<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13251

Description Uncharacterized protein
SequenceMIPHPSAGGQSWGHPMRSLNGGPAQPDHSVDSSQPGSRQPIAIDLTSGGPESQDREPPPKRPRLDVSGSPNLGDNATTANSAESKSTPGSAGARQQVTWRGRPLWSFQAVISEIPGSEGRADGAVSKPASPPPFPVQPWTNAPKDRSRAAGTQVDEDFLPDTKVKTTPYRIQVPSAAPKIKGDRVADFAPWTGHHPEDNLNEQTAKQGYYDRTQVSQNESNTARPALYTQFKHRAGLQMLSNVFTAVLEKRQNHSTVNAPSTFKPPPRVTLTDNKREGWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKWIPVARAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVRDWTSNVQQFVEGVFSSPKSLNWKSKMTYAVGLTARLFFENLLDHDNFLEWFLSSFEAASIATVPIWLLMLGIYWNNIMRYRRRGRQLAEILLKKLRQTTEVQLNTLQPLVDRLTRFITKLAREHTSSLILPNSWDLYKSQVSSCLSLEQKPDRILFQSLAERNARVHRPRQSKQAGQGSPQKRVIQLLDSIHSTFDIASVSSACLDGLSNRAVLVSKLLEWLATPFRHGVCRVYIGVRLLRKWKASGVDIDDHILAFLTQTGSSKKLNVDNIYHAVSELVRSQTFSVGRYLQWLMAKGITSSASSEQKSNLPCDVGLIIQLPVGRLPEHVSNLRGTLLTRMGFPASGEVTTINNVKDLISRRLPAIFDMSMETESSIGVLPTKLSWAIKADVCQWLRRAIAGYTQDATHSSLRTAFSNDKVPLVSAISPNDFYIVRDILETFGDISMLADILRITSTSEDYTVLASIADTTNCHFESLCAIGATSDLYRKIVDAYAGLKRFGIPNLDLMFSLIELGMRIPNEMNTVAILRQDLSRMENRSVIAASSPVSDHIPDSLGDADPLFREKLDHFLLSGNIMDEPTLDSIFNTLTKHLESGNDNAQLSANDTCRYLAQLRSFQPKHFDGILARWVCSHLRAADRCILLRILPPLIGVGCVTIRSFLSLVKRISYSAKAIPNVASLPADLVALLVTRTETDGCLDLVSYRFRLAQQEFLSKDSEQALGIVCSAAAALDASNSTSASQRVKLENSMVHLLLELLVRNPKCSDQKCVQKLLSQHPAALALIQKALDVLLDPNFEDRSSGGETAEVDSKPPVVHDSIVSEVEKLASTTDDFSLPFSQLKLQVLFNADSGHESKDSFVNAMFKTVVADSRSHKNHWVDLVALMNPDAVRQIRERAEKEFFAVPLLEESTETVSSPRNMGTLETAKLYLTIIEELADSIPDSGTPAVGSAIAEKMDALLQKILTMQPKFQNSAEKRPAVPSCKGRSQFERSLAFWFSALLRMVVLHRVSFMQPSPLLKPGSVQEQSRLLISIFCIALSRLPGEILRLFPGADYFPRPGASEDYRPCPGILLQTHALDVAASLIDVFPDEVRLQCARFLKEKCPPFVPLQNDTRFLYLLGPMSDPTSSAALQSASAPSPAASASTPTPASANYPASSTYPQQPAPLQASSSGLAESSNSILNRLRLEHRGRIGAPYPIRSWELLEDAAPLIGVNDTAVNLSFFDARRVRV
Length1582
PositionKinase
OrganismPenicillium steckii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.209
Instability index46.13
Isoelectric point8.91
Molecular weight174477.26
Publications
PubMed=28368369

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13251
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.52|      50|     144|    1365|    1422|       1
---------------------------------------------------------------------------
 1365- 1422 (81.35/51.67)	QPSPLLKPGS.VQEQSRlliSIfciaLSRLPGEiLRLFPGADYFPRPGA.SEDYRPCPGI
 1514- 1565 (82.17/36.41)	QPAPLQASSSgLAESSN...SI....LNRLRLE.HRGRIGAPYPIRSWElLEDAAPLIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     192.81|      52|     144|      30|      89|       2
---------------------------------------------------------------------------
   30-   88 (82.72/50.07)	VDSSQPGSrqpiaiDLTSGGPESQDREPPPkRPRLDVSGSPNLGDNATTANS.........AESKSTP
  110-  168 (82.48/33.69)	VISEIPGS......EGRADGAVSKPASPPP.FPVQPWTNAPK..DRSRAAGTqvdedflpdTKVKTTP
 1141- 1165 (27.61/ 6.52)	..................................LDVLLDPNFEDRSSGGET.........AEVDSKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.32|      43|     146|     589|     631|       3
---------------------------------------------------------------------------
  344-  385 (58.28/38.19)	LAVGLEAKWVR...DWTSNVQQFVEGVFSSpKSLNwKSKMTYAVG
  386-  406 (23.58/10.79)	LTARLFFE...NLLDHDNFLEWFL.....................
  589-  631 (71.47/48.61)	IGVRLLRKWKASGVDIDDHILAFLTQTGSS.KKLN.VDNIYHAVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.28|      11|      14|     795|     805|       5
---------------------------------------------------------------------------
  795-  805 (19.73/12.77)	TFGDISMLADI
  811-  821 (18.55/11.57)	TSEDYTVLASI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.69|      20|     223|     764|     783|       9
---------------------------------------------------------------------------
  764-  783 (33.53/18.91)	SSL....RTAFSNDKVPLVSAISP
  986- 1002 (29.64/15.84)	SHL....RAA...DRCILLRILPP
 1013- 1035 (25.51/12.58)	SFLslvkRISYSAKAIPNVASL.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.16|      32|     198|    1227|    1258|      10
---------------------------------------------------------------------------
 1227- 1258 (58.97/36.98)	KNHWVDLVA.LMN..PDAVR.Q.IRERAEKEFFAVPL
 1425- 1461 (41.20/23.59)	QTHALDVAAsLIDvfPDEVRlQcARFLKEKCPPFVPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13251 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LWSFQAVISEIPGSEGRADGAVSKPASPPPFPVQPWTNAPKDRSRAAGTQVDEDFLPDTKVKTTPYRIQVPSAAPKIKGDRVADFAPWTGHHPEDNLNEQTAKQGYYDRTQVSQNESNTARPALY
2) MIPHPSAGGQSWGHPMRSLNGGPAQPDHSVDSSQPGSRQPIAIDLTSGGPESQDREPPPKRPRLDVSGSPNLGDNATTANSAESKSTPGSAGARQQVTWRGR
3) SAALQSASAPSPAASASTPTPASANYPASSTYPQQPAPLQASSSG
104
1
1480
228
102
1524










Molecular Recognition Features






MoRF SequenceStartStop




1) PIAID
2) PLWSFQAVI
40
103
44
111