<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13269

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMASQDASMEEILWRSPPHVQMMGGFLHSNNILFYFAESPFFDSTSNNASLAIQANYNDAFRHFVETREAFEARLKTMQGLEFMVSYDPLQAAAQTDNRFAHEPSNIWVIRKQNRRKRSGMDDEVTVISTYFVVGDCIYMAPSVASVVGNRILSAVTSLTQLMKSAATLPTFTASHGHTYLPPGVRSKESAGTSQASQSKEATPMPDASFPTTESSQSTSKSSLGGSTTSSAYQDTRSLAESFSLLTRYGDEFMDENPLVGEPGSFILSRTGGETTGSAAKAASKIAAATPTGTPSALPVRSSTPQVRVETPGKASEKSTSPPSSAGDKGKRKKSRIVS
Length338
PositionHead
OrganismPenicillium nalgiovense
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.418
Instability index55.33
Isoelectric point7.83
Molecular weight36315.06
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP13269
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.26|      12|      16|     293|     304|       1
---------------------------------------------------------------------------
  293-  304 (21.30/12.06)	TPSALPVRSSTP
  310-  321 (20.96/11.75)	TPGKASEKSTSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     162.47|      30|      79|     182|     211|       2
---------------------------------------------------------------------------
  141-  170 (32.37/14.71)	PS..VASVVgnrilSAVTSLTQLMKSA.....ATLP..T
  182-  211 (52.71/28.29)	PG..VRSKE.....SAGTSQASQSKEATPMPDASFP..T
  216-  246 (38.88/19.06)	QS..T.SKS.....SLGGSTTSSAYQDTRSLAESFSllT
  262-  291 (38.52/18.82)	PGsfILSR......TGGETTGSAAKAASKIAAAT.P..T
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13269 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GDEFMDENPLVGEPGSFILSRTGGETTGSAAKAASKIAAATPTGTPSALPVRSSTPQVRVETPGKASEKSTSPPSSAGDKGKRKKSRIVS
2) HTYLPPGVRSKESAGTSQASQSKEATPMPDASFPTTESSQSTSKSSLGGSTTSSAYQDTR
249
177
338
236










Molecular Recognition Features






MoRF SequenceStartStop




1) ASKIA
2) LLTRY
3) TSPPSSAGDKGKRKKSRIVS
282
244
319
286
248
338