<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13239

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDNANIEGSVRRPAPNEAVNGASGTFGNHEKSGQHSAATNGPVLVNGAGRGIDSLGQQSKIAIRNADSKPYELPHITQGFFPFGTLVNRAVQQCWNDLSELVTELAAIQVPHEPSSASVMNGKSPGNQSSENVHKKLRILDFAHAKRAEFIKLLVLSQWSRQASEVSRLIDIQGFIRTRHQAYASAVQYVGEMKRDLVRAQVANPDLKTALEILYKGRVASLPDFGYKPPKALTARSTLKKLRKINRIISVRLAVYDEVPHSLRNYRIHDGRVTFTVPGEFELDLAVAEETKTSQFFFVDIRFLFSPSSPIPKGRIFNELDAKVNDILHNDGLAGCFDFLHGLVLTNKISTLHRQAVDLARGLWSDSLRIELLHRILVVQYWPSRAGPKSWLEIGVQRGSRKNMNQGNDRVSSVAVRWVRDGQKVNSDHINFDPKLLSLESILRSVIALHTSHLLAAAFTTLKKSQLFATHKLSLRAQLSKTEPGDCHLDVQLTASRSLRVSVEPLSGAIILSGSSSALEQFNVERQPKSTIDEILSRVSRLRSHVAVYQIESGIKPLGLESIHQRGLGVDVRRLFPTNTLRYSFFTHQQWDRRYVVAATSSMDGDKWWLVPVRATETSRALAPPYGTKDSSLLAHAISDELMPSQKLDYSACSELVHSLSGILAIYANARSLADLPGSSFYPALKDLRLGPNLEVPELVFSYKPNSIPAAFRLALPRFQKGSYLQDSIRLCFKGIDRESHSAILVAYGSFKYSIKSLVVLISSADPSLIVQEKGAGFALQILAPAGQSVLVSLFERLQRLDCIIYILQSLIQKKMHPRSLSLSEIVFSYGQGNGLSARIGIDVSRPSPTDLIEIATSLSNQNSFFRLRLRIDFDSPSPHRRIQESLTVALNERFSESGVDYALSSIAETSPLLYSLDRITKPSQQTSSVVHIIVRTPTVFQLNYFRKAQFRLSIRPRQGRTVWLLEDFNPKTSYVQNQGQDQDPAQAYTVVREQVYNSKGTGWQGLGDGALSSIEEVGNLLNKLHECVSDCPLEAIKQEQEQSSKPQPNTVTVKQQQQQPPPPPPTAVPKVETSPQKPVVGNNADVITID
Length1096
PositionTail
OrganismPenicillium steckii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.241
Instability index49.15
Isoelectric point9.41
Molecular weight121540.07
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13239
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.34|      51|     269|     500|     584|       1
---------------------------------------------------------------------------
  393-  462 (70.34/23.38)	PKSWLEIGVQRGSRKNmnqgndrvSSVAVRWVRDGqkvnsdhinfdPKLLSLESILRSVIALHTSHLLAA
  533-  583 (87.00/84.08)	PKSTIDEILSRVSRLR........SHVAVYQIESG...........IKPLGLESIHQRGLGVDVRRLFPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.95|      30|     107|     893|     922|       4
---------------------------------------------------------------------------
  893-  922 (50.74/39.67)	TVALNERFSESGV......DYALSSIAETSPLLYSL
  995- 1030 (44.21/33.43)	TVVREQVYNSKGTgwqglgDGALSSIEEVGNLLNKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.41|      31|     394|     465|     497|       5
---------------------------------------------------------------------------
  465-  497 (47.04/39.59)	TTLKKSQLFatHKLSLRAQLSKTEPGDCHLDVQ
  841-  859 (22.16/ 9.98)	.............LSARIGIDVSRPSPTDL.IE
  862-  889 (49.21/34.47)	TSLSNQNSF..FRLRLRIDFDSPSP...HRRIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.17|      44|     452|     216|     259|      12
---------------------------------------------------------------------------
  216-  259 (74.76/37.85)	LEILYKGR.VASLPDFGYKPP.KALTARSTLK..KL...RKINRI.ISVRLA
  669-  720 (53.41/25.32)	LAIYANARsLADLPGSSFYPAlKDLRLGPNLEvpELvfsYKPNSIpAAFRLA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13239 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AIKQEQEQSSKPQPNTVTVKQQQQQPPPPPPTAVPKVETSPQKPVVGNNADVIT
2) DNANIEGSVRRPAPNEAVNGASGTFGNHEKSGQHSAATNGPVLVNGAG
1041
7
1094
54










Molecular Recognition Features






MoRF SequenceStartStop




NANANA