<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13302

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDNNDLADAVMADIQIPSASMMDSMDDLFGEPTNLVVQAPLLLGPPAPAELVLRIAEMQRHGCCTAQCVSDASSNPIIALPGSEFVHLQYTSLGQELAVVDSVGNVQIFTGTTGLGRMSFAPTTGDSEAEGGRSGLDAVVGMYWLPQWPMDFRIPYVGPAVKTDGTWSSKLHYRDQQAPRLHHPVDGKTAFLYVTRNTLLTLCYQHDATTWGTASTTLEPLSTLDETLSHAAFCQQDNKLLLVTHDLRRHMRVYTITIDWNGTQGKDQYRSGTLRIAPSLLIGHSVSLEYVAPQHSEGTLLTSLQIILPVPIFAESSVPSYTTIVATFAQASYPSDATQQAQSFTTICRWHLEQVTQNLHPSFAKLQKRAAAAVTLPNKNTLRRQPDLVTAKVILTIQPMNHDTLIAFGASDGTVECRDRETWNIVAPTFGDTTTVTSLPQAGFEFTPSLEHSVHIMCNTDCAYMITLGVDQKLRCKPAALRYGWQAIDDGILDISGMHETAIACVAREHTLLTHHSNASALELFALLPPDLAPEQYRHLLFDITRALTRAHDLGSLDEKTKQRMLLGDNYIIRCLGAQLSLVSAPVAQPGIGAQLAWVVLTAKQAHFALFSSCSTTSPPDPATLHSLRGLAIWSLELFTASLATLFTVHSIFVAKPNETPATALASHIASSSSPLLHLVLCSYPRTLLRYLALALTRYFKLVASSLVNSPSLLIKTDLLETISKIKTLPFRLEILAAPDGLLGEIDRVVGEAYAVSTIGPRERAEAELTMLFSPAPDLPTSLNGAVKSIWTRILPKYTGEMDLGALYFYDTAGLILQSRERTGARAKRSVDVLTKLPIAEVFSLLALSALAASVSAQQSSPDLVSIISVLQTGLPSSILQEALTNSAGLSSEIASEFRVATPTWFTALPTDIQTYLVSAANSPSAFANATAGIASTLNGTAVMNSTSVAAAQSSILSSNSAEISSEVASASAAGTTSRGAGSGAASATSAGASSSSSAAGASMPTALYGMGLAGAVGLVGVLAL
Length1025
PositionTail
OrganismRachicladosporium antarcticum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium.
Aromaticity0.06
Grand average of hydropathy0.144
Instability index38.50
Isoelectric point5.69
Molecular weight109216.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13302
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     339.78|     111|     133|     181|     313|       1
---------------------------------------------------------------------------
  193-  313 (171.64/136.23)	YVT.RNTLLTLCYQHDATTWGTASTTL..EPLSTLDETLsHAAFCQ.QDNKLLLVT....HDLRRHMRVYTITIDWNgTQGKDQyrsGTLrIAPSLLIG.....HSVSLEYVAPQHSEGTLLTSlqiiLPVPIF
  321-  444 (168.14/88.96)	YTTiVATFAQASYPSDATQQAQSFTTIcrWHLEQVTQNL.HPSFAKlQKRAAAAVTlpnkNTLRRQPDLVTAKVILT.IQPMNH...DTL.IAFGASDGtvecrDRETWNIVAPTFGDTTTVTS....LPQAGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     219.20|      52|      95|     840|     896|       2
---------------------------------------------------------------------------
  840-  895 (71.17/44.23)	.....AE...VFSLLALSAL..AASVSAQQSSPDlvsiiSVLQTGLPSSILQEALTNSAGLSSEIA
  896-  928 (43.49/18.87)	SefrvA.........................TP......TWF.TALPTDI.QTYLVSAANSPSAFA
  932-  969 (45.38/20.03)	.....AG...IASTLNGTAVmnSTSVAAAQSS.................ILS...SNSAEISSEVA
  970- 1019 (59.15/28.41)	S....ASaagTTSRGAGSGA..ASATSAGASSSS.....SAAGASMPTALYGMGLAGAVGL.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.80|      16|      33|     662|     677|       5
---------------------------------------------------------------------------
  662-  677 (27.64/15.66)	ATALASH...IASS..SSPLL
  693-  713 (18.16/ 7.65)	ALALTRYfklVASSlvNSPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.68|      32|      35|     735|     769|       8
---------------------------------------------------------------------------
  735-  769 (43.67/29.95)	IL..AAPDgLLGEIDRVVGEAYavSTIGPRERAEAEL
  771-  804 (53.00/26.77)	MLfsPAPD.LPTSLNGAVKSIW..TRILPKYTGEMDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.34|      52|     438|      52|     117|       9
---------------------------------------------------------------------------
   52-  117 (84.12/68.32)	VLRIAEMQRHG.CCTAQ......CVSDASSNPIIALPGSEFVHLQYTSLgqelavvdsvgnvqIFTGTTGLGR
  492-  550 (80.22/44.15)	ILDISGMHETAiACVARehtlltHHSNASALELFALLPPDLAPEQYRHL..............LFDITRALTR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13302 with Med16 domain of Kingdom Fungi
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