<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13279

Description Uncharacterized protein
SequenceMLTRPLVSSTSRPPLPTRSVTIGQQYPHTQQLRRPAPPSRLSSVRSASGPSQHVDLDEYDSAWRNEVAQKNNASLGHVESGEDVAEEGRPRKKAKIESEAIMVSSPTDLNDEVHDIPPDDAHALLPGAPMPLPPGPQPALRKPTPKKQLNHDPLRKATGLQPPAIAIRLPAPKSIADFSPWSGTHPEDVLNETIIKGGYYDKPPNPSQNETNSARHSIWPNLSQKNNVALHTLSHLFTQVLEKRAAMGRITAPSSFKPPPRVTVTDTKREAWLKDLANLAIPLRRQSRTIPHGIRGKGLLEQCLAKEIPLSRAIWLAKCVGANELRAFRRKGVSGTAGAQGEAKWLRDWTVGVQQFFEGVVAECGKEDWRKQIDYAIKLTSSLYTEGLVEKVEYLDWVVRMLGSAEEKNLPLWAIMVQIYWKELVKLGYRGRRLATAILEHLHGLEAQTSTACVALKERLRKLIAILAVTEQGCLVVPATWEKYKHLLSPVERAIPVHLRVAVTSVTRRNERLAAPMTRTSRNTRSRMLRLVDLLDAVDLRLDIVKLASQCLALLPDINGLVSGLLSWTSSSFRSGDARVYVAAGVLEQLYKAGYDIDNAISAYLQTDVEITPAETNNVGLVVAQLVQRDCFAVGVYLQWLIVNGAASTRSSPTPTASILTALPREKIPRHLASLRDALLARYGLVAHESAAICSMFDGITLELQEGRTKFIDRSGMLQSLSTSARSTLSTSLVQRIALQAKHDGITNANFCLLRDVFEQACQHLAISALIVATTATDDFAALASATDTLATYALALAALGQLSPLFHALYNQHVQLRTHRDFDRTFLLALLRLAVRLPGLDPSVAILLKNDLILCDQRSSAAACSPASDNLVSIIAEQLDNDDQIDAVFASGNTMDEATFNRVFLRVMARADGVGNDGKTAQSRLCGWVEQLRVIDAPELEKLGKEYVNLVMSKGDLLVAIPAGVLALVASGCLTIDSIFPTSGACDQPSVALSWLRFLAEPLILGTFTTSELYAFELQRQQFCDEEHVKVIELLCRVADLDIPATETTWVMNLSLRLNVASKGEQSLLDDRRLPGSVSKTILQCKRPVARILDLCEIIHTADALNIAVTINWLQAQALTPGSSNGNGEIRHALLEAFRSDSVVWPQLLSAAPPEMLKSIHDSAVDLVLLAASSGSQDNDAATAKMTERCCMLMDLTYPAVCTHDNTHVLTTVSDRIKVITTALGESDIASQHQLVANLQTLLHVLALYSSSPSESSDTQARVRVSTILQSLLARPLQQQGSPLPQDTMECIHDVAALYIDALSPAELSALLKALPVPAAKSHYLASLLPDSRPQDANLAVATRVPASRPSRALPPSAAARPPAPVRPRPPFPQSGSAVPLPQPGSAVPLEIMPPRQATQQVPIPSEVKYAPFQVKRWEVLPDATPTVGENDCAIGLGMFGARKV
Length1446
PositionKinase
OrganismRachicladosporium antarcticum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Cladosporiales> Cladosporiaceae> Rachicladosporium.
Aromaticity0.05
Grand average of hydropathy-0.073
Instability index50.77
Isoelectric point7.56
Molecular weight157497.07
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP13279
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.51|      26|      27|    1331|    1357|       1
---------------------------------------------------------------------------
  135-  163 (28.61/12.58)	....GPQPAL.RKPTPKkqlnhdPLRK.ATGLQPP
 1331- 1357 (42.33/27.43)	P.DSRPQDANlAVATRV......PASR.PSRALPP
 1369- 1396 (42.57/23.13)	PrPPFPQSGS.AVPLPQ......PGSAvPLEIMPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.92|      22|      28|     313|     340|       2
---------------------------------------------------------------------------
  313-  338 (29.69/35.67)	AIWLAK.CVGANELraFrrKGVSGTAG
  343-  365 (36.24/19.59)	AKWLRDwTVGVQQF..F..EGVVAECG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.34|      14|      24|       5|      20|       4
---------------------------------------------------------------------------
    5-   18 (26.22/ 9.47)	PLVSSTSRPPLPTR
   27-   40 (27.12/11.98)	PHTQQLRRPAPPSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.83|      23|      27|     887|     912|       5
---------------------------------------------------------------------------
  887-  909 (40.17/29.37)	DAVFASGNTMDEATFNRV.FLRVM
  913-  936 (37.66/19.12)	DGVGNDGKTAQSRLCGWVeQLRVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.36|      16|      28|     839|     858|       7
---------------------------------------------------------------------------
  839-  858 (24.27/24.62)	PGLDPSVAIL...LKNDlilcDQ
  867-  885 (24.09/12.96)	PASDNLVSIIaeqLDND....DQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.70|      23|      28|     747|     773|       9
---------------------------------------------------------------------------
  747-  773 (34.64/37.59)	TNA.NFCLLrdvfEQACQHLAISALIVA
  775-  798 (32.06/22.23)	TATdDFAAL....ASATDTLATYALALA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.15|      17|      23|     471|     493|      10
---------------------------------------------------------------------------
  453-  469 (25.70/15.49)	CV...ALKERLRKLIAILAV
  474-  493 (25.45/19.06)	CLvvpATWEKYKHLLSPVER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.05|      17|      29|    1228|    1244|      11
---------------------------------------------------------------------------
 1228- 1244 (27.39/18.94)	SDIASQHQLVANLQTLL
 1258- 1274 (26.67/18.22)	SDTQARVRVSTILQSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.67|      10|      27|      78|      87|      13
---------------------------------------------------------------------------
   78-   87 (16.25/ 8.47)	VESGEDVAEE
  103-  112 (17.42/ 9.62)	VSSPTDLNDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.84|      48|     170|     368|     420|      14
---------------------------------------------------------------------------
  368-  420 (74.36/74.34)	DWRKQIdyaIKLTS...SLYTE..GLVEKVeyLDWVVRMLGSAEEKNLPLWAIMVQIY
  539-  591 (69.48/52.20)	DLRLDI...VKLASqclALLPDinGLVSGL..LSWTSSSFRSGDARVYVAAGVLEQLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.87|      28|      29|     668|     695|      15
---------------------------------------------------------------------------
  668-  695 (45.98/31.31)	IPRHLASLRDALLARYGLVAHESAAICS
  700-  727 (44.89/30.37)	ITLELQEGRTKFIDRSGMLQSLSTSARS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13279 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DANLAVATRVPASRPSRALPPSAAARPPAPVRPRPPFPQSGSAVPL
2) ETIIKGGYYDKPPNPSQNETNSARHSIWPN
3) MLTRPLVSSTSRPPLPTRSVTIGQQYPHTQQLRRPAPPSRLSSVRSASGPSQHVDLDEYDSAWRNEVAQKNNASLGHVESGEDVAEEGRPRKKAKIESEAIMVSSPTDLNDEVHDIPPDDAHALLPGAPMPLPPGPQPALRKPTPKKQLNHDPLRKATGLQPPAIAIRL
1337
192
1
1382
221
169










Molecular Recognition Features






MoRF SequenceStartStop




1) LDEYDS
56
61