<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13283

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDILKQCTTNVQELRGLPDIHVALYERENSKIHRNNEDDIPALLAQLRTSEVHCTLSNGTSTGAPEAKVSVDSMQLCLFGRCDSSLTALILSLGFTLYLEGSLGDTAEVELLNGATVEEEVLRAIEAGIAYDLWQTRRGTKVGHCTWLMSDSLGNSGPIVRLSLAWSDVDAHIVIVSVTSSTGKRYYPVCAASSASSPEIDVTLAPGGRQAVLKFVDNTLSPAVPSEDWQFAVREALALEGIEIGLEADWIEVMTTDSGAMMWPAALTFTQSYADEVVLSSDVQGLELSDGVPGDNALLYNDALCDAEQWFNDAIIRERRPLNDNHPDDDVALHAVYDASGNAGAAFDLLSPQMTQRPETHAVGLLYPTPPDGMASFQQSQQTPNVTSTPVTQPAGTLHDAPQAPGSGGSGEDVDGAEQADPRPRGHSIASSVGATHGYVGQHEDLFGDLGGDEVDEEDFSFFDEPDDMRVIGSVAVPAADADVAMTEHGGADDPLSPNAGPLGASPRLDVEEAEESSMQNTMMIASSATDATDNAITIDGGYAPSGGNGDSLSFDTETPRPHAAILDHRPLSLLTSKEQLLPPPIPASASTDQPHNTAAQKKGSFAPLAFGQRYNTSAPARLSLPSENGQHAVSSKSARPASTSMRGILKQSDSTDESSEADGRSDTPVSSETSSSSASSPNMEIVMHQEAATGLHTSRKRKRSALLESAVIGTNPSNWIARLPMFNQIASDHTYLQDLRRKARDMTATACSVFGGADQPARHKSDYAQRLWDDFNGQDLVMISQILAEQAITTTHSIVDDLQILKLDDIPLDSALASTAASTILGILNGIVPATKPSVLATLVMTCELPTRPTPANATAAKTPGQPRPPPPRHDAMTTAGPDVQSLTIPYMRVTRASDTIELLPTAMPFWDALGLGPVSGAKKVRYYCVAPRSDHLGDIVETFMHELSQAFEGSNLGQHRAVGATDESVPAARWQWLLSVDCVASAAARDTRSNTASLEATWSQYREAMGDLGDVLAGSAHDEPATTKVIYLIDAFASEDMDARPALCAAFYTAYQSYVAALAQSAVEDGAREPASDLVLQILPMELIYKPHELVIPTSEHMASLAREVYDRLPPAASQKAASTDAVSLVTTAPCVHLAPTVPKRVNFQLLADPPHDLLHEGSVLHLAYSFTADKYWLVVHWTDAAGMFADSVVLSMRGRSVTEIFEQVWGRTLSALDRKQIPWKVCITRATPRSYIPAWEAQCWHDIVGEKTKRKQVTSVTLLAVDLEPSVQFTPPTNSDGESGDATAGAGAFLTPVSTPQAGSTMTGGSVMTASPTADSITAPPTPAPSDSTAAAPEKDAEGHLVDLEDETWSLLLDRSKTPRRSAPDHVTTASVLACGQLIKRGDPASASQSHFPAIGADLLWTIQIRAAGAGIVEGNARHAEAMLREVLGTWRGLGCLAKLRGLHLGKGLDGLVPIHVVGAVEAARALGGMPR
Length1479
PositionKinase
OrganismRachicladosporium antarcticum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium.
Aromaticity0.05
Grand average of hydropathy-0.202
Instability index42.77
Isoelectric point4.76
Molecular weight157313.12
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP13283
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     271.07|      62|     213|     122|     183|       1
---------------------------------------------------------------------------
  122-  183 (106.07/64.82)	LRAI.....EAGIAYDL...WQTRRGTKVGHCTWLMSD...SLGNSGP...IVRLSLAWSDVDAHIVIVSVTSSTG
  333-  396 (86.03/50.97)	LHAVydasgNAGAAFDLlspQMTQRPET..HAVGL.......LYPTPP...DGMASFQQSQQTPNVTSTPVTQPAG
 1241- 1306 (78.97/46.09)	..AW.....EAQCWHDI.vgEKTKR.KQVTSVTLLAVDlepSVQFTPPtnsDGESGDATAGAGAFLTPVS.TPQAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     790.40|     256|     333|     467|     747|       2
---------------------------------------------------------------------------
  467-  747 (390.08/244.61)	DDMRVI...GSVAVPA.ADADVA........................MTEHGGADDPLSPNAGPLGASprLDVEEAEESSMQNTMmiassATDATDNAITIDGGYAPSGgnGDSLSFDTETPRPHAAILdhrpLSLLTSKEqlLPP.PIPASAS....TDQPHNTAAQKKGS.FAPLAFGQRYNTSAP.............................AR...LSLPSENGQHAVSSKSARPASTSMRG.....I...................LKQSDSTDESSEA..................DGRSDTPvSSETSSS..SASSPNMEIVM....HQEAAT........GLHTSRKRKRSALleSAVIGTNPSNWIARLpmfNQIASDhtylQDLRRKARDM
  750- 1080 (290.65/142.63)	TACSVF...GGADQPArHKSDYAqrlwddfngqdlvmisqilaeqaiTTTHSIVDD..............LQILKLDDIPLDSAL.....ASTAASTILGILNGIVPAT...............KPSVL....ATLVMTCE..LPTrPTPANA...........TAAKTPGQpRPPPPRHDAMTTAGPdvqsltipymrvtrasdtiellptampfwDA...LGLGPVSGAKKVRYYCVAPRSDHLGD.....IvetfmhelsqafegsnlgqHRAVGATDESVPAarwqwllsvdcvasaaarDTRSNTA.SLEATWSqyREAMGDLGDVLagsaHDEPATtkviylidAFASEDMDARPAL..CAAFYTAYQSYVAAL...AQSAVE....DGAREPASDL
 1087- 1210 (109.66/46.71)	..MELIykpHELVIPT.SEHMAS........................LARE..VYDRLPPAASQKAAS...........................................TDAVSLVTTAPCVH..................LAP.TVPKRVNfqllADPPHDL..LHEGS.VLHLA....YSFTAD.............................KYwlvVHWTDAAGMFA...DS...VVLSMRGrsvteI...................FEQ...............................................................................................................................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13283 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DNAITIDGGYAPSGGNGDSLSFDTETPRPHAAILDHRPLSLLTSKEQLLPPPIPASASTDQPHNTAAQKKGSFAPLAFGQ
2) RPETHAVGLLYPTPPDGMASFQQSQQTPNVTSTPVTQPAGTLHDAPQAPGSGGSGEDVDGAEQADPRPRGHSIASSVGATHGYVGQHEDLFGDLGGDEVDEEDFSFFDEPDDMRVIGSVAVPAADADVAMTEHGGADDPLSPNAGPLGASPRLDVEEAEESSMQNTMMIASSATDA
3) RPTPANATAAKTPGQPRPPPPRHDAMTTAGP
4) VQFTPPTNSDGESGDATAGAGAFLTPVSTPQAGSTMTGGSVMTASPTADSITAPPTPAPSDSTAAAPEKDAEGHL
5) YNTSAPARLSLPSENGQHAVSSKSARPASTSMRGILKQSDSTDESSEADGRSDTPVSSETSSSSASSPNMEIVMHQEAATGLHTSRK
534
357
853
1274
615
613
532
883
1348
701










Molecular Recognition Features






MoRF SequenceStartStop




NANANA