<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13245
Description |
Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSERERDPSTTFRVGPPSPSSPAAGLLKENRQLPISSDHIPQTPTSPPLMSVSDSNHVSNFTPSQTSPNQATTQLPSTSSPPSSTPMSTQVSQQPTLSTTNSFPTPASSVSGQHANATSIDDTDHQSFNSTSQGPTRSVKISEQQTSEHRRTDHERQQSATGTGAGVRDFAKEQTDGDAMDVDKEPVARSDVQNLGLDSLQNHFTSAFHLCKSLPTVTGPDPSFDLISLYGLGPVAQSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPVKQEPGAPGSLRHLTMWPEEEWQNQKVMGKQIKVSDIDTALQGIQSRAMQLEPGMVPNNDFWEDVLGHEKPAKAQGSGDTGKKAAAPTPGNHSARPSNMSTAAMQESDRNRPSRGRKRHYDDNSFVGYGEGYADDDDDDNTGYHSNGEGTGKKKRKKDHVSKVSTPLSERGGSYGVGMFGIGAR |
Length | 456 |
Position | Head |
Organism | Penicillium steckii |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.940 |
Instability index | 48.96 |
Isoelectric point | 6.54 |
Molecular weight | 49058.20 |
Publications | PubMed=28368369
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP13245
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 126.23| 25| 27| 102| 126| 1
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60- 74 (24.06/ 8.74) NF.......TPSQ.........TSPNQATTQ
79- 100 (27.93/11.35) SS......PPSSTPMSTQVSQQPTLSTT...
102- 126 (43.61/21.94) SF......PTPASSVSGQHANATSIDDTDHQ
127- 155 (30.63/13.17) SFnstsqgPTRSVKISEQQTSEHR..RTDHE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 184.04| 57| 165| 171| 233| 2
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171- 233 (86.29/56.72) AKEQTDGdamDVDKEPVARSDVQNLGLDSlqNHFTSAFHLC.KSLPTvTGPDPSFDLISLYGLG
344- 401 (97.76/49.02) AKAQGSG...DTGKKAAAPTPGNHSARPS..NMSTAAMQESdRNRPS.RGRKRHYDDNSFVGYG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.32| 18| 37| 284| 303| 4
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284- 303 (31.37/29.48) RHLTMWP.....EEEWQNqkVMGKQ
319- 341 (27.95/18.75) RAMQLEPgmvpnNDFWED..VLGHE
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