<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13273

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEGGINMDDLFGESNSLELGMPAASPIKGLAQCLDEMRLLGCCQKIVWSRMGCIASISPDGLRVNVRYLQCRPSDGKWVLGEETSLAPVLEAHNGNQLAHISWNETGSELAVVDCSGRISIYSISIALNSITGLRQASFDSGDDGSQVVGMMWLNTYRHIHAFHQAAKVNGRWAYSPFRRRSTGPFHPANKGALICVTRAGQIKLIYQNPDSKWAELPAELKNTGYSDRLLTHASMTATQDGILLSTYSACQKMCLYRLDIGWNPSQWEPTPGKPPGQFPVPTFRLIHCKVDMPSNILNVNRGPDHSDQSLPFLNSVYSLTRLEIMPGQFDSLAGSTANPWILAVLSKPLHAIHDYPDQQGPPSVIVRWHLESAPQPLHPKFDEVPSKKSNAEAKPKMELRRLEDIYCDKYIVSVDLIEHGAVLAVSHDDSSITCYETRTMTVLNGLGDSNTVTCLAQAGFHYPLETSGLHIAFSPNACVAVTLDADGHVQLRVMEHSFGSTEGLYDETIAALTLAFSRGCGIEVNTDDILMVACGQLSPEARTTFISEVYRALPVNCNFTAEQDKLMSHPYIPRCLSLQAGLGFKGKLQRRNLSSAVPWASLQLRHASVLFAYFFQYNKGGQTESHDPDFSHFLLNEIFDMADEFEGVFNDPEAFTQKLKNSPSLPLLVLLASMSRAFLRFICRGLRGVHAGFASANPASLVGDSRVYYTEICQTLESSPVRIDVYEKFLAGVDSAVKHAYQGAGFGDAERPGPEKELLVNARIPPVLTTAVATLLRQTVPALKSEINRMAIYLGDYSWLGFGNDRRTALYRKQREVDILKKCPLRPPLPLGIDGRVALLKKRRCVRCTEVSGDTNLPRSLLSFKMIAKLSLLRSCLCGGMWVLETDTRDVGVRTTSTNGNGNRVSQA
Length913
PositionTail
OrganismPenicillium nalgiovense
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.148
Instability index45.30
Isoelectric point6.93
Molecular weight100630.05
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13273
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     223.82|      50|      53|     179|     229|       1
---------------------------------------------------------------------------
  136-  175 (43.67/25.76)	........TGlrqaSFDSGDDGSQV........VGMMWL.....NTYRHIHAFHQAAKVNG
  179-  229 (80.73/60.70)	YSPfRRRSTG....PFHPANKGALIC.VTRAGQIKLIYQ.....NPDSKWAELPAELKNTG
  230-  276 (56.54/36.24)	YSD.RLLTHA....SMTATQDGILLS.TYSACQKMCLYRldigwNP.SQWEPTP.......
  278-  316 (42.89/25.15)	......KPPG....QFPVPTFRLIHCkVDMPSNILNVNR.....GPDHSDQSLP.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.22|      16|      26|     805|     820|       2
---------------------------------------------------------------------------
  805-  820 (30.01/16.91)	LGFGNDRRTALYRKQR
  834-  849 (28.20/15.49)	LPLGIDGRVALLKKRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.61|      20|      26|     345|     364|       3
---------------------------------------------------------------------------
  345-  364 (37.75/25.36)	WILAVLSKPLHAIHD.YPDQQ
  373-  393 (34.86/22.84)	WHLESAPQPLHPKFDeVPSKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.22|      19|      24|     564|     585|       5
---------------------------------------------------------------------------
  564-  584 (27.28/26.67)	FTAE.QDKLMSHPyIPRClSLQ
  589-  608 (29.94/13.56)	FKGKlQRRNLSSA.VPWA.SLQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13273 with Med16 domain of Kingdom Fungi
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