<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13311

Description Uncharacterized protein (Fragment)
SequenceMLTRPPVSSTSRPPLPTRSVTIGQQYPHTQQLRRPALPSRLSSVRSASGPSQHVNLDQYDSAWRNEVAQKNNASLGHVESGEDVTEEGRPRKKAKIESEEIMVSSPTDLDDEVHDIPPDEAHAFLPGAPMPLPPGPQPALRKPTPKNRLNHDPLRKAIGLQPPAIAIRLPAPKSIADFSPWSGTHPEDVLNETIIKGGYYDKPPNPSQNETNSARHSIWPNLSQKNNVALHTLSHLFTQVLEKRAAMGRITAPSSFKPPPRVTVTDTKREAWLKDLANLAIPLRRQSRTIPHGIRGKGLLEQCLAKEIPLSRAIWLAKCVGANELRAFRRKGVSGTAGAQGEAKWLRDWTVGVQQFFEGVVAECGKEDWRKQIDYAIKLTSSLYTEGLVEKEEFLDWVVRMLGSAEEKNLPLWAIM
Length416
PositionKinase
OrganismRachicladosporium sp. CCFEE 5018
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium> unclassified Rachicladosporium.
Aromaticity0.06
Grand average of hydropathy-0.582
Instability index53.24
Isoelectric point9.37
Molecular weight46213.09
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13311
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.60|      14|      21|       5|      22|       1
---------------------------------------------------------------------------
    5-   18 (27.46/15.45)	PPVSSTSRPPLPTR
   27-   40 (27.15/ 7.53)	PHTQQLRRPALPSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.79|      14|      22|     125|     138|       2
---------------------------------------------------------------------------
  125-  138 (29.95/13.19)	LPGAPMPLPPGPQP
  149-  162 (23.84/ 9.23)	LNHDPLRKAIGLQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.00|      14|      22|     332|     345|       3
---------------------------------------------------------------------------
  332-  345 (25.67/18.20)	GVS....GTAGAQGEAKW
  352-  369 (21.33/13.91)	GVQqffeGVVAECGKEDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.72|      29|     153|      50|      80|       4
---------------------------------------------------------------------------
   50-   80 (45.01/42.10)	PSQHVNLDQYDSAWRNeVAQKNNASLgHVES
  206-  234 (53.71/38.73)	PSQNETNSARHSIWPN.LSQKNNVAL.HTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      22.61|       7|      24|     281|     290|       6
---------------------------------------------------------------------------
  281-  290 ( 8.83/12.64)	IPLrrqSRTI
  308-  314 (13.78/ 6.73)	IPL...SRAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13311 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ETIIKGGYYDKPPNPSQNETNSARHSIWPN
2) MLTRPPVSSTSRPPLPTRSVTIGQQYPHTQQLRRPALPSRLSSVRSASGPSQHVNLDQYDSAWRNEVAQKNNASLGHVESGEDVTEEGRPRKKAKIESEEIMVSSPTDLDDEVHDIPPDEAHAFLPGAPMPLPPGPQPALRKPTPKNRLNHDPLRKA
192
1
221
157










Molecular Recognition Features






MoRF SequenceStartStop




1) LRRPAL
2) RSVTIGQ
32
18
37
24