<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13298

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDILKQCTTNVHELRGLPDIHVALYEREASSLYRRNDEGISAMLTQLRASGVHCTLSHGRSKGATGAEVPVDAMQLCLFGSCDPSLAASIPSLGFTLYLEGPLGDTAEAELLNGATVEEEVLRAIEATITHDLWQTQRGTKVGHCTWLMSDLLQNSGPIVRLDLAWSDVDAHIVIASVTSSTDKRYHPVCAADSASSPETDVMLAPGGTQAVLRFVDKTVTQPVQSEDWQFAVREALALGGIDIEADADWIEVMTRDLELMVWPVALIFAQNHADELVLSSGVQGSEPLNGAPGDNALLYNDLLSDAEQWFNDTIVRQRGPRTDHDLDDDVALHAVYDASGNAGGVFDFLSPQMVQRPETHAAGLLYPTPPDGMASFQQSQQTPNVTSTPVTQLAGLLPDGPQASGSGANGEDVGGPEHVDTRPRGPSIASSVGATHGYAGHHEDLFGDLGGDEVDEEDFSFFDEPDDMRVMGSEALPVKDGDVLMSEHRDDDDRLSPDAGLLGTGSAFEVEEPKGSPLQDTMVIASVAAHDTDTAMTIDVGHAPGGGNGESLSSDTETPRPHAVILDHRPLSPLTIKEQLLPPPVPASASTDQLHNTAAQKKGSFAPLEFGQRQKNNASARLSLLSDSGQCGSFSKSARPASMSMRGMLRQSDSTDESSEADGRSDTPVSSEISSSSASSPDMETVMHQEAANGPQTSRKRKRSALLESAVTGTNPLDWVARLPMFNQTASDHKYLQDLRRKAQDMTATACSAFGGVDQLVRHKRKHPQGLWDDYNSQDLVMISQVLAEQAITTTHSIVDDLQVLRINGIPPDSASASTAADTVLGLLNSIVPTTKPSDLTTLVMTRELPSRPTPVTTTTAKVPGQPRPPPPRHDATSTTGPDVQSLTIPYMCVTRAGDTLELLPTAMPFWDALGLGPVSRAKNLRYYCVAPNSDHLGDSIEAFMHDLSQVYEGCNLGLHRAVGATDESMPDKRQQWLFNVDCSMAAHSRNASLQAMWPQYHEVMGDLGKALAGCAHEEAATTKVIYLVDPFSNRAADPRPVLCAAFNIAYKQYVDLLAHSAGADGINKSASDVVLQILPVDLILKPHELVILTGAHMASLAREVYDRLPSAANQKASQGDAPSIITTAPCVHLAPTIPKRVNFQLLAEPPHDLLHEGSVLHLAYSFTANKHWLTVHWTDAAGMFADSVVLPMRGRSVAEVFEQVWSRTLSALDRKQIPWKVCITRAMPRSHIPAWEAQCWHDIAGEKTRRKQVTSVTFLAVDLEPAVQFTPPVSSIGDSGDATAGAGAFLTPVSTPQAGGTMTGASLMTVSPTADSITAPPTPAPSDGPAAAPEKDAEGHLVDLEDETWSLLLDRSKIPRRSTPNHITTASILACGQLIKRGNPTSAAQSHFPAIAADLLWTIQIRAAGAGIVEGNARHAEAMLREVLGTWRGLGCLAKLRGLQLAESLNDLVPIHVVGAVQAARALEWMP
Length1473
PositionKinase
OrganismRachicladosporium antarcticum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium.
Aromaticity0.05
Grand average of hydropathy-0.231
Instability index43.14
Isoelectric point4.99
Molecular weight157709.27
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13298
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     271.24|      83|     185|      99|     211|       1
---------------------------------------------------------------------------
  101-  189 (132.53/107.10)	GPLGDTAEAELLNGATVEEEVLRAIEATItHDLWQTQRGTKVG.HCTWLMSDllqNSGPIVRLDlaW.SDVDAHIVIASVTSSTD...KRYHPV
  918- 1005 (138.70/78.96)	GPVSRAKNLRYYCVAPNSDHLGDSIEAFM.HDLSQVYEGCNLGlHRAVGATD...ESMPDKRQQ..WlFNVDCSMAAHSRNASLQamwPQYHEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.84|      20|      29|     352|     372|       2
---------------------------------------------------------------------------
  352-  372 (35.26/26.85)	PQMVQRPETHAAGLLyPTPPD
  384-  403 (37.58/22.94)	PNVTSTPVTQLAGLL.PDGPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.82|      54|     185|    1111|    1164|       3
---------------------------------------------------------------------------
  545-  609 (82.05/37.63)	PGGGNGESLSSDTETPRPHAVILDHRPLSPLTIKEQLLPPPvPasasTDQLHntaaqkKGSFAPL
 1111- 1164 (95.77/45.00)	PSAANQKASQGDAPSIITTAPCVHLAPTIPKRVNFQLLAEP.P....HDLLH......EGSVLHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.50|      24|     185|     283|     307|       4
---------------------------------------------------------------------------
  283-  307 (40.08/30.53)	VQGSEPLNGAPGDnALLY.....NDLLS.DA
  471-  500 (33.42/19.59)	VMGSEALPVKDGD.VLMSehrddDDRLSpDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.51|      30|      37|     802|     838|       5
---------------------------------------------------------------------------
  802-  838 (40.42/34.95)	DLQVL...RinGIPPDSASASTAADTVLGLlnsivPTTKP
  840-  872 (50.10/26.23)	DLTTLvmtR..ELPSRPTPVTTTTAKVPGQ.....PRPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.55|      44|     551|     633|     717|       6
---------------------------------------------------------------------------
  654-  698 (70.15/70.11)	DSTDESSEAdGRSDTPVSSEISSSSASSPDMETVM.HQEAANGPQT
 1280- 1324 (68.40/39.84)	DSGDATAGA.GAFLTPVSTPQAGGTMTGASLMTVSpTADSITAPPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.08|      37|     552|      34|      74|       7
---------------------------------------------------------------------------
   34-   74 (56.65/43.25)	RRNDEGISAMLTQLRASGvHCtlsHGRSKGATGAEVPVDAM
  613-  649 (65.43/38.22)	QRQKNNASARLSLLSDSG.QC...GSFSKSARPASMSMRGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.93|      47|     207|     191|     247|       8
---------------------------------------------------------------------------
  196-  247 (68.71/59.60)	SSPE...TDVMLAPGgtQAVLRFVDKTVTQ...PVQSED..WQFAVREALAlgGIdIEAD
 1364- 1418 (68.22/34.01)	STPNhitTASILACG..QLIKRGNPTSAAQshfPAIAADllWTIQIRAAGA..GI.VEGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.84|      62|     290|     731|     800|       9
---------------------------------------------------------------------------
  736-  800 (98.27/73.90)	YLQD.LRRKAQDMTATACSAFGGVDQLVRHKRKHPQGLwDDYN..SQDLVMisQVLAEQAITTTHSIV
 1028- 1092 (96.56/52.14)	YLVDpFSNRAADPRPVLCAAFNIAYKQYVDLLAHSAGA.DGINksASDVVL..QILPVDLILKPHELV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13298 with Med13 domain of Kingdom Fungi
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