<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13292

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceMDILKQCTTNVQELRGLPDIHVALYERENSKIYRKNEDDIPALLAQLRTSEVHCTLSNGTSTGAPEAKISVDSMQLCLFGQCDSSLTALILSLGFTLYLEGSLGDTAEAELLNGATVEEEALRAIEASIAYDLWQTRRGTKVGHCTWLMSDSLENSGPIVRLSLAWNDVDAHIVIVSVMSSTDKRYYPVCAASSASSPEIDVTLAPGGRQAVLKFVGNTLSPAVPSENWQFAVREALALEGIEIGLEADWIEVMTKDSGAMMWPAALTFTQSYADEVVLSSDVQGLELSDGVPGDNALLYNDPLCDAEQWFNDAIMRERRPLNDNHPDDDDALHTVYDASGNAGAAFDFLSPQMMQRPETHAVGLLYPTPPDGMASFQQSQQTPNVTSTPVTQPAGTLHDAPQASGSGGRGEDVGGAEQADPRPRGHSIASSVGATHGYVGQHEDLFGDLGGDEVDEEDFSFFDEPDDMRVIGSVAVPAADADVAMTEHGGADDPLSPNAEPLGASPRLDVEEAEELSMQNTMMIASTATDATDNAITIDGGYAPSGGNGESLSFDTETPRPHTAILDHRPLSPLTVKEQLLPPPIPASASTDQPHNTAAQKKGSFAPLAFGQRYNTSAPARLSLPSENGQHGVSSKSARPASTSMRGILKQSDSTDESSEADGRSDTPVSSETSSSSASSPDMEIVMHQEAASGPQTSRKRKRSALLESAVIGTNPSDWIARLPMFNQIASDHTYLQDLRRKARDMTATACSVFGGADQPARHKSEHAQRLWDDFNGQDLVMISQILAEQAITTTHSIVDDLQVLKLDNISLDSAFASTAANTVLGILHGIVPATKPSDLATLAMTREVPTRPTPANATAAKTPGQPRPPPPRHDAITTAGPDVQSLTIPYMRVTRSGDTLELLPTAMPFWDALGLGPVAKAKNVRYYCVAPKSDHLGDPIEAFMQNLGQAYEGCNLGQHRAVGATDESVPAAMWQWLLSVDCIANAAARNTRSKTASLEATWPQYRDAMGDLGDVLAGSAHDEHATTKVIYLIDAFSSEDMDARSALCAAFYTAYQSYVAALAQSAVEDGAREPASDLVLQILPMELIYKPHELVIPTSEHMASLAREVYDRLPPAASQKAASTDAVSLVTTAPCVHLAPTVPKRVNFQLLADPPHDLLHEGSVLHLAYSFTADKHWLAVHWTDAAGMFADSVVLSMRGRSVTEIFEQVW
Length1212
PositionKinase
OrganismRachicladosporium sp. CCFEE 5018
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium> unclassified Rachicladosporium.
Aromaticity0.06
Grand average of hydropathy-0.268
Instability index43.38
Isoelectric point4.65
Molecular weight129888.32
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13292
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1025.81|     256|     261|     360|     620|       1
---------------------------------------------------------------------------
  360-  616 (410.60/224.44)	..................THAVGLLYPTP.P..DGMASFQQSQQTPNVTSTPVTQPAGTLHDAPQASGSGGRGEDVGGAEQADPRPRGHSIASSVGAT..........................HGYVGQHEDLFGD..LGGDEVDE.EDFSFFDE.PDDMRVIGSV.AVPAAD.ADV..AM.....TEHGGADDPLSPNAEPLGASPRL.DVEEAEELSMQ.........NTMM....IASTATDATD......NAITIDGGYAPSGGNgESLSFDTETPRPHTAILDHRP..LSPLTVKEQLLPPPIPASAstdqPHNTAAQKKGSFAPLAFGQRYN
  617-  876 (314.39/161.90)	TSAP....arlslpsengQHGVSSKSARP.......ASTSMRGILKQSDSTDESSEADGRSDTPVSSETSS.....SSASSPDMEIVMHQEAAS.GPQ..........................TSRKRKRSALLESavIGTNPSDWiARLPMFNQiASDHTYLQDL.RRKARDmTAT..AC.....SVFGGADQPARHKSE...HAQRLwDDFNGQDLVMI.........SQILaeqaITTTHSIVDDlqvlklDNISLDSAFASTAAN.......TVLGILHGIVPATKPsdLATLAMTREVPTRPTPANA.......TAAKTPGQ..PRPPPPRHD
  880- 1171 (300.82/154.56)	TAGPdvqsltipymrvtrSGDTLELLPTAmPfwDAL.GLGPVAKAKNVRYYCVAPKSDHLGD.PIEAFMQNLGQAYEGCNLGQHRAVG.ATDESVPAAmwqwllsvdcianaaarntrsktaslEATWPQYRDAMGD..LG....DV.LAGSAHDE.HATTKVIYLIdAFSSED.MDArsALcaafyTAYQSYVAALAQSAVEDGA......REPASDLVLQilpmeliykPHEL....VIPTSEHMAS......LAREVYDRLPPAASQ.KAASTDAVSLVTTAPCVHLAP..TVPKRVNFQLLADP.........PHDL..LHEGSVLHLAY.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.96|      18|     915|     260|     280|       2
---------------------------------------------------------------------------
  260-  280 (29.21/26.18)	AMMWPAAltfTQSYADEVVLS
 1181- 1198 (33.75/20.86)	AVHWTDA...AGMFADSVVLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.28|      12|     829|     133|     155|       4
---------------------------------------------------------------------------
  133-  155 (17.45/33.11)	LWQtrrgtkvghctWLMS.DSLEN
  975-  987 (22.83/11.87)	MWQ...........WLLSvDCIAN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13292 with Med13 domain of Kingdom Fungi
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