<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13262

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIDGFSNIHWRIYTEEAGITNNPQESPANGYTILKHLSRLKDLEARLRGLNCLASCPRRLGLWVFSPTPEFESLKPLYVRGSDADSNKIVVGTTTLKVSALGSVSSLDLVKGLSSDNQSQHGTQPAGQPRPHQSQPSSRRQDGYSSSAAIYASFISAVTGSIGLQLIRRHAALPLGSRTLFTAVEQSGYESPHINNDSILSTSCLTTLNIQLTMGGTITVSAQTISQTGITRLCGPREDIAELNDVQPGIDLWLCPNGTIAKLVTANLDSPTAPSLGYPAPGHLSAKRVQWKLDVVQWLRNFGLHVGSIDEEPWVEVEVWEPFFARLAGEAWRQSDDGQSALPLKRMLWPARFCFRRASSSNISFGAQTSLLDEPLDFAERWSTMAGSLKLDHITHTAQNTPTTQDLQPKDQEMPSPPKAESLESIESLSRIAQYPDLQSTNLVYPTPPDGAAAVGLNNPNPSEAFADDSDFGLPHATQHSSRNEPGSDISPVQNSGVGIGTGRYDESDEEDLFGEMNERDFGSKGITDADFSFFDDPDFDGMEGDSRVEDVDEVLETSHPQSELEAEAIVDAEPSPNQPQAILTHVEAHEAHASPVHNEAPQLPEAPLASEEPAHSPTDRAGQTISPPLSPIEVKKILFPGPGADDHQQSTDNRGQGHYHPVAFEKRLGDWDQKYGAAGKFWFSSGGSSDTSNQTSAIPTIGIPHRGRSSANARGSSKERNKTSLSLVQSENGLRSASVSSDSSEDSIEIVSEHVPTPAAMPSMPSLKRKRAPSESDKMSVASQEKSLPGTEASPAYAAENSTFLGNFLANFSDWTLTGYFSAFPPQQLPVLSRREGQLEIAQLLVDQITQSSLKHPLDGKIGLFDLESQSLPLQALDDTPVLGESSKLDFKRYTSLQDEFVANQPQQQPPQHPPPPKDTPRSFISKLSAPHVRVRRGKEYLETLPPAVSFWETFGLEPAHGPKNISAYCIHPQAASKAADVFLRRFGLLYQSCSLGTHTRGDDAVAFEEGLKPWKSETSSYESMMQVLKRTCEQLGSELSQSPATADNHVVYIINPFTHAAALADICSAFWHLSQQLIAGSERRQTRIASELVLQIIPLEFIMSSETMVIPPQMDYLNLALEVYSRCRSNDVDMSPLLCAPPMLLADALPRAISFRLAPERSSPLQDGRGLHIAYSKSLDQRWISVAWSDLSGSIQRTMSYCLRYRQSSGARPVSEIRNEIWTTTKHIMDKFQARWKVQLATTEPMETDEVEAWASLADQHNKVKPGSLELTILAVNTLPDLILELPVPPISMAMLNILSSSTPVSTPNPSASVASPEQSGNAPTPTSAGPATYNATTPTDVSLETDSEAVLTDICDDSWLAILSHRLNSSPHLTEFRPALSSGYLLRRKGATDGDGVFAISVNLIYSPRPPPSHDSVLKDTLTRPRKPKVKVKLKVKGAVIAAATLPYHPSPLSASDSFFLEKNETKSGNCKKKKEDDDDDRDGDVALDHLGWRRSADRGRRDLRW
Length1521
PositionKinase
OrganismPenicillium nalgiovense
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.451
Instability index60.40
Isoelectric point5.30
Molecular weight166096.59
Publications
PubMed=28368369

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13262
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.89|      16|      18|     239|     255|       1
---------------------------------------------------------------------------
  239-  255 (26.24/18.61)	QTGI.TRLCgPREDIAEL
  259-  275 (28.65/15.32)	QPGIdLWLC.PNGTIAKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|    1178.58|     412|     497|     475|     971|       2
---------------------------------------------------------------------------
  475-  971 (579.70/452.90)	SEAfAD..DSDFGLPHATQHSSRNEPGSDISPVQNsgvGIGTGRYDESDEEDLFGEMNE..RDFGSK.....GITDADFSFFDDPdFdgmegdSRVEDVDEVLETS.H...........PQSELEAEAIVDAEP......SPNQ...PQAILTHVeAHEAHASPVHNEAPQlpeAPLASEEPAHSpTDRAGQTISPPLSPiEVKKILfpgpgaddhqqsTDNRGqghYHpVAFEKRLgdwDQKYGAAGkfWFSSGGSSDTS.......NQTS.AIP...........TIGIPHRGRSSANARGSSKERNKTS.....LSLVQSENGLRSASVS..sdssedsiEIVSEhVPTPAAMPSMPSLKRKRAP..SESDKMSVASQEKSlpGTEASPAyaaenstflgnflanfSDWTLTgyFSAFPPQQLPVLSRREGqleIAQLLVDQITQSSLKHPLDGKIGLFDLEsqslPlqALDDTPVLGESSKLDFKRYTSLQDEFVANqPqQQPPQHPPPPKDT...PRSfisklsaPHV....RVRRGKEYLETLP..PA.VSFWETFGLE
  990- 1477 (598.88/306.98)	SKA.ADvfLRRFGLLYQSCSLGTHTRGDDAVAFEE...GLKPWKSETSSYESMMQVLKRtcEQLGSElsqspATADNHVVYIINP.F......THAAALADICSAFwHlsqqliagserRQTRIASELVLQIIPlefimsSETMvipPQMDYLNL.ALEVYSRCRSNDVDM...SPLLCAPPMLL.ADALPRAISFRLAP.ERSSPL............QDGRG...LH.IAYSKSL...DQRWISVA..WSDLSGSIQRTmsyclryRQSSgARPvseirneiwttTKHIMDKFQARWKVQLATTEPMETDeveawASLADQHNKVKPGSLEltilavntlpDLILE.LPVPPISMAMLNILSSSTPvsTPNPSASVASPEQS..GNAPTPT................SAGPAT..YNATTPTDVSLETDSEA...VLTDICDDSWLAILSHRLNSSPHLTEFR....P..ALSSGYLLRRKGATDGDGVFAISVNLIYS.P.RPPPSHDSVLKDTltrPRK.......PKVkvklKVKGAVIAAATLPyhPSpLSASDSFFLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.99|      13|      28|     418|     430|       3
---------------------------------------------------------------------------
  418-  430 (26.63/14.81)	DLQPKDQEMPSPP
  449-  461 (25.36/13.72)	DLQSTNLVYPTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.20|      11|      20|     303|     314|       4
---------------------------------------------------------------------------
  303-  314 (18.10/16.48)	WkLDVVQWLRNF
  326-  336 (23.10/15.48)	W.VEVEVWEPFF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13262 with Med13 domain of Kingdom Fungi
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