<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13287

Description Uncharacterized protein
SequenceMLTRPPVSSTSRPPLPTRSVTIGQQYPHTQQLRRPALPSRLSSVRSASGPSQHVNLDQYDSAWRNEVARKDNASLGHVESSDDGAEEGRPRKKAKIEPEEIMVSSPVNLDDEAQDITPDEAHVLQPGDPMPLPPRPQPPPRKSTPKNQLNHDPLRKATGLQPPPIATRLPAPKSIADFSPWSGTHPEDVLNETIIKGGYYDKPPNPSQNETNSARHSIWPNLSQKNNVALHTLSHLFTQVLEKRAAMGRITAPSSFKPPPRVTVTDTKREAWLKDLANLAIPLRRQSRTIPHGIRGKGLLEQCLAKEIPLTRAIWLAKCVGANELRAFRRKGVSGVAGAQGEAKWLRDWTVGVQQFFEGVVAECGKEDWREKIDYAIKLTSSLYTEGLVEKEKYLDWVVRMFGSAEEKNLPLWAIMVQIYWKELLKSGCRGRKLATAILEHLHGMEAQTSTAYVALKERLRKLIAILAVTEQGCLVVPATWEKYKHLLSSVERALPVHLRDAVTSVIERNERLAAPMTRTSRNTRSPMLRLVDLLDGVDLSLNIVKLASQCLALLPDIKGLVSGILSWSSTSFRSGDARVYIAAGVLEQLYKAGYDIDNAISAYLQTDAELTPAETKNVGLVIAHLVHRDCFAVGIYLQWLIVNGVASSRSSPSPAALVLTALPHEKIPRHLASLRDALLARSGLVAHESAAISNVYDGIDLDSQEGSTKYIDRSGKLQSLSMSARSTLSTALVQRIASQAKDDGVTNANFCLLRDVFEQACQHLAISALIGATTATDDFAALASATDTLATHALALAALGQLSPLFHALYNQHVQLRTHREFDRTFLLALLRLAVRLPGLDPSVATLLKNDLVLCDQRSSAAACSPASDNLVSIIAERLDSDDQIDAVFASGNTMDEATFNRVFLRVMARADGVENGGKTAQSRLCGWVEQLRVIDAPELEKVGKEYVTSVMSKSDGLVAISAGVVALLASGCLTIDSIFPTSGAIDQLSVALSWLRFLAEPLTLAAFTTSELYAFELQRQQFCEEEHVRLAQLVCRAADQDTSAMESSWMINLCLRLNVASKGEHSLLDDRRLPGSVSKAILERRRPIARILNPCEIIHAADALNIAVSMKWLQAQALAPISSNGDSEIRHALLEAFRSDSVVWPQLLSAASPEMSRSIHESAVDLVLLAASSGSQDDDAATAKMTERCCMLMDLTYPAVCTHDNTHVFTMVSDRIKVITTALGESDKAPQRQLLANLQTLLHVLALYSSSISESSDTQGRTQLAAILLSLLASPRLQHGSLLPQDTMAYIHDVAALYIDALPPAELSTLVKALPVPTAKSHYLASLLPDLRPQDPNLALATRVPVPRPSRALPSSAVARPPAPVRPRPPFPQPSSAAPLEHMQPRHATQQSQMPSEVRHAPFQVKRWEVLPDATPTVGENDCAIGLGMFGARKV
Length1437
PositionKinase
OrganismRachicladosporium antarcticum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium.
Aromaticity0.05
Grand average of hydropathy-0.143
Instability index50.62
Isoelectric point7.41
Molecular weight156877.79
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13287
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     130.46|      19|      23|    1338|    1356|       1
---------------------------------------------------------------------------
    5-   23 (32.05/13.28)	PPVSSTSRPPLPTRSVTIG
  131-  145 (27.40/10.21)	.PLPPRPQPP.PRKST..P
 1338- 1356 (31.59/12.98)	PNLALATRVPVPRPSRALP
 1363- 1381 (39.43/18.14)	PPAPVRPRPPFPQPSSAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.79|      22|      25|     345|     369|       2
---------------------------------------------------------------------------
  315-  343 (25.70/ 6.29)	WLAK.CVGANELraFRrkgvsGVAGAQGEA
  345-  367 (36.09/26.13)	WLRDwTVGVQQF..FE.....GVVAECGKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.82|      22|      25|     893|     916|       3
---------------------------------------------------------------------------
  893-  914 (39.83/32.71)	GNTMDEATFNRV.FLR.................VMARADG
  919-  958 (25.99/12.02)	GKTAQSRLCGWVeQLRvidapelekvgkeyvtsVMSKSDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.23|      25|      27|     747|     772|       4
---------------------------------------------------------------------------
  747-  772 (41.08/35.77)	TNA..NFCLLRDVFEQACQH.LAISALiG
  774-  801 (31.15/20.57)	TTAtdDFAALASATDTLATHaLALAAL.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.48|      21|      25|      82|     102|       5
---------------------------------------------------------------------------
   82-  102 (36.23/26.45)	DDGAEEGRPRKKAKIEPEEIM
  110-  130 (38.26/28.43)	DDEAQDITPDEAHVLQPGDPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.07|      27|      27|    1228|    1254|       6
---------------------------------------------------------------------------
 1228- 1254 (44.41/27.44)	SDKAPQRQLLANLQTLLHVLALYSSSI
 1258- 1284 (44.65/27.63)	SDTQGRTQLAAILLSLLASPRLQHGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.97|      17|      18|    1137|    1154|       8
---------------------------------------------------------------------------
 1137- 1154 (24.76/23.11)	EAFRS..DSVVwPQLLSAAS
 1156- 1174 (23.21/13.73)	EMSRSihESAV.DLVLLAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.06|      17|     115|     986|    1004|       9
---------------------------------------------------------------------------
  986- 1004 (25.96/17.06)	AIDQLSVALS..WLRflAEPL
 1102- 1120 (25.10/10.63)	AADALNIAVSmkWLQ..AQAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.91|       9|      26|     430|     439|      11
---------------------------------------------------------------------------
  430-  439 (12.11/10.82)	RGRKLaTAIL
  459-  467 (15.80/ 8.56)	RLRKL.IAIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.88|      13|      19|    1285|    1301|      12
---------------------------------------------------------------------------
 1285- 1299 (17.66/17.59)	LPQDTMAYIhdVAAL
 1304- 1316 (21.22/ 6.02)	LPPAELSTL..VKAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13287 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ETIIKGGYYDKPPNPSQNETNSARHSIWPNL
2) MLTRPPVSSTSRPPLPTRSVTIGQQYPHTQQLRRPALPSRLSSVRSASGPSQHVNLDQYDSAWRNEVARKDNASLGHVESSDDGAEEGRPRKKAKIEPEEIMVSSPVNLDDEAQDITPDEAHVLQPGDPMPLPPRPQPPPRKSTPKNQLNHDPLRKATGLQPPPIATRLPAPKSIADFSPWSGTHPEDVL
3) PSRALPSSAVARPPAPVRPRPPFPQPSSAAPLEHMQPRHATQQSQMPSEVRHAPFQVKRWEVLPDATPTVGENDCAIG
192
1
1351
222
190
1428










Molecular Recognition Features






MoRF SequenceStartStop




1) LRRPAL
2) RKKAKIEP
32
91
37
98