<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13275

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTHPTSFQARPPSPSSPAGSLKENHRLPISSEHIPQTPTSPPLMSVSEQSHAADFISSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPIMSTTNSFPTPASSVSGHPMNATSEDVDQGRKSFNMGIQDSAENSGAGPAQQPAQQTQHKPTDNDRQSLQTDRTNDFATGQGQHSTDFDAMDVDTEPTRRANTLSLDLDSLQKELTSAFHLCKRSPIVTGPDPSVDLVSLYGLGPIANSVARTDPVTGEKINRLRKSYEGKLKGLGLAGRNKPHKQEVGAPGSLRHMTLWPEEEWQNQKVHGKAIKVADMDSALQNLQSRAMQMEPGPIPNNDFWEDILGHEKAAKNPPSGDTGKKAAAPPSAGRSSTQSHAATPQGQEAERPRPSRGRKRHYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERSASYGVGMFGIGAR
Length457
PositionHead
OrganismPenicillium nalgiovense
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.05
Grand average of hydropathy-0.932
Instability index55.18
Isoelectric point6.60
Molecular weight49135.45
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13275
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.35|      26|      26|      14|      39|       1
---------------------------------------------------------------------------
   14-   38 (43.83/19.72)	.....PP....SPSSPAGSLKENHRL...PISSEHIP
   39-   65 (25.06/ 8.23)	QtptsPPlmsvSEQSHAADF..........ISSHTSP
   67-   95 (25.47/ 8.48)	QatvqPP....NISSPPSSAPMSTQVsqqPIMS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.60|      20|      21|     348|     367|       2
---------------------------------------------------------------------------
  348-  367 (36.75/19.59)	KNPPSGDTGKKAAAP.PSAGR
  371-  391 (32.86/16.63)	QSHAATPQGQEAERPrPSRGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.25|      19|      21|     163|     183|       4
---------------------------------------------------------------------------
  148-  171 (24.63/ 9.67)	QTQHkpTDNDRQslqTDRTNDFAT
  173-  195 (25.62/21.02)	QGQH.sTDFDAMdvdTEPTRRANT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.13|      20|      20|     262|     281|       5
---------------------------------------------------------------------------
  262-  281 (34.65/18.79)	GKLKGLGLAGRNKPHKQEV.G
  284-  304 (34.47/18.66)	GSLRHMTLWPEEEWQNQKVhG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.83|      11|      19|     396|     406|       7
---------------------------------------------------------------------------
  396-  406 (22.39/14.36)	DDNSFAGYGEG
  412-  422 (23.44/15.39)	DDPGFYSNGEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13275 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKGLGLAGRNKPHKQEVGAPGSLRHMTLWPEEEWQNQKVHGKAIKVADMDSALQNLQSRAMQMEPGPIPNNDFWEDILGHEKAAKNPPSGDTGKKAAAPPSAGRSSTQSHAATPQGQEAERPRPSRGRKRHYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERSASYGVGMFG
2) MSDRTHPTSFQARPPSPSSPAGSLKENHRLPISSEHIPQTPTSPPLMSVSEQSHAADFISSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPIMSTTNSFPTPASSVSGHPMNATSEDVDQGRKSFNMGIQDSAENSGAGPAQQPAQQTQHKPTDNDRQSLQTDRTNDFATGQGQHSTDFDAMDVDTEPTRRANTLSLDLD
264
1
453
201










Molecular Recognition Features






MoRF SequenceStartStop




1) FWEDILGH
2) KKKRKKDHVAKVST
336
425
343
438