<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13241

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMLPNEANSDRWRTFLHRCLSQRVDVDEFKGLSKLMLNRSPVKEDELLDLLLGARATSSVSWDPLLPVYVDGLCKVGQVKPSAALTSLLKHSSIRGTTESKSKTSTLMTDIKVIQDVMMAVSTGAIPRTIAEAADLFFAAAGWIEAVVSWHNENLDIMQQASGLMSNPDAVSLFESVGILLAALFNTTKGIDALTSTWIDRAHQGLKVKLGQSITSYLPICVDVSLPLRHRLDALQKEFNLYGQQPSKNLENSEIEGLNVNSLHFETSVIDGPIINTRAGLYVYLNSMLVGRPLVDDSILINFLTNRYEDHQEILISEMITAAFDVLSNGVNRNESGRTMFLFRSFLVNKLPALFSAMTTASMVPIPIEMCITQALSRLDPNAFPSFSQMFSMQGSSILSDARQEFLFACANHRLIPESSIERLLGENPMQTLPVGGPYQKDDLVPQITTNLERADQLIGEIESMEGNAGAIVRAVTEVMYGLCHQKETVTLKGICNSLSRRPEALDVILLFRTAKQVLQPLCALLDSWRWDEEQGENQLVYDEFGSILLLVLAFKYRYELSPSDIGISSNSSFLVKLFDRGARSQKLSDLSEKQNKDLGSWITALFIAEGINEETMSSCSPQEFYLLVATLFDQSLGACESGKLDFDTVKGGFEYLLEPFLLPALVVGLGWLGNHLWESETDPAIPLKTLLSLVKPSSISGEAQAIHKTVLNITARPLEEQLKDVRTRHQSRTDIKPILDALDPYLSFRRVGSSHRSELDNWAAQPVGGLPGSIRNTLQALVLWSTNSEMAMQPQSYTHRQMLAGIRILGSARVLAALLDELKHQAETGHVDIALDIAATIVCAPMAESFAVDQNSCQPVDSTKEALPRCSILTLRDALALQHDNVPKISEKDPVRAEIIVRLWRRVSVLAAPPSQVSNIDVSNIIHNMHLGGVDGQDRMDLEPSAGDVGGDGVGEDNSDNINDMLDKAAAAAAAGMDGGVGVGQDLGLDVGDTGMDTTGMDAIDDVLNAADMAVGNPEFLDLDMEGMF
Length1029
PositionTail
OrganismPenicillium steckii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.029
Instability index42.18
Isoelectric point4.79
Molecular weight112587.18
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13241
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.50|      25|      40|     940|     972|       1
---------------------------------------------------------------------------
  948-  972 (45.55/36.88)	DVGGDGVGEDNSDNINDMLDKAAAA
  990- 1014 (43.95/19.12)	DVGDTGMDTTGMDAIDDVLNAADMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     291.92|      93|     144|     217|     318|       2
---------------------------------------------------------------------------
  217-  318 (140.32/100.33)	LPI....CVDVSLplrHRLD..ALQKEFNLYGQQPSKNLENSEIEGLNVNSLHfetSVIDGPIINTRAGlYVYLNSMLVGRPLVDDSILINFLTNRYEDHQeiLISEM
  363-  461 (151.60/85.27)	VPIpiemCITQAL...SRLDpnAFPSFSQMFSMQGSSILSDARQEFLFACANH...RLIPESSIERLLG.ENPMQTLPVGGPYQKDDLVPQITTNLERADQ..LIGEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     472.66|     150|     234|     463|     621|       3
---------------------------------------------------------------------------
  463-  621 (242.96/147.26)	SMEGNAGAIVRAVTEVM.YGLCHQ.KETVTLKGICNSLSRRPEALDVILLFRtakQVLQPLCALLDSWRWDEEQGENQLVYDEFGSILLLV....LAFK...YRYELSPSDIGISSNSSFLVKLFDrgarsqKLSDLSEKQNKDLGSWITALFIAEGINEE...TMSSCSP
  698-  859 (229.70/124.17)	SISGEAQAIHKTVLNITaRPLEEQlKDVRTRHQSRTDIKPILDALDPYLSFR...RVGSSHRSELDNWAAQPVGGLPGSIRNTLQALVLWStnseMAMQpqsYTHRQMLAGIRILGSARVLAALLD......ELKHQAETGHVDIALDIAATIVCAPMAESfavDQNSCQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.33|      53|     618|      15|      91|       4
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   15-   91 (75.76/75.78)	LHRCLSQRVDVDEFKGlsklmlnrspvKEDELLDLLLgaratssvswdplLPVYVDGLCKVG......QVKPSAALT...SLLKHS
  636-  697 (84.57/43.87)	LGACESGKLDFDTVKG...........GFEYLLEPFL.............LPALVVGLGWLGnhlwesETDPAIPLKtllSLVKPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13241 with Med5 domain of Kingdom Fungi
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