPMDFRHATTGWgtTSTTLETLSTLDEKLsHAAFCQ.QDDKLLLVTHDLRRHLR
  208-  293 (143.41/76.38)	GTL.LTSLRIIP.PLLAFTEPSFTSYATVVAIYAQATYPADPTQQHESF..TTICRWHLEELAQAL.HPSFAKlQKRAAPPVTLPNKKILR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.11|      11|     394|      50|      60|       7
---------------------------------------------------------------------------
   50-   60 (18.06/ 9.43)	ELFTSLGQELA
  433-  443 (18.06/ 9.44)	ELFALLPTDLA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13315 with Med16 domain of Kingdom Fungi
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