<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13236

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEGGINVDDLFGESNSLGLGLPPPVPTKGLAQCLDEMRLLGCRQKITWSRLGCVAYITPDATRVSVRHLQCRPSDGKWVLSEESPLTPVTEAHGGNPLVHLSCNETGSELAVVDCLGRVSIYSISMALNSITGLRQASFDSSDDSNQIVGMMWLNTTRSVHAFHQATKVSGRWTYSPFRRRPIGPFHPANKGALICVTRAGQIRLIYQNPDSKWAELPAELKNTGYSDRLLTHASLVATQAGILVATYSVCQKLCLYRVQVGWNPQQWDPSQAKHPNQFPIPSFRILQCKVDMPSPILNINRGPDEQINSSLPFQNTVYSLTKLEIMPGQVDGQQGSTSSPWILAVYSKPLHATPEYPDQQGPPSVIVRWHLENAPQEIHPKFDEVPSKKSNTQVKQKMELRRLDDIHCHRYVISVDMVEHGTALAITHDDSSVSFYDPRGMSLFNGMDDGSTVTCLTQAGYQYPMETPGTAISFSPNSCAAVTLDSDGQTHLRLMEHSFGSAGDLYDESKFSSAIAALTLAFSRGCGAEVNTDDILMVAIRQLSAEAQATLITEVFRALPVNCNFTVDQEKLMTHPYIPKCLSLQSSLGYRGRLKRRTLASSVPWAIVQLRHASVLFAFFFQHTKGSPNEAHDPEILRMILGNTRWTLDFSHFVLSEAFDLADEFESVFNDQEAFTQKLKSTTSIPLLTLLSSMSRAFLRFICRGLRGVHAGFAATNPATLSSESRIYYTEICKLLETSPVRIDVYEKFLAGVDSAVKHAYQGAGFGDAERPGPEKELLVNARIPPVLVSAVATLLRQTIPSLKSEINRKDILLNDYSWLGFGTDARTAAYRRQRDVDILKKAPLRPALAVGKDGRVLQPQKRRRCVRCCEVSGDTALPRSLPYFKMLVKLNLLRACPCGGMWMLETGTGGVSGGGGGGGGAGSGSGSGSGSGAASGNSLQSSGRTPAPV
Length955
PositionTail
OrganismPenicillium steckii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.191
Instability index45.74
Isoelectric point8.32
Molecular weight104406.93
Publications
PubMed=28368369

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13236
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     254.72|      83|     104|     515|     600|       1
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  515-  600 (127.10/86.77)	KFSSAIAALTLAFSRGCGAEVNTDDIL..MVAIRQLSAEAQATLITEVFR.ALPVNCNFTvDQE....KLMTHPYIPkCLSLQSSLGyRGRLK
  616-  705 (127.62/75.01)	RHASVLFAFFFQHTKGSPNEAHDPEILrmILGNTRWTLDFSHFVLSEAFDlADEFESVFN.DQEaftqKLKSTTSIP.LLTLLSSMS.RAFLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.73|      24|      25|     322|     346|       2
---------------------------------------------------------------------------
  302-  318 (22.48/ 9.63)	......LNINRGP..DEQINSS..LPF
  322-  346 (41.71/30.06)	VYSlTKLEIMPGQVDGQQGSTS..SPW
  350-  374 (40.55/24.39)	VYS.KPLHATPEYPD.QQGPPSviVRW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.46|      18|      20|     154|     172|       3
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  154-  172 (30.41/22.32)	GmMWLNTT...RSVHAFHQATK
  175-  195 (33.05/19.10)	G.RWTYSPfrrRPIGPFHPANK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.96|      13|      16|     425|     437|       4
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  425-  437 (23.14/12.29)	HGTALAITHDDSS
  444-  456 (24.82/13.64)	RGMSLFNGMDDGS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13236 with Med16 domain of Kingdom Fungi
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