Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSNLTQEQIKVLEQSRQRLVQLTRSLGSLIASLNQSDPLPPWTSLQSQASIISNNLISVSEQLSDQRDLLSNLVAYPGPEYPGRTQANTLEQLLRTKLDPRVEDWVARGRAAGTEPAVGPSSNFASDPDAAHKPLSEAELAHLWEWAPLEANQEARRRNWGGNYTLEEREAGIENVVTGLRRQLEDDDGSEEESEGEEGDKEEMDVIGVHRKPGAAELEFKIASHHPHPVQPFVPLDLILRHMTTGRMP |
Length | 249 |
Position | Head |
Organism | Penicillium vulpinum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.677 |
Instability index | 54.43 |
Isoelectric point | 4.85 |
Molecular weight | 27716.43 |
Publications | PubMed=28368369 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP13233 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 34.63| 12| 16| 45| 57| 1 --------------------------------------------------------------------------- 45- 57 (14.95/16.07) LQSQASIISnNLI 63- 74 (19.68/14.35) LSDQRDLLS.NLV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 41.50| 11| 14| 203| 213| 2 --------------------------------------------------------------------------- 203- 213 (19.92/12.08) EMDVIGVHRKP 219- 229 (21.58/13.56) EFKIASHHPHP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) LDLILRHMTTGRM 2) LEFKIA | 236 218 | 248 223 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab