<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13249

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGSATTNIHIIDGFSTIYWRIYTEEQGISNHPQDGPANGYTILKHLGRLKDLEARLRGLNCLASCPRRLGLWVFSATPNFESLASLYIKEGDTGTTKILVDTTTLKVSASGSVGSQELIKSLSAESQNTTGTQPSAQQRPQQPQSNPRRPDGYSSSAAIYASFVSAVTGAISLHLIRNRGALPLGSRTLFTAVEKTGYESPRIDHESALSQSCLTTLNVQLNASGALTISPQTIAQLGITRLCSPRDDIDDLLRVQPGTDIWLCPNGAVARLVTANIEAPAVPSPEYPSSVNSFSKQQQWKLDVVQWLVNFGLHIDSIDEEPWVEVEVWEPFFARLAGETWRQSEDTQSSLPLKRMLWPARFCFKRTGPMVQSSCLPPTLDDPLDFAEQWFSETSSLKINQDLPNIPLTEEPQMKDHDVASPQLDNVENLESLSRMAQYPDLQSTNLVYPTPPDGAVNVGINNTNVSDMSPDDPDFNLSPTAEQDVKNPANVQFSPEIQVGTGRYDASDDEDLFGDMDDKDFGSKEITDADFSFFDSPTLEPVMEDAPSHEISAETPLAAPAKQEAVKEESPGIKDEGGPVDGSVEAHHVIGPLEKKEHISTKEDPQKSPVDESMALDELPPSPQEPKSQTISPPLSPVEIKKILFPGSEVQEPNQKDDSRIQQGHYHPIAFKNKIGDWDQKYGATGKFWFSTGGASDTLTQDSNSIPTIGMPHRGRGNAPTKSTGQSAALPALDNHSRSSSVSSSNSSYLSDDAPPENASLPLPMTISSLKRKRVPSESDIQSTASPAKSSNAPESGVVSKGDNTTFLGNFLANFSDWTFIGYFSATQIQQLPVLLKREDQVPIAQLLVDQIIQSSFEHHLAPCVDLFGSNSDNMLMQTCLEGGNFLGDMSRLDLRGYTTFQEDSAIAQPPSRDPSKNPICKSFAPHLRVRRGKEFLEALPPSVSFWETFGLEPACGPKDISAYCIHPVVALEAANVFLDRFGLLYQSCNFGNHTRGNQSTAFANGLGSWGSEDSSYSSMMQSLNKLCEKLGIELAQTSPTTDNCVVYIINPFPHAAALADICAAFWRLFQQLAADADQQQNRQINDVVLQIIPMDFILSEDSMVVPTQSEYLNLALEVYSRCRPKDVDVGPFTCASAISLANPTPKTIAFRLVPEKGSPLQDGRCLHLAISKSLDQRWVSAAWSDGDGGLQMSMSYCLKYRGRSLSKPIGEVRNEIWATTKHIIDNHQARWKLILVNTEPMDTDDMEGWANLADQLNKLRPGALELAIVTVSTVPDLLLETPVSPMTNNVLNPHLSSTPVSTPNPSMSIASPEQTGNAPTPGALYNAPTPTDASIEPDSDVVLADMRDESWTVILSHRLNNSHHVTELRPALVSGYLLRRKGATDSEGAFAMTVNLVHSPRSASSHENMLRDILGMYRDLATLSRARGIRSVQNNTLPWHIATALRAQELLSYVL
Length1460
PositionKinase
OrganismPenicillium steckii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.375
Instability index52.94
Isoelectric point4.91
Molecular weight159705.05
Publications
PubMed=28368369

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13249
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     487.95|     155|     645|     282|     482|       1
---------------------------------------------------------------------------
  312-  481 (233.42/183.34)	VNFGLHIDSIDEEPWVEVEVWepFFARLAGETWRQseDTqSSLPLKRMlwPAR....FCFKRTGpmvQSSCLpPTLDDPLDFAEqwFSETSSLKINQDLP....NIPLTEE.PQMKDHDVasPQLDNVENLESLSRMAQYPDLQSTNLVYPTPPDGAVNVGINNTNVSDMSPDDPDFNL
  486-  537 (39.01/34.48)	............................................................................................................................EQDVKN...PANVQFSPEIQVGTGRYDASDDEDLFGDMDDKDFGSKEITDADFSF
  673-  821 (215.53/98.30)	IAFKNKIGDWDQKYGATGKFW..FSTGGASDTLTQ..DS.NSIPTIGM..PHRgrgnAPTKSTG...QSAAL.PALDNHSRSSS..VSSSNSSYLSDDAPpenaSLPLPMTiSSLKRKRV..PSESDIQSTASPAKSSNAPE...SGVV..SKGDNTTFLGNFLANFSD..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.82|      20|     645|     620|     658|       2
---------------------------------------------------------------------------
  596-  615 (35.31/20.82)	PLEKKEHISTKEDPQKSPVD
  624-  643 (37.52/39.92)	PPSPQEPKSQTISPPLSPVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.25|      18|      30|     943|     960|       3
---------------------------------------------------------------------------
  912-  925 (26.41/12.27)	AQPPS....RDPS.KNPIC
  943-  960 (36.05/19.46)	ALPPSVSFWETFG.LEPAC
  975-  993 (25.80/11.82)	ALEAANVFLDRFGlLYQSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.56|      42|    1213|       7|      53|       4
---------------------------------------------------------------------------
    7-   53 (63.45/55.30)	ATTNiHIIDGFSTiYWR.IYTEEQGISNHPQDGPANgytILKHLGRLK
 1223- 1265 (72.11/44.41)	ATTK.HIIDNHQA.RWKlILVNTEPMDTDDMEGWAN...LADQLNKLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.27|      20|     124|    1142|    1165|       7
---------------------------------------------------------------------------
 1142- 1163 (27.88/25.11)	AISLAnpTPKTIAFRLVPEKGS
 1170- 1189 (36.39/17.35)	CLHLA..ISKSLDQRWVSAAWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.24|      42|      42|     224|     265|       8
---------------------------------------------------------------------------
  183-  218 (46.65/27.96)	.......GALPLGSRTLfTAVEKTGYESPRIDHESALSQSCLT
  221-  262 (69.32/45.73)	NVQLNASGALTISPQTI.AQLGITRLCSPRDDIDDLLRVQPGT
  263-  288 (34.27/18.26)	DIWLCPNGA..VARLVT.ANIEAPAVPSP..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.36|      21|      27|    1276|    1298|       9
---------------------------------------------------------------------------
 1276- 1298 (33.14/18.13)	VST.VPDLLLETPvsPMTNNVLNP
 1305- 1326 (34.21/14.05)	VSTpNPSMSIASP..EQTGNAPTP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13249 with Med13 domain of Kingdom Fungi
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